By Giorgia Guglielmi Neuroscience textbooks have long cast mitochondria as pure neuronal powerhouses: These bean-shaped organelles just crank out a cell’s energy. That picture, however, is starting to look incomplete. Mitochondria do far more than fuel neurons, a growing body of research suggests. They also appear to help synapses communicate, regulate neurotransmitter release and shape social behavior. Mitochondrial function has also been tied to autism and related neurodevelopmental conditions, though that link remains debated. Even memory formation may lean on these tiny, double-membraned structures, according to a study published in Nature Metabolism in February. Increasing mitochondrial metabolism boosted long-term memory in both fruit flies and mice. Mitochondria are “not just permissive but also instructive,” says Ezgi Hacisuleyman, assistant professor of molecular medicine at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, who was not involved in the February study. Her unpublished results show that mitochondrial proteins are translated near active synapses, for example. Over the past decade, work from Hacisuleyman and others has fast expanded the repertoire of mitochondria in the brain. Taken together, she adds, the findings put mitochondria “more in the center of how we think about brain function and memory.” Mitochondria may be central to brain function, but they are not central inside neurons. Many synapses sit hundreds of micrometers away from a cell’s soma, so small, mobile mitochondria must travel there to deliver fuel in the form of ATP. In dendrites, mitochondria often linger near spines, and activity recruits them to presynaptic boutons, where they help stabilize neurotransmitter release. © 2026 Simons Foundation

Keyword: Development of the Brain; Obesity
Link ID: 30310 - Posted: 07.04.2026

By Henry Taylor & The Conversation US You know that feeling when you walk into a room and immediately forget why you came in? Maybe you were there to fetch your keys. On your way to the room, you were thinking about grabbing your keys. But once you arrive, your keys have completely disappeared from your mind. This is sometimes known as the doorway effect, since it often strikes when you walk into a new room. Why does it happen? The answer has a lot to do with a faculty called working memory. Information gets stored in working memory when we need it for the tasks that we are engaged in right now (like remembering to grab your keys). What makes working memory so intriguing is its close link to consciousness. The doorway effect suggests that when information is removed from working memory, it immediately seems to leave consciousness. It also suggests that it is easy for information in working memory to be forgotten. The link between working memory and consciousness is getting increasing attention in psychology, philosophy and neuroscience. Could working memory somehow give rise to consciousness? In my new book, I explore the complex relationship between the two. Working memory: both rich and poor To understand the doorway effect, we’ll need to know a bit about working memory. One thing that makes working memory so special is that it’s so rich, both in terms of the information it has access to, and its processing power. According to recent models of working memory, it can draw information from sensory channels (vision, touch, smell etc), as well as from other memory systems such as long-term memory and also the brain’s system for processing language. In other words, working memory is where a lot of the information in your brain comes together. Once working memory has that information, there’s a lot it can do with it. Inside working memory are a host of different smaller systems for specific tasks, including visual and spatial reasoning (like solving a Rubik’s cube) and storing chunks of information (like a phone number). There’s even a “central executive” system (my favorite). The executive is like a merciless boss, assigning tasks to the different systems within working memory and keeping everything under control. © 2026 SCIENTIFIC AMERICAN

