By Jennifer Couzin Can fat--even a lot of it--be healthy? A provocative study of fat transplants in mice suggests for the first time that the answer may be yes. Although some kinds of fat are known to be worse than others, no one had directly investigated whether certain types of fat might be a good thing. Researchers say that the work is preliminary but intriguing. For most overweight people, excess fat sits in one of two areas: deep inside the abdomen (visceral fat) or around the hips and legs (subcutaneous fat). Researchers have recognized for some time that visceral fat is the greater evil. People with lots of it are much more prone to diabetes, heart disease, and other problems than people with excess subcutaneous fat. But it's not clear exactly why. Is the fat itself different, or does its location in the body matter? To probe this question, C. Ronald Kahn, director of obesity research at the Joslin Diabetes Center in Boston, and his colleagues devised a relatively simple experiment. They transplanted fat in 42 naturally plump, healthy mice. The mice were divided into four groups that underwent different types of operations. In some, the researchers added visceral or subcutaneous fat to the abdomen. In others, they tucked visceral fat or subcutaneous fat under the animals' flanks, the rough equivalent to the hips. Thirteen other animals formed a control group; they were operated on but didn't receive extra fat. © 2008 American Association for the Advancement of Science.

Keyword: Obesity
Link ID: 11605 - Posted: 06.24.2010

Can Double Hearing Eric Bland -- A device screwed into the skull that transmits sound via bone can improve hearing in patients with certain kinds of hearing loss by as much as 50 percent, according to the largest study of devices, known as bone-assisted (or bone-anchored) hearing aids, or BAHAs. "This is a very important technology for a number of patients who have difficulty hearing," said Daniel Lee, a doctor at the Massachusetts Ear and Eye Infirmary in Boston, Mass., who was not involved in the study. "Patients are getting better choices for improving their hearing," said V. Suzanne Jeter, a researcher at Loyola University who presented the study at the 10th International Conference on Cochlear Implants and Other Implantable Auditory Technologies in San Diego. BAHAs have been used for years to restore hearing to patients who suffer from outer and middle ear problems like tumors, chronic infection, congenital disorders and other problems that stop sound from entering the inner ear. Unlike cochlear implants, the device cannot help deaf patients whose inner ear, which contains three tiny bones that contribute to hearing, has been damaged or destroyed. © 2008 Discovery Communications, LLC.

Keyword: Hearing
Link ID: 11604 - Posted: 06.24.2010

Alison Motluk Early child abuse may forever change the way genes are expressed in the brain, suggests a postmortem study of people who died by suicide. It is now well established that it isn't just what genes we inherit, but how they are turned on and off that influences our development. Most of these control switches are thrown before we are born, but some are set in early life, and to a lesser degree, throughout our lives. Genes are switched off when methyl groups are added to our DNA. Studies have shown that diet, stress and even maternal care can influence these "epigenetic" changes. In 2004, for instance, Moshe Szyf and his colleagues at McGill University in Montreal showed that rat pups neglected by their mothers had different levels of methylation and different stress responses from those that were well-cared for. They also showed that, with careful interventions, this could be reversed. Could early care in humans also affect methylation levels? Szyf knew that a sizable proportion of people who commit suicide were abused or neglected early in life. So his team examined the brains of 13 suicide victims who had a history of early neglect or abuse, and compared them to 11 age and gender matched controls, who had had normal upbringings but had died in sudden accidents. © Copyright Reed Business Information Ltd.

Keyword: Stress; Depression
Link ID: 11603 - Posted: 06.24.2010

Heidi Ledford It’s a classic mistake: you arrive at the grocery store hungry, and everything seems irresistible. Researchers have now worked out how a hunger-induced hormone called ghrelin can make all that food seem so desirable. The hormone stimulates the same ‘reward centres’ of the brain that have been linked to drug-seeking behaviour, they say. But it also activates regions of the brain involved with making memories: people injected with ghrelin remember pictures of food more clearly a day later. The appetite-stimulating effects of ghrelin are already being tested to see if the hormone can encourage eating in cancer patients. And inhibiting ghrelin has been discussed as one way to treat obesity. But the new results, published this week in Cell Metabolism 1, suggest that drugs that block ghrelin may have unwanted effects on memory, says study author Alain Dagher of McGill University in Montreal, Canada. Ghrelin was already known to trigger hunger: people given a ghrelin injection will pile their plates higher when turned loose on an all-you-can-eat buffet. Patients with the rare genetic disorder Prader-Willi syndrome have abnormally high levels of ghrelin and sometimes eat without ever feeling sated; some evenrupture their stomachs. © 2008 Nature Publishing Group

