By DONALD G. McNEIL Jr. WATERLOO, Sierra Leone — Although the rainy season was coming on fast, Zainabu Sesay was in no shape to help her husband. Ditches had to be dug to protect their cassava and peanuts, and their mud hut’s palm roof was sliding off. But Mrs. Sesay was sick. She had breast cancer in a form that Western doctors rarely see anymore — the tumor had burst through her skin, looking like a putrid head of cauliflower weeping small amounts of blood at its edges. “It bone! It booonnnne lie de fi-yuh!” she said of the pain — it burns like fire — in Krio, the blended language spoken in this country where British colonizers resettled freed slaves. No one had directly told her yet, but there was no hope — the cancer was also in her lymph glands and ribs. Like millions of others in the world’s poorest countries, she is destined to die in pain. She cannot get the drug she needs — one that is cheap, effective, perfectly legal for medical uses under treaties signed by virtually every country, made in large quantities, and has been around since Hippocrates praised its source, the opium poppy. She cannot get morphine. Copyright 2007 The New York Times Company

Keyword: Pain & Touch
Link ID: 10708 - Posted: 06.24.2010

By MARILYNN MARCHIONE NASHVILLE, Tenn. -- The war in Iraq is not over, but one legacy is already here in this city and others across America: an epidemic of brain-damaged soldiers. Thousands of troops have been diagnosed with traumatic brain injury, or TBI. These blast-caused head injuries are so different from the ones doctors are used to seeing from falls and car crashes that treating them is as much faith as it is science. "I've been in the field for 20-plus years dealing with TBI. I have a very experienced staff. And they're saying to me, 'We're seeing things we've never seen before,'" said Sandy Schneider, director of Vanderbilt University's brain injury rehabilitation program. Doctors also are realizing that symptoms overlap with post-traumatic stress disorder, and that both must be treated. Odd as it may seem, brain injury can protect against PTSD by blurring awareness of what happened. But as memory improves, emotional problems can emerge: One of the first "graduates" of Vanderbilt's program committed suicide three weeks later. "Of all the ones here, he would not have been the one we would have thought," Schneider said. "They called him the Michelangelo of Fort Campbell" _ a guy who planned to go to art school. © 2007 The Associated Press

Keyword: Stress
Link ID: 10707 - Posted: 06.24.2010

By NICHOLAS WADE Could people one day evolve to eat rich food while remaining perfectly slim and svelte? This may not be so wild a fantasy. It is becoming clear that the human genome does respond to changes in diet, even though it takes many generations to do so. Researchers studying the enzyme that converts starch to simple sugars like glucose have found that people living in countries with a high-starch diet produce considerably more of the enzyme than people who eat a low-starch diet. The reason is an evolutionary one. People in high-starch countries have many extra copies of the amylase gene which makes the starch-converting enzyme, a group led by George H. Perry of Arizona State University and Nathaniel J. Dominy of the University of California, Santa Cruz, reported yesterday in the journal Nature Genetics. The production of the extra copies seems to have been favored by natural selection, according to a genetic test, the authors say. If so, the selective pressure could have occurred when people first started to grow cereals like wheat and barley at the beginning of the Neolithic revolution some 10,000 years ago, or even much earlier. Copyright 2007 The New York Times Company

Keyword: Genes & Behavior; Evolution
Link ID: 10706 - Posted: 09.10.2007

Roxanne Khamsi A brain scan might one day predict your voting patterns. That is the implication of a study that found different brain activity among liberals and conservatives asked to carry out a simple button-pushing test. The study implies that our political diversity may be the result of neurological differences. Researchers have long known that conservatives and liberals score differently in psychological profiling tests. Now they are beginning to gather evidence about why this might be. David Amodio of New York University, US, and his colleagues recruited 43 subjects for their test. They asked the participants to rate their political persuasion on a scale of -5 to 5, with the lowest number representing the most liberal extreme and the highest number representing the most conservative score. The participants then had to sit before a computer screen and press one of two buttons depending on whether they saw an "M" or a "W". They had half a second to make each response, so there was a great deal of pressure to react quickly. Out of the 500 trials that each subject completed, he or she was presented with the same letter 80% of the time. This meant that the participants felt compelled to press the same button repeatedly. © Copyright Reed Business Information Ltd.

