By RICHARD A. FRIEDMAN, M.D. You will never guess what the fifth and sixth best-selling prescription drugs are in the United States, so I’ll just tell you: Abilify and Seroquel, two powerful antipsychotics. In 2011 alone, they and other antipsychotic drugs were prescribed to 3.1 million Americans at a cost of $18.2 billion, a 13 percent increase over the previous year, according to the market research firm IMS Health. Those drugs are used to treat such serious psychiatric disorders as schizophrenia, bipolar disorder and severe major depression. But the rates of these disorders have been stable in the adult population for years. So how did these and other antipsychotics get to be so popular? Antipsychotic drugs have been around for a long time, but until recently they were not widely used. Thorazine, the first real antipsychotic, was synthesized in the 1950s; not just sedating, it also targeted the core symptoms of schizophrenia, like hallucinations and delusions. Later, it was discovered that antipsychotic drugs also had powerful mood-stabilizing effects, so they were used to treat bipolar disorder, too. Then, starting in 1993, came the so-called atypical antipsychotic drugs like Risperdal, Zyprexa, Seroquel, Geodon and Abilify. Today there are 10 of these drugs on the market, and they have generally fewer neurological side effects than the first-generation drugs. Originally experts believed the new drugs were more effective than the older antipsychotics against such symptoms of schizophrenia as apathy, social withdrawal and cognitive deficits. But several recent large randomized studies, like the landmark Catie trial, failed to show that the new antipsychotics were any more effective or better tolerated than the older drugs. © 2012 The New York Times Company

Keyword: Schizophrenia
Link ID: 17297 - Posted: 09.25.2012

By Tori Rodriguez Feeling sociable or reckless? You might have toxoplasmosis, an infection caused by the microscopic parasite Toxoplasma gondii, which the CDC estimates has infected about 22.5 percent of Americans older than 12 years old. Researchers tested participants for T. gondii infection and had them complete a personality questionnaire. They found that both men and women infected with T. gondii were more extroverted and less conscientious than the infection-free participants. These changes are thought to result from the parasite's influence on brain chemicals, the scientists write in the May/June issue of the European Journal of Personality. “Toxoplasma manipulates the behavior of its animal host by increasing the concentration of dopamine and by changing levels of certain hormones,” says study author Jaroslav Flegr of Charles University in Prague, Czech Republic. Although humans can carry the parasite, its life cycle must play out in cats and rodents. Infected mice and rats lose their fear of cats, increasing the chance they will be eaten, so that the parasite can then reproduce in a cat's body and spread through its feces. In humans, T. gondii's effects are more subtle; the infected population has a slightly higher rate of traffic accidents, studies have shown, and people with schizophrenia have higher rates of infection—but until recent years, the parasite was not thought to affect most people's daily lives. In the new study, a pattern appeared in infected men: the longer they had been infected, the less conscientious they were. © 2012 Scientific American,

Keyword: Emotions
Link ID: 17296 - Posted: 09.25.2012

by Emily Underwood A human newborn's brain is uniquely impressionable, allowing social interactions and the environment to shape its development. But this malleability may come with a price, a new study finds. A comparison of juvenile chimpanzee and human brains suggests that differences in the development of myelin—the fatty sheath that surrounds nerve fibers—may contribute not only to our unusual adaptability, but also to our vulnerability to psychiatric diseases that start in early adulthood. Research increasingly suggests that psychiatric illnesses like depression and schizophrenia may involve problems with the timing of neural signals, says Douglas Fields, a neuroscientist at the National Institutes of Health in Bethesda, Maryland, who was not involved in the study. The nerve fibers, or axons, that connect neurons are usually protected by myelin, which enhances the neural relay of information throughout the brain. "Myelin speeds transmission of information [by] at least 50 times," Fields says, "so it matters a great deal whether or not an axon becomes myelinated." Humans start out with comparatively few myelinated axons as newborns. We experience a burst of myelin development during infancy that is followed by a long, slow growth of myelin that can last into our thirties, says Chet Sherwood, a neuroscientist at George Washington University in Washington, D.C., and a co-author of the new study. In contrast, other primates, such as macaques, start out with significantly more myelin at birth, but stop producing it by the time they reach sexual maturity. However, Sherwood says, "extraordinarily little data exists" on brain growth and the development of myelin in our closest genetic relatives, chimpanzees. © 2010 American Association for the Advancement of Science.