Keyword: Obesity; Learning & Memory
Link ID: 11602 - Posted: 06.24.2010

Parents of autistic children are twice as likely to have been hospitalized for a serious mental disorder than the parents of children without the disorder, suggests new research. A review of Swedish birth and hospital records by U.S. researchers reveals that if a child is autistic, their parents are twice as likely as other parents to have been hospitalized for a psychiatric disorder like schizophrenia. Depression and personality disorders were more common among mothers of autistic children (1.2 times more likely) than among mothers of non-autistic kids, suggests the study, published in Monday's issue of the journal Pediatrics. The study looked at 1,237 children born between 1977 and 2003 who were diagnosed with autism before age 10. To be deemed autistic, the children all had to have received a diagnosis of autism disorder, Asperger Syndrome or pervasive developmental disorder. Asperger Syndrome is a variant of autism in which individuals often exhibit extensive knowledge of a specific interest. Symptoms of pervasive developmental disorder include impairments in social interaction, imaginative activity, verbal and non-verbal communication skills, and a limited number of interests and activities that tend to be repetitive. © CBC 2008

Keyword: Autism; Genes & Behavior
Link ID: 11601 - Posted: 06.24.2010

By HENRY FOUNTAIN Songbirds have long been studied for insight into how the brain learns motor tasks — in a bird’s case, singing its characteristic song. Juvenile birds babble in screechy random bursts before they eventually develop a tonally and rhythmically precise song. Researchers have long known that a pathway called the high vocal center, or H.V.C., controls adult song, but whether that same pathway is responsible for babbling and changes as the bird ages has been an open question. “The general view that I had and others in the field had is that vocalization at any age is a function of the H.V.C.,” said Michale S. Fee, an associate professor at the Massachusetts Institute of Technology who has studied bird song for about a decade. But Dr. Fee and two graduate students, Dmitriy Aronov and Aaron S. Andalman, have reached a different conclusion. In experiments on zebra finches, they showed that the H.V.C. had no bearing on babbling. Instead, they report in Science, the behavior is controlled by a different circuit, with the tongue-twisting name of lateral magnocellular nucleus of the nidopallium, or LMAN. Copyright 2008 The New York Times Company

Keyword: Animal Communication; Language
Link ID: 11600 - Posted: 06.24.2010

More evidence is being put forward that breastfed babies eventually become more intelligent than those who are fed with formula milk. Canada's McGill University found breastfed babies ended up performing better in IQ tests by the age of six. But the researchers were unsure whether it was related to the breast milk itself or the bond from breastfeeding. The study of nearly 14,000 children is the latest in a series of reports to have found such a positive link. However, one problem has been that some of the research has struggled to identify whether the findings were related to the fact that mothers from more affluent backgrounds were more likely to breastfeed and it was factors related to the family circumstances that was really influencing intelligence. But the latest study attempted to take this into account by following the progress of children born in hospitals in Belarus, some of which ran breastfeeding promotion schemes to boost rates across all groups. They found that those who breastfed exclusively for the first three months - with many also continuing to 12 months - scored an average of 5.9 points higher on IQ tests in childhood. Teachers also rated these children significantly higher academically than control children in both reading and writing, the Archives of General Psychiatry reported. Lead researcher Professor Michael Kramer said: "Long-term, exclusive breastfeeding appears to improve children's cognitive development." (C)BBC

Keyword: Development of the Brain; Intelligence
Link ID: 11599 - Posted: 05.06.2008

Older people who have low levels of Vitamin D may be at a higher risk of depression, a new study has found. The new research shows that people deficient in vitamin D have high levels of parathyroid hormone, which has been linked to depression. The researchers estimate that 13 per cent of all people over 65 are depressed. Dutch scientists measured the blood levels of vitamin D and parathyroid hormones in 1,282 study participants between the ages of 65 and 95. They found that 26 of them were suffering from a major depressive disorder, 169 had minor depression and 1,087 did not suffer from depression. The study found that 38.8 per cent of men and 56.9 per cent of women had insufficient vitamin D levels. In those people who had both major and minor depression, vitamin D levels were 14 per cent lower than in people who did not suffer from depression. © CBC 2008