Keyword: Consciousness; Learning & Memory
Link ID: 30309 - Posted: 07.04.2026

By Libby Riddle A bear might seem like the scariest thing you could run into in a national park. But a new study suggests maybe you should be more worried about elk. Out of nearly 3,000 wildlife incidents in Canadian national parks, more than half involved an elk, researchers report July 2 in Frontiers in Conservation Science. But the risk of tangling with a given species also depended on what people were doing, say Holly Landles and conservation biologist Shashank Balakrishna of the University of York in England. Camping out? Be wary of elk grazing near your campsite. Quietly hiking or wildlife watching? Watch out for bears using the same trails. “By identifying situations where a potential conflict scenario is more likely, we can help visitors make informed decisions that improve safety whilst also reducing unnecessary disturbance to wildlife,” says Landles, who conducted this research as an undergraduate at York. Landles and Balakrishna analyzed 2,878 aggressive wildlife incidents from 2010 to 2023 involving five animals: black bears, grizzly bears, elk, coyotes and mule deer. Aggressive behaviors included chasing, attacking or bluffing a charge. The analysis identified which animal–human activity combinations were especially risky. Elk topped the list, involved in 62 percent of all the incidents. One of the riskiest combos was elk and camping — the animals turned up in 84 percent of campground incidents. This may be because Canada’s peak camping season aligns with when the animals mate and give birth — times of heightened aggression for the species. “Elk are herbivorous herd animals that don’t immediately inspire fear like a carnivore does,” Balakrishna says. Visitors may underestimate how aggressive they can be. © Society for Science & the Public 2000–2026.

Keyword: Aggression
Link ID: 30308 - Posted: 07.04.2026

By Jake Currie Memory loss is by far the most notorious symptom of Alzheimer’s disease, but it might not be the initial sign of the illness. According to a new study published in Nature Communications, there’s an even earlier tell—impaired cognitive flexibility. Cognitive flexibility is one of the brain’s executive functions governing our ability to switch between different tasks, adapt to novel situations, learn new rules, and so on. To study changes in this vital function, neuroscientists at Texas A&M University used mice genetically engineered to produce the amyloid-beta plaques associated with Alzheimer’s disease (5xFAD mice). The team conditioned the mice to learn that a particular action (pulling a lever) led to a reward (a delicious food pellet). They then changed the rules to find out how they reacted. Healthy mice had no trouble adapting to the new regime, but the 5xFAD mice struggled, often repeatedly pulling the original lever without receiving a reward. Importantly, these cognitive flexibility problems surfaced earlier than the kinds of memory problems typically associated with Alzheimer’s. “We found that this function was impaired before we could detect deficits in spatial memory,” study author Jun Wang said in a statement. Taking a closer look into the 5xFAD mice brains, the researchers discovered abnormally high levels of neuroactivity in the medial prefrontal cortex, a region involved in decision-making and behavioral flexibility. Previous research has shown this kind of hyperactivity can lead to amyloid-beta plaques piling up, which in turn makes neurons even more excitable. It basically leads to a positive feedback loop.

Keyword: Alzheimers; Attention
Link ID: 30307 - Posted: 07.04.2026

By Sarah Thau Hunger pangs build with activity in Agouti-related protein (AgRP) neurons, and when we eat, these cells fall silent, signaling to the body that it’s full. Until recently, researchers thought these neurons responded to calorie intake alone, but a new study shows fructose quiets them less effectively than glucose does, even though both simple monomeric sugars carry the same number of calories. “We were really surprised when we tested these different sugars and found that fructose looks much different than glucose,” says study investigator Amber Alhadeff, a member of the Monell Chemical Senses Center and adjunct assistant professor of neuroscience at the University of Pennsylvania. Fiber photometry recordings of individual AgRP neurons in mice consuming fructose or glucose solutions first tipped the lab off to the fact that fructose is the weaker inhibitor. The same difference surfaced when the team infused the solutions directly into the animals’ guts, controlling for the fact that the mice tended to take more licks of the glucose than fructose. Glucose does not require the vagus nerve to inhibit AgRP neurons, according to previous work from Alhadeff’s group, but fructose does, the new study demonstrates. This study is the first to show “that the brain is responding to these things in different ways, and with a real mechanistic underpinning,” says Martin Myers, professor of diabetes research at the University of Michigan Medical School, who was not involved in the research. “This is an absolutely fabulous lab that is doing things that few, if any, other people in the world can do.” Once the team discovered that fructose acts through the vagus nerve, Alhadeff’s graduate student Aaron McKnight hit the mechanistic ground running. He worked for five years, according to Alhadeff, to show that fructose activates the vagus nerve, releasing a hormone called PYY that signals Y2 receptor-expressing vagal afferent neurons and then inhibits AgRP neurons. Glucose does not lead to increased PYY levels, acting through gut-spinal afferent signaling—a separate peripheral pathway. © 2026 Simons Foundation