Keyword: Development of the Brain; Evolution
Link ID: 17295 - Posted: 09.25.2012

By Ilana Yurkiewicz It’s tough to prove gender bias. In a real-world setting, typically the most we can do is identify differences in outcome. A man is selected for hire over a woman; fewer women reach tenure track positions; there’s a gender gap in publications. Bias may be suspected in some cases, but the difficulty in using outcomes to prove it is that the differences could be due to many potential factors. We can speculate: perhaps women are less interested in the field. Perhaps women make lifestyle choices that lead them away from leadership positions. In a real-world setting, when any number of variables can contribute to an outcome, it’s essentially impossible to tease them apart and pinpoint what is causative. The only way to do that would be by a randomized controlled experiment. This means creating a situation where all variables other than the one of interest are held equal, so that differences in outcome can indeed be attributed to the one factor that differs. If it’s gender bias we are interested in, that would mean comparing reactions toward two identical human beings – identical in intelligence, competence, lifestyle, goals, etc. – with the one difference between them that one is a man and one is a woman. Not exactly a situation that exists in the real world. But in a groundbreaking study published in PNAS last week by Corinne Moss-Racusin and colleagues, that is exactly what was done. On Wednesday, Sean Carroll blogged about and brought to light the research from Yale that had scientists presented with application materials from a student applying for a lab manager position and who intended to go on to graduate school. Half the scientists were given the application with a male name attached, and half were given the exact same application with a female name attached. Results found that the “female” applicants were rated significantly lower than the “males” in competence, hireability, and whether the scientist would be willing to mentor the student. © 2012 Scientific American,

Keyword: Sexual Behavior
Link ID: 17294 - Posted: 09.25.2012

Sandrine Ceurstemont, editor, New Scientist TV Chimps may be similar to us in many ways but they can't compete when it comes to brain size. Now for the first time we can see when the differences emerge by tracking the brain development of unborn chimps. As seen in this video, Tomoko Sakai and colleagues from Kyoto University in Japan subjected a pregnant chimp to a 3D ultrasound to gather images of the fetus between 14 and 34 weeks of development. The volume of its growing brain was then compared to that of an unborn human. The team found that brain size increases in both chimps and humans until about 22 weeks, but after then only the growth of human brains continues to accelerate. This suggests that as the brain of modern humans rapidly evolved, differences between the two species emerged before birth as well as afterwards. The researchers now plan to examine how different parts of the brain develop in the womb, particularly the forebrain, which is responsible for decision-making, self-awareness and creativity. If you enjoyed this post, watch the first video MRI of unborn twins or the first MRI movie of a baby's birth. © Copyright Reed Business Information Ltd.

Keyword: Development of the Brain; Evolution
Link ID: 17293 - Posted: 09.25.2012

By DAVID K. RANDALL SOMETIME in the dark stretch of the night it happens. Perhaps it’s the chime of an incoming text message. Or your iPhone screen lights up to alert you to a new e-mail. Or you find yourself staring at the ceiling, replaying the day in your head. Next thing you know, you’re out of bed and engaged with the world, once again ignoring the often quoted fact that eight straight hours of sleep is essential. Sound familiar? You’re not alone. Thanks in part to technology and its constant pinging and chiming, roughly 41 million people in the United States — nearly a third of all working adults — get six hours or fewer of sleep a night, according to a recent report from the Centers for Disease Control and Prevention. And sleep deprivation is an affliction that crosses economic lines. About 42 percent of workers in the mining industry are sleep-deprived, while about 27 percent of financial or insurance industry workers share the same complaint. Typically, mention of our ever increasing sleeplessness is followed by calls for earlier bedtimes and a longer night’s sleep. But this directive may be part of the problem. Rather than helping us to get more rest, the tyranny of the eight-hour block reinforces a narrow conception of sleep and how we should approach it. Some of the time we spend tossing and turning may even result from misconceptions about sleep and our bodily needs: in fact neither our bodies nor our brains are built for the roughly one-third of our lives that we spend in bed. © 2012 The New York Times Company