Keyword: Depression
Link ID: 11598 - Posted: 06.24.2010

By HOWARD MARKEL, M.D. Like most patients assigned to my substance abuse clinic these days, John, a stylish 22-year-old cosmetology student, did not arrive voluntarily. After two drunken driving violations, one in which another motorist was injured, a judge ordered John to attend a weekly recovery group I conduct for young adults facing similar legal troubles. But that was hardly the biggest stick the judge had at his disposal. “This Scram keeps me from even thinking about drinking,” John immediately told me as he raised a pant leg and pointed to a boxy plastic ankle bracelet that looked neither cool nor comfortable. Scram, for Secure Continuous Remote Alcohol Monitor, records the wearer’s alcohol intake by measuring air and perspiration emissions from the skin every hour. It detects blood alcohol levels as low as 0.02 percent, which corresponds to one drink or less an hour, and can even tell when the alcohol was consumed. Once a day, John has to be near a modem so it can transmit data from the last 24 hours to a monitoring agency and his probation officer. Copyright 2008 The New York Times Company

Keyword: Drug Abuse
Link ID: 11597 - Posted: 06.24.2010

By Sandra G. Boodman Bruce Munro wonders how things might have turned out if he hadn't lost it and dialed 911. The retired obstetrician had watched with mounting alarm as his wife, Bettie, seemed to get sicker by the day. For decades her health had been stable, regulated by medicines she took to control her cholesterol, blood pressure, Type 2 diabetes, a thyroid condition and a mood disorder. But in March 2006, Bettie Munro had developed a tremor that became very bad very fast. Doctors assumed she was suffering from a rapidly progressive case of Parkinson's disease, but the neurologist treating her was baffled about why the increasingly potent drugs he prescribed didn't seem to help. On Dec. 22, 2006, while Munro was getting his wife dressed for the day, he snapped. She had fallen three times and could no longer feed herself. "I thought, 'This is it, I can't handle this at home,' " Munro recalled. He picked up the phone and called for help. An ambulance whisked Bettie Munro from their house in a Loudoun County retirement community to Inova Loudoun Hospital. © 2008 The Washington Post Company

Keyword: Movement Disorders; Schizophrenia
Link ID: 11596 - Posted: 06.24.2010

By CARL ZIMMER “Why are humans so smart?” is a question that fascinates scientists. Tadeusz Kawecki, an evolutionary biologist at the University of Fribourg, likes to turn around the question. “If it’s so great to be smart,” Dr. Kawecki asks, “why have most animals remained dumb?” Dr. Kawecki and like-minded scientists are trying to figure out why animals learn and why some have evolved to be better at learning than others. One reason for the difference, their research finds, is that being smart can be bad for an animal’s health. Learning is remarkably widespread in the animal kingdom. Even the microscopic vinegar worm, Caenorhadits elegans, can learn, despite having just 302 neurons. It feeds on bacteria. But if it eats a disease-causing strain, it can become sick. The worms are not born with an innate aversion to the dangerous bacteria. They need time to learn to tell the difference and avoid becoming sick. Many insects are also good at learning. “People thought insects were little robots doing everything by instinct,” said Reuven Dukas, a biologist at McMaster University. Copyright 2008 The New York Times Company

Keyword: Learning & Memory; Evolution
Link ID: 11595 - Posted: 06.24.2010

By ALIYAH BARUCHIN A formerly controversial high-fat diet has proved highly effective in reducing seizures in children whose epilepsy does not respond to medication, British researchers are reporting. As the first randomized trial of the diet, the new study lends legitimacy to a treatment that has been used since the 1920s but has until recently been dismissed by many doctors as a marginal alternative therapy. “This is the first time that we’ve really got Class 1 evidence that this diet works for treatment of epilepsy,” said Dr. J. Helen Cross, professor of pediatric neurology at University College London and Great Ormond Street Hospital. She is a principal investigator on the study, which will appear in the June issue of The Lancet Neurology. Though its exact mechanism is uncertain, the diet appears to work by throwing the body into ketosis, forcing it to burn fat rather than sugar for energy. Breakfast on the diet might consist of bacon, eggs with cheese, and a cup of heavy cream diluted with water; some children drink oil to obtain the fats that they need. Every gram of food is weighed, and carbohydrates are almost entirely restricted. Breaking the diet with so much as a few cookies can cause seizures to flare up. Copyright 2008 The New York Times Company