Keyword: Obesity
Link ID: 30306 - Posted: 07.01.2026

By Nora Bradford Mirrors are tricky. Even humans aren’t born with an intuitive understanding of them; we have to learn how they work. Now, scientists have discovered that the California two-spot octopus (Octopus bimaculoides) can also learn to use mirrors, researchers report June 3 in Current Biology. When brainstorming octopus experiments, Mary Kieseler, a neuroscientist at the University of Fribourg in Switzerland, had wondered whether the famously smart creatures could pass the mirror test, which evaluates if an animal can identify itself in a mirror. Because of the challenging logistics the mirror self-recognition test would entail underwater, Kieseler and her team decided to first study whether octopuses could use mirrors as a tool to do something they’re already great at. And octopuses are great at hunting prey. The team began by habituating three wild-caught octopuses to a mirror covering half their tank. They let the octopuses hide from the mirror and even explore the other half of the tank behind it. After the octopuses became comfortable with seeing their reflection and eating in front of the mirror, the team gave them a task: Find a hidden jar with a tasty crab inside, placed where the snack could be found using only its reflection in the mirror. Initially, the octopuses approached the mirror, then turned around to find their prey. But after about 10 to 12 trials, each animal learned to crawl directly to the crab without the mirror pit stop. When using real crabs, there was no way to know whether the octopuses might have been relying on smell or another nonvisual sense to hunt, so Kieseler and her team came up with one final test. Rather than using real crabs, the team used virtual ones. © Society for Science & the Public 2000–2026

Keyword: Intelligence; Learning & Memory
Link ID: 30305 - Posted: 07.01.2026

By K. R. Callaway Strutting and fluttering around cities, pigeons have adapted to an ever-shifting environment. But their environment isn’t the only thing that’s constantly changing. New research suggests the birds themselves avoid stability in their decision-making, instead choosing to live “at the edge of chaos.” As model species for learning and behavior, these birds are helping researchers test a century-old law about how humans and other creatures learn. When learning something new, people and animals alike tend to repeat behaviors that are rewarded. First proposed by Edward Thorndike in 1898, this principle is so well established in psychology that it's become known as the law of effect. But the law implies that beyond making a behavior more frequent, rewards also make it more consistent: reducing variability in the specific way behaviors are performed over time. Although scientists have repeatedly tested whether rewards increase the frequency of behaviors, their effect on consistency is less well studied. University of Iowa experimental psychologist Edward A. Wasserman and his colleagues decided to put it to the test in pigeons—a species that has been integral to the study of learning at the university’s Comparative Cognition Laboratory for more than 50 years. And the study’s results, published in the Journal of Experimental Psychology: Animal Learning and Cognition, suggest these birds experience variability as the spice of life. To see how rewarded behaviors vary, the researchers gave pigeons a series of five colorful buttons to peck. They could peck any buttons in any order, but as long as they pecked five times, a treat would appear. Based on previous theories of learning, the scientists expected the pigeons might eventually slip into a routine—perhaps choosing to repeat patterns they know work or simply pecking the button nearest to them five times. Instead they continued pecking in a variety of patterns. © 2026 SCIENTIFIC AMERICAN,