Keyword: Sleep
Link ID: 17292 - Posted: 09.25.2012

By Susan Milius Let’s take a minute to turn faces upside down. Pick any face. Ignore beards, glasses, hairdos or lack of any hair to do, and upend the facial features of Charles Darwin, Ray Charles or anyone named Charlotte who reads Science News. People who normally remember or match a face perfectly well have trouble when it is standing on its head. But before there’s a chorus of “well, obviously,” let’s try turning dogs upside down, too. Most people who don’t breed dogs or judge shows don’t recognize an individual dog nearly as well as a person’s face to begin with. And when pictures of poodles and Irish setters flip upside down in quizzes of learning and memory, people struggle a bit more than they do with the natural versions. But scores drop only modestly with these flipped-dog pics, compared with the dramatic drop for facial flips. The disproportionate decline in remembering inverted faces has shown up in a variety of recall tests, with comparison groups from dogs to bridges, airplanes, stick figures, even clothing from 17th and 18th century paintings. Upside-down faces are where quiz scores really slump, and researchers view that slump as one of the signs that test-takers are actually experts at face perception. A dog is a dog in any orientation. Same for other organisms and objects. But right-side-up faces apparently are so compelling that people have become especially masterful at recognizing the human visage. Know-it-at-a-glance holistic techniques behind this mastery fail when the world turns upside down. access © Society for Science & the Public 2000 - 2012

Keyword: Attention; Evolution
Link ID: 17291 - Posted: 09.22.2012

by Virginia Morell Bumblebees foraging in flowers for nectar are like salesmen traveling between towns: Both seek the optimal route to minimize their travel costs. Mathematicians call this the "traveling salesman problem," in which scientists try to calculate the shortest possible route given a theoretical arrangement of cities. Bumblebees, however, take the brute-force approach: For them, it's simply a matter of experience, plus trial and error, scientists report in the current issue of PLoS Biology. The study, the first to track the movements of bumblebees in the field, also suggests that bumblebees aren't using cognitive maps—mental recreations of their environments—as some scientists have suggested, but rather are learning and remembering the distances and directions that need to be flown to find their way from nest to field to home again. A team of researchers from Queen Mary, University of London outfitted seven bumblebees with tiny radar transponders, which they stuck on the bees' backs with double-sided tape. They trained the bees to forage nectar from five blue artificial flowers (see video). Each artificial flower had a yellow landing platform and a single drop of sucrose, just enough to fill one-fifth of a bumblebee's tank capacity, to ensure that the bees would visit all five flowers on each foraging bout. The scientists placed the flowers in a field at Rothamsted Research, a biological research station north of London, in October—a time of year when there are few natural sources of nectar and pollen and the bees are more likely to focus on the artificial flowers. They arranged the flowers in a pentagon and spaced them 50 meters apart; that distance is more than three times as far as bumblebees can see, so the bees must actively fly around to locate their next target. A motion-triggered Webcam was attached to each flower to record the bees' visits. Then, every day for a month, each bee was freed to forage for 7 hours. © 2010 American Association for the Advancement of Science

Keyword: Animal Migration; Evolution
Link ID: 17290 - Posted: 09.22.2012

By Gary Stix Neuroscientists have devoted inordinate energy in recent years to publicize the need for, not only gene maps, but for a full wiring diagram of all brain circuits. The benefits of a connectome as it is known might yield new understanding that could eventually result in pharmaceuticals for intractable psychiatric disorders. This ultimate neural network might even divvy up intimations of the workings of consciousness. The futurist contingent, many of whom began careers hacking computers not neural circuity, has speculated that a whole brain blueprint of you or me might be copied to a hard drive so that we can live for a digital eternity like Max Headroom. Christof Koch, the chief scientist at the Allen Institute for Brain Science, the organization that produced the gene map, dismissed facile optimism about the prospects for these scenarios with a commentary in Science last month. In it, he calculated that it could take 2000 years to analyze all of the possible interactions among the 1,000 different proteins that populate a single synapse. Koch then went on to speculate about a way of reducing the complexity of such calculations. The question still remains of how we will know when we have actually started to make sense of the tangle of wiring that populates the deepest recesses inside our skulls. One plausible answer: when the FDA approves a new drug that fundamentally advances treatment of schizophrenia, the psychiatric illness that has aberrant effects on a multitude of neural pathways—an iconic example of the brain’s underlying complexity. © 2012 Scientific American