Keyword: Emotions
Link ID: 10705 - Posted: 06.24.2010

Ewen Callaway Spit might have helped human evolution by enabling our ancestors to harvest more energy from starch than their primate cousins. Compared with chimpanzees, humans boast many more copies of the gene that makes salivary amylase — a saliva enzyme that breaks down starch into digestible sugars. And carbohydrate-loving societies carry more copies of the gene than those that follow low-carbohydrate diets, claims a new study in Nature Genetics1. This strongly implies that people have adapted to their local environment. "High starch foods and a high starch diet have been an important evolutionary force for humans," says George Perry, an anthropologist at Arizona State University in Tempe, who led the new analysis. The change could possibly have supported the growth in hominin brains that occurred some two million years ago, says Nate Dominy, an anthropologist at the University of California in Santa Cruz involved in the study. "Our diet must have had some shift to feed that brain," says Dominy, who thinks root vegetables like African tubers allowed large-brained humans to flourish. Starch, which helps to make a baked potato mushy, is an important source of food for modern humans. But without amylase in the saliva, man can make little use of such complex carbohydrates - enzymes elsewhere in the body are not as good at breaking the compounds down. ©2007 Nature Publishing Group

Keyword: Genes & Behavior; Evolution
Link ID: 10704 - Posted: 06.24.2010

By ARTHUR MAX VENLO, Netherlands -- Do you find your fingers drifting into your mouth when you're nervous, anxious or just bored? Are your nails chewed to splinters or your cuticles gnawed to bleeding pulp? Nail biting is more than a bad habit. Doctors say it is one of the most common symptoms of stress or of an obsessive-compulsive disorder, especially for teenagers or younger children, and can lead to disfigurement and serious infection. Alain-Raymond van Abbe, a former health industry and cosmetics promoter, estimates the world's pathological nail biters number 600 million or more. He saw that onychophagy was so widespread that he has opened a business devoted to a cure. A car carrying an advertisement of the nail biting clinic with a slogan saying: "Stop nail biting now!" drives in front of the nail biting clinic, O-Centrum, in Venlo, Netherlands, Monday, Aug. 20, 2007. Alain-Raymond van Abbe, a former health industry and cosmetics promoter, estimates the world's pathological nail biters number 600 million or more. He saw that onychophagy was so widespread that he has opened a clinic devoted to curing nail biters. "In four weeks nail biting can be over, and over forever," he says. (AP Photo/Ermindo Armino) (Ermindo Armino - Associated Press) Studies show around 45 percent of adolescents nibble their nails. That drops to about 20 percent as young adults learn to cope with their anxieties or become too embarrassed by their self-inflicted deformity. © 2007 The Associated Press

Keyword: Stress; OCD - Obsessive Compulsive Disorder
Link ID: 10703 - Posted: 06.24.2010

Matthew Swulinski was steps from the World Trade Center on September 11, 2001 when he managed to take a series of haunting photographs. "It was too late for me to run away, it was too late for me to hide anywhere," he recalls. "I was actually standing and waiting for this to be over." His photos are a physical record of what he experienced that day, but neuroscientist Elizabeth Phelps at New York University and graduate student Tali Sharot, now a post doctoral fellow at University College London, studied people like Swulinski to learn about a different kind of snapshot: the so-called "flashbulb memory," a vivid moment in time that we seem to remember as if it were a photograph. Roger Brown and James Kulik coined the term “flashbulb memory” in 1977 to describe people’s uncanny ability to recount where they were and what they were doing on November 22, 1963, the moment they heard that John F. Kennedy had been assassinated. Swulinksi describes his September 11, 2001 experience with extra intensity because he was at Ground Zero. “I remember parts of the building falling around me everywhere. And I was just basically hit by glass– it’s kind of a miracle. And later – that’s the moment I realized that I’m in danger– and after the second plane, I left the area. I was still involved because of the falling towers and the cloud that appeared after that. The clouds actually covered me.” © ScienCentral, 2000-2007