Keyword: Learning & Memory; Evolution
Link ID: 30304 - Posted: 07.01.2026

By Aimee Cunningham Reassuring evidence on acetaminophen’s safety during pregnancy keeps growing. A large, two-decade study in Hong Kong is the latest to find no link between use of the drug — known as Tylenol in the United States — and a risk of autism or attention-deficit/hyperactivity disorder in children. The lack of an association persisted no matter the trimester the drug was prescribed, the dose or the recommended frequency, researchers report June 29 in JAMA Internal Medicine. Joining several other analyses, including ones conducted in Sweden and Japan, the research adds to the body of evidence reporting no association between acetaminophen use in pregnancy and long-term neurodevelopmental disorders in children. All the studies compared siblings born to mothers who had taken the drug at some point, such that some siblings were exposed to the drug in utero and others weren’t. This approach accounts for the fact that both ADHD and autism are largely influenced by genetics. If acetaminophen were also a factor, researchers would expect a difference between siblings exposed to the drug and those not. None of the studies have found one. For the new study, the researchers pored over electronic health records from 2001 to 2023 for more than 700,000 pairs of mothers and children. Around 43 percent of the kids encountered acetaminophen in utero. The team focused on pairs of siblings that differed in exposure and used their records to follow the children for at least two years for autism diagnoses and at least five for ADHD. The autism analysis included more than 124,000 children, while the ADHD component had more than 97,000. Going a step further, the analysis also looked at the timing and amount of acetaminophen that was prescribed. © Society for Science & the Public 2000–2026.

Keyword: ADHD; Autism
Link ID: 30303 - Posted: 07.01.2026

By Michael Howerton Healthy brains may be built through a process of controlled damage and rapid repair. The most dangerous type of DNA damage is a regular feature of healthy early brain development, experiments in mice show. As newborn neurons squeeze through the cramped, narrow spaces of developing brain tissue, they break both strands of their DNA, researchers report June 17 in Nature. The breaks are repaired once neurons reach their destination, usually within a day. It’s a paradox of vulnerability and resilience. Newborn neurons routinely sustain a kind of damage that kills most cells, yet they repair it and emerge intact, the researchers found. The speed of the repair surprised the team. “Somehow neurons can repair [the damage] very quickly without any sign of mutations or bad effect,” says neurobiologist Mineko Kengaku of Kyoto University in Japan. “It seems to be a normal developmental event.” The breaks appear in areas of the genome that aren’t crucial, the team found, which in most cases allows neurons to survive and grow without lasting damage. “It is surprising that, during evolution, the mammalian brain acquires such a clever strategy,” Kengaku says. More research is needed to understand the implications beyond mice, but Kengaku says the effect might even be more pronounced in humans. “During development, neurons have to migrate, and if the brain size is larger, then neurons have to migrate longer distances,” she says. “It is quite likely that neurons in human brains probably generate more DNA damage during development” than neurons in mice brains do. But a flawless break-and-repair cycle is not always guaranteed, Kengaku says. When it fails or is incomplete, the damage could persist. These instances, she says, could help explain some neurological conditions later in life. © Society for Science & the Public 2000–2026.

Keyword: Development of the Brain; Neurogenesis
Link ID: 30302 - Posted: 06.27.2026

Ian Sample Science editor A scientist who decoded the vocalisations that a bird uses to communicate has won a $100,000 prize for making progress towards a world in which humans can talk to the animals – without being met with a blank response. Dr Julie Elie at the University of California, Berkeley, was awarded the 2026 Coller-Dolittle prize for two-way interspecies communication after working out the 11 core calls in the zebra finch vocabulary and their meanings. Her work revealed how the birds announce who they are and what they are doing, and recognise one another regardless of what they are saying by using individual signatures. She also found that at times, the birds confused calls with similar meanings more than those that sounded the same. “I’m really super-honoured,” Elie said on winning the prize, adding that she hoped the work was a step forwards in the “great endeavour” to communicate with animals. Prof Yossi Yovel, a zoologist at Tel Aviv University and chair of the panel of judges, said the work marked “a key moment in the field”. The prize was launched in 2024 by the Jeremy Coller Foundation, which promotes awareness of animal welfare and animal sentience, in partnership with Tel Aviv University. Beyond the annual prizes for progress, the foundation has established a $10m grand prize for cracking the problem of two-way human-animal communication. Elie decided to study zebra finches because they are so vocal – meaning they produce plenty of data. “The question I asked myself when hearing these chatty songbirds was what are they saying?” she said. For more than a decade, Elie observed and recorded the sounds the birds made and classified the calls according to the situation and the bird that made them. She then used machine learning to analyse what and how information was encoded in the calls. Finally, she ran tests that showed the birds agreed with her classification. © 2026 Guardian News & Media Limited