Keyword: Schizophrenia
Link ID: 17289 - Posted: 09.22.2012

The human brain is big and complicated. There has been a map for gene expression in mice brains available for a number of years but human brains are a thousand times bigger and a little harder to come by for post-mortem research. But published today is a high-resolution 3D atlas of the human brain created by an international team led by Michael Hawrylycz of the Allen Institute for Brain Science in Seattle. The project was launched in March 2008 with a budget of $55 million. Working with just two whole male brains and a single hemisphere from a third, the team used around 900 precise subdivisions and 60,000 gene expression probes to create the atlas. This image is a 3D rendering of just one of the genes in internal brain structures overlaid onto an MRI scan. The level of gene expression at the different points on the map is indicated on a colour scale, with blue dots reflecting relatively low expression and red dots reflecting high expression. The aim of the project is to provide a platform for further study into gene expression in the brain and how it is involved in normal and abnormal brain function. The Allen Brain Atlas is freely accessible online. Journal reference: Nature, DOI: 10.1038/nature11405 © Copyright Reed Business Information Ltd.

Keyword: Brain imaging; Genes & Behavior
Link ID: 17288 - Posted: 09.22.2012

By Janet Raloff Most people would never equate downing a well-dressed salad or a fried chicken thigh with toking a joint of marijuana. But to Joseph Hibbeln of the National Institutes of Health, the comparison isn’t a big stretch. New animal experiments by Hibbeln and his colleagues have recently shown that the body uses a major constituent in most vegetable oils to make its own versions of the psychoactive ingredient in marijuana. Called endocannabinoids, these natural compounds play a role in heightening appetite. So overproducing them unnecessarily boosts hunger, similarly to how pot triggers the munchies (SN: 6/19/10, p. 16). If what happens in people mirrors what happens in animals, then the prevalence of soybean oil, corn oil and other polyunsaturated vegetable oils in today’s Western diet means your body is “dumping out a lot of these marijuana-like molecules into your brain,” explains Hibbeln, a nutritional neuroscientist. “You’re chronically a little bit stoned.” Vegetable oil’s link to endocannabinoids is just one example of newfound and surprising ways that foods can confuse calorie-sensing networks and foster obesity — in some cases by damaging the brain. Especially troubling: Excess body weight itself can exaggerate the risk of the brain telling a well-fueled body that it is running on empty. By understanding what messes with the body’s satiety meters and why, scientists hope to identify tactics for reducing a diner’s likelihood of becoming another statistic in the obesity epidemic. © Society for Science & the Public 2000 - 2012

Keyword: Obesity; Drug Abuse
Link ID: 17287 - Posted: 09.22.2012

By RONI CARYN RABIN Amid fervid criticism that New York City risks becoming a nanny state, city health officials this month banned the sale of supersize sugar-laden drinks in restaurants and movie theaters. Now scientists have handed the ban’s advocates a potent weapon: strong evidence that replacing sugared drinks with sugar-free substitutes or water really can slow weight gain in children. Two-thirds of all American adults and one-third of children in the United States are overweight or obese. The contribution of sugary sodas and fruit drinks to this epidemic has been hotly disputed. But two new randomized clinical trials published on Friday in The New England Journal of Medicine lend credence to the idea that limiting access to these beverages may help reduce obesity. Beverage industry officials denounced the research, which may fuel wider efforts to curb consumption through taxes or other restrictions. In one of the new trials, researchers at Boston Children’s Hospital randomly assigned 224 overweight or obese teenagers to receive home deliveries of bottled water and diet drinks for one year. The children also were regularly encouraged to avoid sugary drinks. Those who received the shipments gained only 3.5 pounds on average during that year, while a comparison group of similar teenagers gained 7.7 pounds. The differences between the groups evaporated after the deliveries stopped. In the second trial, researchers at VU University Amsterdam randomly assigned 641 normal-weight schoolchildren ages 4 to 11 to drink eight ounces of a 104-calorie sugar-sweetened or noncaloric sugar-free fruit-flavored drink every day from identical cans. Over 18 months, children in the sugar-free group gained 13.9 pounds on average, while those drinking the sugar-added version gained 16.2 pounds. © 2012 The New York Times Company