Keyword: Epilepsy; Obesity
Link ID: 11594 - Posted: 06.24.2010

By EDWARD ROTHSTEIN When it comes to LSD, I have to confess: I inhaled. But I inhaled like so many other denizens of the 1960s and early ’70s, whether they actually took the drug or not. I inhaled because you couldn’t fail to inhale. LSD — its aura if not its substance — was a component of the air we breathed. This hallucinogen infused the exhalations of musicians, philosophers, advertisers and activists. There seemed nothing “counter” about this culture; it was prevalent. At the time there seemed to be as many head shops in New York as there are Starbucks now; acid rock played in those darkened spaces to acid heads, as beams of black light caused DayGlo Op-Art images to shimmer dizzyingly. Typefaces ballooned and swooped, melting across posters and album jackets in drug-induced swoons. Lucy was in the sky with diamonds, the Byrds were eight miles high, the Magical Mystery Tour was overbooked; Carlos Castaneda played out his fantasies. The era’s hallmark drug was championed with as much messianic fervor as the era’s countercultural politics. And I, and seemingly everyone else I knew, ingested that culture even if not the drug itself, not even realizing how strange that culture was. It seems even stranger with the passing of time. So while the death at 102 last week of Albert Hofmann may have tempted some to resurrect tales of spiritual adventures under the influence, or to invoke the now familiar quip that if you can remember the ’60s you weren’t there, there are other flashbacks — LSD-induced or not — to consider. Copyright 2008 The New York Times Company

Keyword: Drug Abuse
Link ID: 11593 - Posted: 06.24.2010

By Stephanie Reitz AMHERST, Mass. - One gray squirrel, its bushy tail twitching, barked a warning as another scrounged for food nearby. It was an ordinary spring day at Hampshire College, except that the rodent issuing the warning was powered by amps, not acorns. Dubbed "Rocky'' after the cartoon character, the robo-squirrel is working its way into Hampshire's live-squirrel clique, controlled by researchers several yards away with a laptop computer and binoculars. Sarah Partan, an assistant professor in animal behavior at Hampshire, hopes that by capturing a close-up view of squirrels in nature, Rocky will help her team decode squirrels' communication techniques, social cues and survival instincts. Rocky is among many robotic critters worldwide helping researchers observe animals in their natural environments rather than in labs. The research could let scientists better understand how animals work in groups, court, intimidate rivals and warn allies of danger. © 2008 Microsoft

Keyword: Animal Communication; Aggression
Link ID: 11592 - Posted: 06.24.2010

By Rob Stein Rocco Turso was injecting himself with insulin three times a day, swallowing pills twice daily and restricting his diet. But his diabetes was still out of control, blurring his vision, making his feet numb and sapping his energy. So he decided to try an experimental operation. Within days, his blood sugar was normal and he was off all his medications. "It's been truly amazing," said Turso, 62, a construction superintendent from Harrison, N.Y. "I use the word 'miracle.' The diabetes was killing me. It's given me back my life." Turso is one of a handful of Americans who have undergone a novel procedure that proponents say appears to offer the most important advance since the discovery of insulin in treating one of the most common chronic diseases. "It's extremely promising," said Madhu Rangraj, chief of laparoscopic surgery at the Sound Shore Medical Center in New Rochelle, N.Y., who performed the operation bypassing part of Turso's small intestine in March. "It's a surgical solution to diabetes." While many surgeons share Rangraj's enthusiasm, and some diabetes experts agree that the operation and similar ones may lead to fundamental new insights into the disease, other experts remain cautious. Much more research is needed, they say, to validate the effectiveness of the procedures. They worry that the operations will start to proliferate before their long-term safety and effectiveness have been proven, as often occurs with novel surgeries. © 2008 The Washington Post Company

Keyword: Obesity
Link ID: 11591 - Posted: 06.24.2010

By JANET RAE-DUPREE HABITS are a funny thing. We reach for them mindlessly, setting our brains on auto-pilot and relaxing into the unconscious comfort of familiar routine. “Not choice, but habit rules the unreflecting herd,” William Wordsworth said in the 19th century. In the ever-changing 21st century, even the word “habit” carries a negative connotation. So it seems antithetical to talk about habits in the same context as creativity and innovation. But brain researchers have discovered that when we consciously develop new habits, we create parallel synaptic paths, and even entirely new brain cells, that can jump our trains of thought onto new, innovative tracks. Rather than dismissing ourselves as unchangeable creatures of habit, we can instead direct our own change by consciously developing new habits. In fact, the more new things we try — the more we step outside our comfort zone — the more inherently creative we become, both in the workplace and in our personal lives. But don’t bother trying to kill off old habits; once those ruts of procedure are worn into the hippocampus, they’re there to stay. Instead, the new habits we deliberately ingrain into ourselves create parallel pathways that can bypass those old roads. Copyright 2008 The New York Times Company