Keyword: Learning & Memory; Stress
Link ID: 10702 - Posted: 06.24.2010

By Nikhil Swaminathan In late 2004 the Internet Movie Database reported that Dustin Hoffman suddenly had the urge to breast-feed. Had the then-67-year-old Hoffman—who brought mainstream culture face to face with autism in Rain Man and went mano a mano with an Ebola-like filovirus in Outbreak—never quite broken character from his 1982 film Tootsie? Nope. He was just really keen to help out with his first grandchild. Interestingly, he could have possibly lent a helping, er, breast, if he had held the suckling newborn to his nipples for a couple weeksalthough he could also have tried starving himself or taking a medication that would affect his brain's pituitary gland. There have been countless literary descriptions of men miraculously breast-feeding, from The Talmud to Tolstoy, where, in Anna Karenina, there is a short anecdote of a baby suckling an Englishman for sustenance while on board a ship. The little anthropological evidence documented suggests it is possible. In the 1896 compendium Anomalies and Curiosities of Medicine, George Gould and Walter Pyle catalogue several instances of male nursing being observed. Among them was a South American man, observed by Prussian naturalist Alexander von Humboldt, who subbed as wet nurse after his wife fell ill as well as male missionaries in Brazil that were the sole milk supply for their children because their wives had shriveled breasts. More recently, Agence France-Presse reported a short piece in 2002 on a 38-year-old man in Sri Lanka who nursed his two daughters through their infancy after his wife died during the birth of her second child. © 1996-2007 Scientific American, Inc

Keyword: Hormones & Behavior
Link ID: 10701 - Posted: 06.24.2010

Matt Kaplan It may seem strange, but many monkeys wash their hands and feet with urine. Researchers now think they know why. Since this odd behaviour was first observed, explanatory theories have varied wildly from suggesting that it helps monkeys improve their grip when climbing to saying it is a method of cleaning. One widely supported theory argues that monkeys use urine washing to cool themselves down when temperatures get too high. But new research hints that it's all about social communication. The notion of animals using chemical scents to communicate with each other is hardly new. Dogs classically use urine to mark their territory, for example, as do many other creatures. But when it comes to peeing on oneself, researchers had thought physiological reasons might be as important as social ones. It seems they were wrong. Primatologist Kimran Miller and her research colleagues at the National Institutes of Health Animal Center in Poolesville, Maryland, monitored capuchin monkeys for ten months in a captive environment. The researchers would record daily the enclosure temperature and humidity and then note rates of urine washing. Their report, to be published in the American Journal of Primatology, shows that urine washing behaviours did not change with either temperature or humidity. ©2007 Nature Publishing Group

Keyword: Sexual Behavior; Aggression
Link ID: 10700 - Posted: 06.24.2010

Depression is a more disabling condition than angina, arthritis, asthma and diabetes, World Health Organization research shows. And those with depression plus a chronic illness, such as diabetes, fare particularly badly, the study of more than 245,000 people suggests. Better treatment for depression would improve people's overall health, the researchers concluded in the Lancet. Experts called for better funding for mental health services. Dr Somnath Chatterji and colleagues asked people from 60 countries taking part in the World Health Survey a variety of questions about their health, such as how they sleep, how much pain they have, and whether they have any problems with memory or concentration. Participants were also asked about how they manage with day-to-day tasks. After taking into account factors such as poverty and other health conditions, the researchers found that depression had the largest effect on worsening health. And people with depression who also had one or more chronic diseases had the worst health scores of all the diseases looked at or combinations of diseases. Dr Somnath Chatterji said: "The co-morbid state of depression incrementally worsens health compared with depression alone, with any of the chronic diseases alone, and with any combination of chronic diseases without depression. "These results indicate the urgency of addressing depression as a public health priority to reduce disease burden and disability, and to improve the overall health of populations." The team called on doctors around the world to be more alert in the diagnosis and treatment of the condition, noting that it is fairly easy to recognise and treat. (C)BBC