Keyword: Obesity; Development of the Brain
Link ID: 17286 - Posted: 09.22.2012

By Marla Cone and Environmental Health News Children exposed to higher levels of mercury or lead are three to five times more likely to be identified by teachers as having problems associated with Attention Deficit Hyperactivity Disorder, according to a scientific study published today. The study – of Inuit children in Arctic Quebec – is the first to find a high rate of attention-deficit symptoms in children highly exposed to mercury in the womb. In addition, the Inuit children more often had hyperactivity symptoms if they were exposed to the same low levels of lead commonly found in young U.S. children. In the United States, one of every 10 children has been diagnosed with ADHD, according to the U.S. Centers for Disease Control and Prevention. It is one of the most common brain disorders of childhood. Researchers from Laval University in Quebec surveyed teachers of 279 children in Nunavik between the ages of 8 and 14, using standardized questionnaires developed by psychiatrists for diagnosing ADHD. Developmental psychologist Gina Muckle, the study’s senior author, said the findings are important because they show for the first time that mercury’s effects on children are not just subtle, but are actually noticeable to teachers. The effects from exposure in the womb “may be clinically significant and may interfere with learning and performance in the classroom,” says the study, published online in the journal Environmental Health Perspectives. . © 2012 Scientific American

Keyword: ADHD; Neurotoxins
Link ID: 17285 - Posted: 09.22.2012

By Nathan Seppa People with multiple sclerosis might soon have a new option for controlling their disease with pills instead of shots. Two studies in the Sept. 20 New England Journal of Medicine demonstrate that a variation on a drug used against psoriasis for years in Germany holds off MS relapses and has minimal side effects. “These data look good. Both studies show a reduction in relapses with really pretty robust effects,” says Clyde Markowitz, a neurologist at the University of Pennsylvania who wasn’t involved with the trials. The drug, called BG-12, has been submitted to the U.S. Food and Drug Administration for approval by the biotech company Biogen Idec. Markowitz expects it to get approved. “It would be a clear benefit to the MS population to have another option,” he says. If approved, BG-12 would be the third oral drug available to treat MS. The disease results when the immune system attacks the fatty myelin sheaths coating nerves in the central nervous system, leading to impaired muscle control, balance, vision and speech. BG-12, or dimethyl fumarate, has anti-inflammatory, cell-protective and antioxidant effects, which earlier work suggested could suppress the aberrant immune reactions in MS patients. Scientists in both studies recruited MS patients and randomly assigned some in each group to BG-12 or placebo tablets. In one of the studies, an additional group was randomly assigned to get an injectable MS drug called glatiramer acetate (Copaxone). In other respects the studies were nearly identical, each enrolling more than 1,000 MS patients, ages 18 to 55, in 28 countries apiece, for two years of treatment. Both trials included a mix of North American and European researchers. © Society for Science & the Public 2000 - 2012

Keyword: Multiple Sclerosis
Link ID: 17284 - Posted: 09.22.2012

by Douglas Heaven Ever wish you could make better choices? That could one day be possible thanks to an electronic brain implant that can enhance short-term memory and decision-making in primates. The implant can also restore these functions in an animal model of Alzheimer's disease and other types of brain damage, paving the way for the development of new treatments for people with these conditions. Sam Deadwyler at Wake Forest University School of Medicine in Winston-Salem, North Carolina, and colleagues have previously shown that a neural implant can restore some motor and sensory functions in rats. Now they have used a similar implant to stimulate higher-level thinking in monkeys. During normal brain function, neurons "fire" when they receive an input from another neuron via the connection between them, called a synapse. The spatial and temporal pattern of this activity  – where and when the neurons fire   – can be detected and recorded. To find out if it is possible to hijack and then retune these patterns of activity, Deadwyler's team first trained five rhesus macaques to perform a task that tests their attention, short-term memory and decision-making skills. First, the monkeys were shown a random image from a pool of 5000. The image was then blanked out for an interval of 1 to 90 seconds, before reappearing in a different position, alongside up to seven other images. If the monkey selected the original image once it reappeared it was rewarded with juice. © Copyright Reed Business Information Ltd.