Keyword: Animal Communication; Language
Link ID: 30301 - Posted: 06.27.2026

By K. R. Callaway In the flatwoods of South Florida, tiny brown birds emerge from the underbrush to sing from the branches of pine trees. To human ears, their songs sound nearly identical, but any given population of these birds — Bachman’s sparrows — uses as many as 120 different song types to communicate. Like human language, birdsong is dynamic. Every avian generation makes choices about which songs to continue singing, which to improve upon and which to drop altogether. A single Bachman’s sparrow might learn only 48 of the songs used by its community, and for decades researchers have been trying to figure out how baby sparrows choose which songs to adopt. Previous studies have focused on social and cultural factors. During their critical song-learning phase of development, young songbirds imitate the adult males in their group who are successful in courtship or have elaborately ornamented plumage. Now, a new study of Bachman’s sparrows reveals another possible part of the equation: the physical environment. Trees, dense shrubs and even wind can scatter or block the transmission of some sound waves, and researchers suspect that young sparrows are less likely to latch onto degraded songs, leading in turn to some songs becoming rarer than others. “The rarer song types don’t propagate quite as well over distance than the common ones do,” said Rindy Anderson, a behavioral ecologist at Florida Atlantic University and an author of the study, which appeared on March 24 in the journal Bioacoustics. All the Bachman’s sparrow song types have a similar form, with a buzzing or whistling note followed by a trill. Some trills are faster or slower than others, and some complex songs contain trills of several frequencies. Researchers recorded a variety of rare and common sparrow songs and then rerecorded them playing in different environments — among dense trees, windy plains and other places that Bachman’s sparrows frequent but that could distort audio signals. Under these conditions, the researchers found that rarer songs did not propagate as well as common songs. © 2026 The New York Times Company

Keyword: Language; Evolution
Link ID: 30300 - Posted: 06.27.2026

By Phie Jacobs When Charles Darwin visited Ascension Island in 1836, he was perplexed by the vast numbers of green sea turtles (Chelonia mydas) nesting on its beaches. Every mating season, these intrepid reptiles leave their feeding grounds along the coast of Brazil and journey more than 2000 kilometers across the sea to lay their eggs on this tiny, remote island. How, Darwin later mused in a letter to Nature, did the animals find their way to a “speck of land in the midst of the great Atlantic Ocean?” Since then, scientists have uncovered convincing evidence that sea turtles can sense components of Earth’s geomagnetic field. Now, data collected using a new kind of tracking device lend further support to the idea that these animals use magnetic maps to navigate during their transoceanic voyages. But the system is far from perfect, researchers report today in Science Advances, which means migrating turtles must periodically reorient themselves after veering off course. The findings fit “very comfortably with what we know about turtle navigation,” says Kenneth Lohmann, a marine biologist at the University of North Carolina at Chapel Hill who wasn’t involved in the research. His team previously conducted laboratory studies demonstrating turtles can sense the strength of geomagnetic fields as well as their angle relative to the surface of Earth—potentially providing migrating turtles with a “bicoordinate” geomagnetic map of their surroundings. Exactly how good they are at using those coordinates in the open ocean, however, has been less clear. Graeme Hays, a marine ecologist at Deakin University, paid his own visit to Ascension Island back in the 1990s. While there, he and Paolo Luschi—now a biologist at the University of Pisa—worked to outfit green sea turtles with satellite tracking devices. Early on, Hays recalls, the pair recognized a significant limitation: Although these tags can accurately track a turtle’s path across the ocean, those data don’t necessarily reflect “where the animal is trying to go.” © 2026 American Association for the Advancement of Science.