Keyword: Depression; Neuroimmunology
Link ID: 10699 - Posted: 09.08.2007

By Jennifer Couzin It's no secret that we humans are smarter than our primate relatives. But exactly how are we smarter? Experiments with chimpanzees, orangutans, and more than 100 German toddlers suggest that our social intelligence is what sets us apart from other apes, allowing us to build on our inborn intelligence. As intuitive as this might sound, the conclusion is controversial. Ph.D. student Esther Herrmann of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, along with her adviser, psychologist Michael Tomasello, and their colleagues, compared 106 juvenile and adult chimpanzees living in sanctuaries in Uganda and in the Republic of the Congo, 32 orangutans at a care center in Indonesia, and 105 2.5-year-olds from Germany. The participants were asked to perform an involved series of tests lasting 3 to 5 hours. Six tasks were social, meaning that one of the scientists took part and the children, chimps, or orangutans needed to discern social cues. The other 10 were physical, such as tracking down a reward (food for the apes and toys for the children) after it had been hidden. On the physical tasks, children performed no better than the chimps or orangutans. The chimps even outperformed the children on three tasks. © 2007 American Association for the Advancement of Science.

Keyword: Evolution
Link ID: 10698 - Posted: 06.24.2010

By Greg Miller Mice with a gene mutation linked to rare human cases of autism show a hallmark symptom of the disorder: impaired social interactions. The finding, published online today in Science, adds to recent evidence that defects in the synaptic connections between neurons can contribute to autism and related conditions. Autism is a widespread disorder characterized by social and communication difficulties and obsessive or repetitive behaviors. Scientists don't know what causes it, but genetics appears to be important. Variations in several genes have been implicated. For example, a 2003 study identified a mutation--a single-letter switch in the genetic code for a protein called neuroligin-3--in two Swedish brothers, one with autism and one with the related but milder Asperger syndrome. Neuroligin-3 resides at synapses, the communication points between neurons, but little is known about its function, let alone how it contributes to symptoms of autism. To investigate, researchers led by Katsuhiko Tabuchi and Thomas Südhof at the University of Texas Southwestern Medical Center in Dallas created a strain of mice with the same mutation found in the Swedish brothers. The mutant mice had normal activity levels and coordination, but when the researchers put mutant mice in an enclosure with a mouse that had been restrained in a small cage, they were unusually shy, spending less time sniffing and interacting with the caged mouse than did normal mice. (The mouse had to be restrained, because otherwise it would have initiated interactions with the mutants, confounding the test.) There was no difference between mutant and normal mice when it came to investigating an empty cage, however, and the mutants even outperformed normal mice on a test of spatial learning and memory, suggesting that their deficit was specific for social behavior. © 2007 American Association for the Advancement of Science.

Keyword: Autism
Link ID: 10697 - Posted: 06.24.2010

By Rebecca Morelle The mystery behind the tree rubbing antics of North America's grizzly bears may at last have been solved. A few select trees are used by grizzlies to perform strange rubbing rituals, but for years the reasons for this behaviour have baffled ecologists. Now, a study suggests that male grizzlies seeking mates are marking the trees to communicate with other males - possibly to dodge deadly bear battles. The work will be presented next week at a British Ecological Society meeting. Owen Nevin, a behavioural ecologist at Cumbria University, UK, who carried out the study, said: "A handful of trees ('rub trees') are used for years by different grizzlies who each approach the trees in exactly the same way. "They will step into the footprints of other bears that have approached the trees, urinating as they approach. "Then they rub their back on the tree, turn around and then bite the tree and claw it. Then they give it a 'bear hug' by rubbing their chest against it, and then they rub it with their back again." Many theories have been put forward as to why grizzlies are rubbing these trees: some thought they were using them to scratch an itch, others that they were trying to rub on tree sap to repel insects, while some thought they were using the trees to attract mates. Dr Nevin told the BBC News website: "Until now, we haven't really known which bears use these trees and why they use them." To investigate the bears' behaviour, Dr Nevin looked at a grizzly population living in a 150 sq km (58 sq miles) valley in British Columbia, Canada. He set up digital cameras, activated by infra-red sensors, at four frequently used rub trees and attached satellite collars to bears to track their movements. (C)BBC