Keyword: Learning & Memory
Link ID: 11590 - Posted: 06.24.2010

Michael Hopkin The number of fat cells in your body remains constant throughout your adult life, a new study has found. The discovery suggests that the process of weight gain may be fundamentally different in adults and in children. Adults who gain or lose weight may do so through changes in the size of the fat cells, also called adipocytes, that constitute fatty deposits in the body. Children, on the other hand, may put on extra fat by increasing the overall number of these cells in the body. This may mean that people who got fat during childhood may find it more difficult to shift the weight later in life, compared to those who piled on the pounds as adults, suggests Kirsty Spalding of the Karolinska Institute in Stockholm, Sweden, who led the new research. Although the number of fat cells remains constant in adulthood, Spalding and her team found that it is not the same cells persisting for ever. There is a dynamic process of cell death and replenishment. © 2008 Nature Publishing Group

Keyword: Obesity
Link ID: 11589 - Posted: 06.24.2010

A special high-fat diet helps to control fits in children with epilepsy, a UK trial suggests. The number of seizures fell by a third in children on the "ketogenic" diet, where previously they had suffered fits every day despite medication. The diet alters the body's metabolism by mimicking the effects of starvation, the researchers reported in the Lancet Neurology. The researchers called for the diet to be more widely available on the NHS. It is the first trial comparing the diet with routine care, even though it has been around since the 1920s. Children are given a tailored diet very high in fat, low in carbohydrate and with controlled amounts of protein. It is not exactly clear how it works but it seems that ketones, produced from the breakdown of fat, help to alleviate seizures. A total of 145 children aged between two and 16 who had failed to respond to treatment with at least two anti-epileptic drugs took part in the study. Half started the diet immediately and half waited for three months. The number of seizures in the children on the diet fell to two-thirds of what they had been, but remained unchanged in those who had not yet started the diet, the researchers reported. Five children in the diet group saw a seizure reduction of more than 90%. However, there were some side-effects including constipation, vomiting, lack of energy and hunger. Professor Helen Cross, study leader and consultant in neurology at Great Ormond Street Hospital in London, said the diet had been around for a long time but had fallen out of favour because it was thought to be too difficult to stick to. (C)BBC

Keyword: Epilepsy
Link ID: 11588 - Posted: 05.03.2008

By KATIE HAFNER SAN FRANCISCO — When David Bunnell, a magazine publisher who lives in Berkeley, Calif., went to a FedEx store to send a package a few years ago, he suddenly drew a blank as he was filling out the forms. “I couldn’t remember my address,” said Mr. Bunnell, 60, with a measure of horror in his voice. “I knew where I lived, and I knew how to get there, but I didn’t know what the address was.” Mr. Bunnell is among tens of millions of baby boomers who are encountering the signs, by turns amusing and disconcerting, that accompany the decline of the brain’s acuity: a good friend’s name suddenly vanishing from memory; a frantic search for eyeglasses only to find them atop the head; milk taken from the refrigerator then put away in a cupboard. “It’s probably one of the most frightening aspects of the changes we undergo as we age,” said Nancy Ceridwyn, director of educational initiatives at the American Society on Aging. “Our memories are who we are. And if we lose our memories we lose that groundedness of who we are.” At the same time, boomers are seizing on a mounting body of evidence that suggests that brains contain more plasticity than previously thought, and many people are taking matters into their own hands, doing brain fitness exercises with the same intensity with which they attack a treadmill. Copyright 2008 The New York Times Company

Keyword: Alzheimers; Learning & Memory
Link ID: 11587 - Posted: 06.24.2010

By PAULINE JELINEK and LOLITA BALDOR WASHINGTON -- Senior military officers could be talking about their emotional struggles on YouTube and MySpace this year, in a Pentagon campaign to urge troops into counseling for wartime mental problems. Defense Secretary Robert Gates announced Thursday that getting therapy "is not going to count against" troops when they apply for national security clearances. A new policy on security clearances and the idea of a planned national awareness campaign on mental illness are efforts by a Defense Department struggling to care for the many thousands of troops coming home from Iraq and Afghanistan with emotional wounds. Part of the problem is changing a military culture that equates such problems with weakness and so stigmatizes those getting treatment. "It's time for leaders of all stripes to step forward and lead by example, when it comes to mental health issues," Chairman of the Joint Chiefs of Staff Adm. Mike Mullen told a Pentagon press conference. "You can't expect a private or a specialist to be willing to seek counseling when his or her captain or colonel or general won't do it," he said. © 2008 The Associated Press

Keyword: Stress
Link ID: 11586 - Posted: 06.24.2010