Keyword: Animal Migration; Evolution
Link ID: 30299 - Posted: 06.27.2026

By Emily Anthes Humor is deeply personal. A punchline or a pratfall that leaves one person doubled over in delight might elicit blank stares from another. But laughter is universal, an innate instinct shared by humans everywhere. And not just humans. Chimps chuckle, gorillas guffaw, bonobos bust a gut. All the planet’s great apes laugh, and they often do so in the same kind of regular, repeating rhythm that humans do, scientists found in a small new study. The research sheds light on how laughter evolved with and among great apes, becoming faster and more variable in humans than in these other primate species. While nonhuman apes appeared to laugh in ways that were largely fixed, humans were more flexible in their expressions of mirth, changing up the tempo of their chuckles depending on the circumstance, the scientists found. “I think we can say we are the masters of laughter,” said Chiara De Gregorio, a research fellow at the University of Warwick in Britain and an author of the study. “We can have a small, polite laugh in front of the Queen of England, and then we are in the pub with our friends, and we laugh so much in a different way. We can even laugh in a way that communicates to the other person that we actually didn’t find the joke they said funny.” This wide-ranging repertoire requires significant vocal flexibility and control — the same skills that humans would have needed for spoken language. The study demonstrates the “uniqueness of human laughter,” said Greg Bryant, a cognitive scientist at the University of California, Los Angeles, who was not involved in the new research. “It provides a window into human vocal evolution.” In the new study, which was published on Thursday in the journal Communications Biology, the researchers analyzed the recorded laughter of four children and 13 young, captive apes: four orangutans, two gorillas, three bonobos and four chimpanzees. Some of the recordings featured laughter produced during play, while others captured laughter elicited by tickling. © 2026 The New York Times Company

Keyword: Emotions; Evolution
Link ID: 30298 - Posted: 06.27.2026

By Calli McMurray Kanga the marmoset places her hand on the lever and looks at Dodson, a fellow marmoset working with her on a task. As it becomes apparent that Dodson is ready to pull his own lever, neurons in Kanga’s dorsomedial prefrontal cortex ramp up their firing. The activity reaches its peak as Kanga decides to pull the lever, in sync with her partner. As a reward for their coordinated effort, both marmosets earn a sip of liquid marshmallow fluff. This type of neuronal computation underlies the “evidence accumulation model,” a major theory of how perceptual decisions are made: The brain gathers evidence and executes a decision once the evidence reaches a certain threshold. The marmoset study, which was published last month in Neuron, demonstrates that the model also applies to social decisions. This result wasn’t a given; making a social decision relies on the changing behavior of another animal, and the actions of the decider can influence what the other animal does, says study investigator Monika Jadi, associate professor of psychiatry and neuroscience at Yale University. “It’s a very recurrent system,” she says. Support for the evidence accumulation model has come largely from highly controlled experiments; the fact that the same activity pattern appears in a social and less constrained task “implies that this is a generalizable computation,” says Timothy Hanks, associate professor of neurology at the University of California, Davis, who was not involved in the work. Social, perceptual, foraging and other decisions are “categories we’ve created,” but there may not be anything “acutely different” about them, says Cory Miller, professor of psychology at the University of California, San Diego, who was not involved in the study. “I love this line of work; I think it’s super powerful.” © 2026 Simons Foundation

Keyword: Learning & Memory; Emotions
Link ID: 30297 - Posted: 06.27.2026

A San Francisco startup with ties to Elon Musk’s Neuralink has started testing its brain implant to detect and treat cancer in humans. Coherence Neuro says it temporarily placed its coin-sized implant in the brains of three people undergoing surgery to have brain tumors removed at the Royal Melbourne Hospital in Australia. The implant was in place for roughly 30 minutes before being removed, providing an important safety check before the device can be implanted long-term in patients with brain cancer. Known as a brain-computer interface, the Coherence Neuro device is designed to sense the unique electrical signals of tumors and deliver mild electrical stimulation to prevent their growth. In the time the implant was in the patients’ brains, the company was able to see how it performed for a short period. (The patients had consented prior to surgery.) Matthew MacDougall, Neuralink’s head neurosurgeon, is an adviser and investor in Coherence. Rory Murphy, a neurosurgeon at the Barrow Neurological Institute in Arizona who is an investigator in one of Neuralink’s trials, is also slated to be involved in future trials of the Coherence device. The idea behind treating brain tumors with electrical stimulation comes from the long-held observation that cancerous tissue has distinctive electrical properties. “These are electrical conditions, just like epilepsy, just like depression. This is a network problem in the brain,” says Ben Woodington, chief executive officer and cofounder of Coherence. © 2026 Condé Nast.