Keyword: Sexual Behavior
Link ID: 10696 - Posted: 09.06.2007

By Andrea Thompson We remember the bad times better than the good because our emotions influence how we process memories, a new review of research shows. When people recall significant, emotional events in their lives, such as their wedding day or the birth of their first child, they're generally very confident about how well they remember the details of the event. But whether or not this confidence is warranted is debatable, because details remembered with confidence often aren’t exactly correct, according to the review of research on emotional memories. Memories are generally prone to distortion over time, but researchers have found some evidence to suggest that emotional memories are more resistant to the decay processes that wear away at all memories with time, says review author Elizabeth Kensinger of Boston College. "It's clear that there's something very kind of special and prioritized about how we remember those emotional experiences," said Kensinger, whose review is published in the August issue of the journal Current Directions in Psychological Science. Negative events may edge out positive ones in our memories, according to research by Kensinger and others. © 2007 MSNBC.com © 2007 Microsoft

Keyword: Learning & Memory
Link ID: 10695 - Posted: 06.24.2010

By ELISABETH ROSENTHAL Common food additives and colorings can increase hyperactive behavior in a broad range of children, a study being released today found. It was the first time researchers conclusively and scientifically confirmed a link that had long been suspected by many parents. Numerous support groups for attention deficit hyperactivity disorder have for years recommended removing such ingredients from diets, although experts have continued to debate the evidence. But the new, carefully controlled study shows that some artificial additives increase hyperactivity and decrease attention span in a wide range of children, not just those for whom overactivity has been diagnosed as a learning problem. The new research, which was financed by Britain’s Food Standards Agency and published online by the British medical journal The Lancet, presents regulators with a number of issues: Should foods containing preservatives and artificial colors carry warning labels? Should some additives be prohibited entirely? Should school cafeterias remove foods with additives? After all, the researchers note that overactivity makes learning more difficult for children. “A mix of additives commonly found in children’s foods increases the mean level of hyperactivity,” wrote the researchers, led by Jim Stevenson, a professor of psychology at the University of Southampton. “The finding lends strong support for the case that food additives exacerbate hyperactive behaviors (inattention, impulsivity and overactivity) at least into middle childhood.” Copyright 2007 The New York Times Company

Keyword: ADHD
Link ID: 10694 - Posted: 06.24.2010

By Shankar Vedantam Warnings from federal regulators four years ago that antidepressants were increasing the risk of suicidal behavior among young people led to a precipitous drop in the use of the drugs. Now a new study has found that the drop coincides with an unprecedented increase in the number of suicides among children. From 2003 to 2004, the suicide rate among Americans younger than 19 rose 14 percent, the most dramatic one-year change since the government started collecting suicide statistics in 1979, the study found. The rise followed a sharp decrease in the prescribing of antidepressants such as Prozac, Zoloft and Paxil after parents and physicians were confronted by a barrage of warnings from the Food and Drug Administration and international agencies. The data suggest that for every 20 percent decline in antidepressant use among patients of all ages in the United States, an additional 3,040 suicides per year would occur, said Robert Gibbons, a professor of biostatistics and psychiatry at the University of Illinois at Chicago, who did the study. About 32,000 Americans commit suicide each year. Thomas Insel, director of the National Institute of Mental Health, said, "We may have inadvertently created a problem by putting a 'black box' warning on medications that were useful." He added, "If the drugs were doing more harm than good, then the reduction in prescription rates should mean the risk of suicide should go way down, and it hasn't gone down at all -- it has gone up." © 2007 The Washington Post Company

Keyword: Depression
Link ID: 10693 - Posted: 06.24.2010

Using new software developed to investigate how the brains of dyslexic children are organized, University of Washington researchers have found that key areas for language and working memory involved in reading are connected differently in dyslexics than in children who are good readers and spellers. However, once the children with dyslexia received a three-week instructional program, their patterns of functional brain connectivity normalized and were similar to those of good readers when deciding if sounds went with groups of letters in words. “Some brain regions are too strongly connected functionally in children with dyslexia when they are deciding which sounds go with which letters,” said Todd Richards, a UW neuroimaging scientist and lead author of a study published in the current issue of the Journal of Neurolinguistics. “We had hints in previous studies that the ability to decode novel words improves when a specific brain region in the right hemisphere decreases in activation. This study suggests that the deactivation may result in a disconnection in time from the comparable region in the left hemisphere, which in turn leads to improved reading. Reading requires sequential as well as simultaneous processes.” Richards and co-author Virginia Berninger, a neuropsychologist, said temporal connectivity, or the ability of different parts of the brain to “talk” with each other at the same time or in sequence, is a key in overcoming dyslexia. Berninger, who directs the UW’s Learning Disabilities Center, compared dyslexia to an orchestra playing with an ineffective conductor who does not keep all the musicians playing in synchrony with each other.