Keyword: Biomechanics
Link ID: 30296 - Posted: 06.24.2026

By Jackie Rocheleau The cerebellum, the wizened “little brain” nestled in the base of the skull, may help keep us sharp as we age. Regions at the back of the cerebellum that resisted shrinkage with age were tied to better mental functioning, or cognition, even in people in the early stages of Alzheimer’s disease, researchers report June 10 in Nature Neuroscience. Though traditionally thought of as a movement control center, scientists now know the cerebellum is a key player in cognition. Researchers also know that parts of the cerebellum don’t age in unison, but the aging cerebellum is a relatively new area of research. In the new study, the team first analyzed brain scans and cognitive test scores from more than 700 U.S. adults whose data was collected as part of the Human Connectome Project, a brain mapping initiative. The test measured abilities including short-term memory, attention, language and visualizing 3-D objects. A clear trend emerged: The cerebellum tended to be smaller with increasing age, but the bigger the cerebellum, particularly in regions in the rear of the little brain, the higher the score on cognitive tests. The trend held even after adjusting for the different levels of education among participants, Princeton University neuroscientist Frederick d’Oleire Uquillas and colleagues report. The researchers found the same link in more than 35,000 adults in the U.K. Biobank, a biomedical database. The findings point to a larger cerebellum preserving cognition with greater age, says d’Oleire Uquillas. The researchers confirmed that scans of the larger cerebellums showed more brain tissue and connections between nerve cells, a © Society for Science & the Public 2000–2026.

Keyword: Alzheimers
Link ID: 30295 - Posted: 06.24.2026

Zoe Beketova When Adam Douglass began to study the tiny, transparent fish in the Danionella genus about 10 years ago, he had to get his animals from an out-of-state fish shop, where they were sold as an exotic pet breed. “The only information at all about trying to grow them in captivity came from online,” says Douglass, a neurobiologist at the University of Utah. Compared with zebrafish, which by that point had been a model species for biology research for decades, Danionella was little known to scientists. How things have changed. Last week, the Janelia Research Campus, the in-house research arm of the behemoth Howard Hughes Medical Institute (HHMI), announced a 10-year, roughly $1 billion research effort focused on using Danionella as a model for how brain cells and circuits drive complex behaviors in vertebrates. The effort will also draw on cutting-edge artificial intelligence (AI) tools to make sense of all the new data on the fish. “I think this is one of the most exciting opportunities that we’ve faced in the entire history of Janelia,” says neuroscientist Nelson Spruston, Janelia’s vice president and executive director. “There are a lot of structures in the brain and the rest of the body of fish that are identifiably similar to those of humans,” he adds, and there’s a long history of simple model organisms “leading to important insights that eventually result in cures and treatments for devastating diseases.” Danionella’s growing popularity comes from one (literally) clear advantage: Unlike zebrafish, which are transparent only for the first few weeks of their 3- to 4-year lives, Danionella remain so, meaning their brain is still visible—and easier to image—when they reach adulthood and engage in behaviors such as schooling, navigation, and courtship. The fish, only about the size of a grain of rice, never grow scales, develop pigmentation, or form a complete, bony skull. “All of these features that stand in the way of being able to get photons into and out of your skull [for imaging] are not there,” says Douglass, who has watched Danionella become a focus of dozens of labs worldwide

Keyword: Development of the Brain; Brain imaging
Link ID: 30294 - Posted: 06.24.2026

By Simon Makin A new tool makes it possible to probe brain circuit function without the kind of external stimulation required in optogenetics and chemogenetics. The method uses engineered electrical synapses to edit brain circuits. These designer synapses function in living mice, altering activity in cells, circuits and networks, with corresponding effects on behavior. In contrast to tools that involve external stimulation, the result is autonomous. “Here, all the information is completely natural; it’s only how the brain manipulates this information that’s being altered,” says Ithai Rabinowitch, assistant professor of neurobiology at the Hebrew University of Jerusalem, who was not involved in the work. “This is really important, in my view.” The technique, called LinCx (long-term integration of circuits using connexins) could be used to investigate relationships between circuit structure and function, as well as the duties of natural electrical synapses. “It’s potentially a useful tool if it’s used intelligently and thoughtfully to ask questions about the role of electrical synapses in brain circuits,” says Eve Marder, professor of biology at Brandeis University, who was not involved in the study. Electrical synapses consist of gap junctions that, in vertebrates, are composed of connexin proteins, of which there are 21 isoforms in humans. These proteins sit in the membranes of touching cells, docked together to create channels that ions pass through, coupling the cells’ activity. Gap junctions in invertebrates are composed of innexins, which don’t interact with connexins, so expressing a mammalian connexin in Caenorhabditis elegans enabled researchers to rewire an olfactory circuit and flip the worms’ behavior from odor attraction to avoidance, according to a 2014 study. © 2026 Simons Foundation

Keyword: Drug Abuse; Brain imaging
Link ID: 30293 - Posted: 06.24.2026

Nicola Davis Science correspondent From “Howdy” to “G’day”, English – like other languages – is rich in dialects. Now researchers have found sperm whales on different sides of the Mediterranean show similar variations in their vocalisations. Sperm whales communicate vocally using sequences of short clicks called codas. However, the rhythmic pattern of these clicks, known as the dialect, can differ between different matriarchal groups. Crucially, one group of sperm whales will only associate with another if they share the same dialect and hence belong to the same “vocal clan”. “The dialect is used to form social structures, within which these animals will cooperate,” said Dr Luke Rendell, of the University of St Andrews and a co-author of the new study, noting similarities in how humans might be more comfortable striking up a conversation with someone who sounds similar to themselves. a whale Now Rendell and colleagues say they have discovered two different dialects among Mediterraean sperm whales – a small, endangered population of a few thousand individuals that are thought to have first entered these waters about 20,000 years ago. What’s more, they say the finding offers new insights into how sperm whale dialects arise. Writing in the journal Proceedings of the Royal Society B, the team note genetic studies have previously suggested Mediterranean sperm whales have become isolated from other sperm whales. There are also signs that mating between those in the western and eastern Mediterranean basins is restricted, although individuals have been spotted moving between the two. © 2026 Guardian News & Media Limited

Keyword: Animal Communication; Language
Link ID: 30292 - Posted: 06.24.2026

Max Kozlov In the fraction of a second before a person speaks, their brain weaves together complex grammar, precise vocabulary and the underlying meaning of the language. Now, researchers have tracked the electrical crackle of individual brain cells in real time during unscripted conversations, capturing how sentences are built before a single word is spoken. By observing these neurons in a region of the human brain called the frontotemporal cortex, scientists have discovered that individual brain cells act as specialized linguistic building blocks. “We used to think language was this diffuse, whole-network phenomenon,” says Ziv Williams, a neurosurgeon at Massachusetts General Hospital (MGH) in Boston and co-author of the study. “But it turns out you have specific neurons that only care if a word is a noun, or only care if a phrase is ending.” The work was published today in Nature1. To capture this activity, Williams and his colleagues used electrodes that were temporarily implanted in people with epilepsy to monitor their seizures. Because these participants were awake and speaking freely, the team could observe how the brain operated as they spoke. Neuroscientist Jing Cai, also at MGH, says that this set-up provided a rare opportunity to eavesdrop on the cellular processes that underlie speech, capturing details that standard brain-imaging devices cannot obtain. Access to such data provides a “rare” glimpse into the biological machinery that governs speech, says Angela Friederici, a neuropsychologist at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, Germany. © 2026 Springer Nature Limited

Keyword: Language
Link ID: 30291 - Posted: 06.20.2026