Keyword: Dyslexia
Link ID: 10692 - Posted: 06.24.2010

By Matt Kaplan Does the anticipation of sex make animals better breeders? It appears to for quails. When researchers placed male quails in environments they learned to associate with mating, the birds sired more offspring than their untrained counterparts. The findings may provide clues to the evolution of conditioned learning in a variety of animals, including humans. Conditioned learning--or conditioning--was most famously demonstrated by Ivan Pavlov more than 100 years ago. Pavlov would ring a bell and then feed a dog. After a while, the dog began salivating every time he heard the bell, suggesting he had learned to associate the sound with food. Since then, researchers have studied how conditioning develops, but few have looked at how it might have evolved. Psychologist Michael Domjan and colleagues at the University of Texas, Austin, set out to explore the question. If conditioning improves the odds of reproducing, they reasoned, the trait would be adaptive and spread through the population. The researchers placed male quails, which readily breed in captivity, in boxes with green walls or tilted floors for 5 minutes and then introduced them to a female for a romantic liaison. After 5 days of conditioning, one male was placed in a green or tilted box for 5 minutes, and another male was placed in an unfamiliar box. Then both were introduced to a single female within minutes of each other. © 2007 American Association for the Advancement of Science.

Keyword: Sexual Behavior
Link ID: 10691 - Posted: 06.24.2010

Ewen Callaway A type of drug has been found that starts working much faster against depression than current medications. Behavioural and molecular tests in rats show that the compounds kick into action in days, rather than weeks. But the drugs — called serotonin receptor agonists — won't be replacing Paxil (paroxetine) soon. None has yet been approved for treating depression in humans, and some have been scrapped because of concerns over side effects. But researchers are still keen to pursue them, because the most popular type of antidepressant, called selective serotonin reuptake inhibitors (SSRI), can take up to two months to start easing symptoms. And for one-third of people with depression, they don't work at all. "This is a very good first step in identifying and potentially having a rapidly acting antidepressant," says Ronald Duman, a drug expert at Yale University in New Haven, Connecticut. "But there's a lot of work to done." SSRI's such as Prozac have become a household name over the past three decades, garnering many millions of prescriptions every year in adults, children and even pets. The drugs work by stopping neurons from greedily keeping hold of a neurotransmitter called serotonin, so allowing more of the pleasure-providing molecule to reach protein receptors in nearby brain cells. ©2007 Nature Publishing Group

Keyword: Depression
Link ID: 10690 - Posted: 06.24.2010

Our ability to hear is made possible by way of a Rube Goldberg-style process in which sound vibrations entering the ear shake and jostle a successive chain of structures until, lo and behold, they are converted into electrical signals that can be interpreted by the brain. Exactly how the electrical signal is generated has been the subject of ongoing research interest. In a study published in the September 6 issue of the journal Nature, researchers have shed new light on the hearing process by identifying two key proteins that join together at the precise location where energy of motion is turned into electrical impulses. The discovery, described by some scientists as one of the holy grails of the field, was made by researchers at the National Institute on Deafness and Other Communication Disorders (NIDCD), one of the National Institutes of Health (NIH), and the Scripps Research Institute in La Jolla, CA. When a noise occurs, such as a car honking or a person laughing, sound vibrations entering the ear first bounce against the eardrum, causing it to vibrate. This, in turn, causes three bones in the middle ear to vibrate, amplifying the sound. Vibrations from the middle ear set fluid in the inner ear, or cochlea, into motion and a traveling wave to form along a membrane running down its length. Sensory cells (called hair cells) sitting atop the membrane "ride the wave" and in doing so, bump up against an overlying membrane. When this happens, bristly structures protruding from their tops (called stereocilia) deflect, or tilt to one side. The tilting of the stereocilia cause pore-sized channels to open up, ions to rush in, and an electrical signal to be generated that travels to the brain, a process called mechanoelectrical transduction.

Keyword: Hearing
Link ID: 10689 - Posted: 09.06.2007