Keyword: Attention; Learning & Memory
Link ID: 17283 - Posted: 09.22.2012

Remember the game "telephone"? Someone starts by saying a sentence to the person next to them. That person then turns to someone else and repeats what they heard. Somehow, by the time the sentence gets to the last person in line, it's all mixed up and barely resembles the original. Apparently our memories operate in the same way. A study published recently in the Journal of Neuroscience looks at how we retrieve memories. It's a well-known phenomenon that retrieval is good for memory - the more you remember something, the longer you'll remember it for. The catch, researchers have discovered, is that each time you retrieve a memory you forget or add small things to it, and the next time you recall the information, you'll remember what you remembered. "Our memories aren’t like a photograph," says lead study author Donna Bridge. "We mix up details, we forget things. We’re likely to remember this incorrect information just as much as we are the correct (memory)." In other words, the more you recall an event, the more distorted your memory of that event may be. Bridge, a postdoctoral fellow at Northwestern University's Feinberg School of Medicine, asked 12 participants to take a memory test on three subsequent days. The first day, study participants repeatedly placed 180 objects in an assigned location - different for each one - on a computer screen grid. The second day they were asked to place those objects in the same positions. Twenty-four hours later, they did it again. © 2012 Cable News Network

Keyword: Learning & Memory
Link ID: 17282 - Posted: 09.22.2012

By Mary Bates It's an oft-repeated idea that blind people can compensate for their lack of sight with enhanced hearing or other abilities. The musical talents of Stevie Wonder and Ray Charles, both blinded at an early age, are cited as examples of blindness conferring an advantage in other areas. Then there's the superhero Daredevil, who is blind but uses his heightened remaining senses to fight crime. It is commonly assumed that the improvement in the remaining senses is a result of learned behavior; in the absence of vision, blind people pay attention to auditory cues and learn how to use them more efficiently. But there is mounting evidence that people missing one sense don't just learn to use the others better. The brain adapts to the loss by giving itself a makeover. If one sense is lost, the areas of the brain normally devoted to handling that sensory information do not go unused — they get rewired and put to work processing other senses. A new study provides evidence of this rewiring in the brains of deaf people. The study, published in The Journal of Neuroscience, shows people who are born deaf use areas of the brain typically devoted to processing sound to instead process touch and vision. Perhaps more interestingly, the researchers found this neural reorganization affects how deaf individuals perceive sensory stimuli, making them susceptible to a perceptual illusion that hearing people do not experience. These new findings are part of the growing research on neuroplasticity, the ability of our brains to change with experience. A large body of evidence shows when the brain is deprived of input in one sensory modality, it is capable of reorganizing itself to support and augment other senses, a phenomenon known as cross-modal neuroplasticity. © 2012 Scientific American

Keyword: Vision; Hearing
Link ID: 17281 - Posted: 09.19.2012

Children and teens with higher levels of BPA, a chemical used in canned foods, are more likely to be overweight and obese but whether the chemical caused the weight gain can’t be answered. The issue of obesity is addressed in Tuesday's online edition of the Journal of the American Medical Association. In one U.S. study, researchers wanted to test the idea that hormone-like chemicals like bisphenol A, also called BPA, could be contributing to childhood obesity by disrupting kids' metabolism. BPA is used to make hard plastics for food and beverage containers. It also found in the lining of many metal cans. Dr. Leonardo Trasande of the New York University School of Medicine and his co-authors looked at BPA concentrations in the urine of 2,838 Americans aged six to 19 as well as body mass index scores. "Urinary BPA concentrations was significantly associated with obesity in this cross-sectional study of children and adolescents," the study's authors concluded. The researchers weren't able to tell which came first, the obesity or BPA concentrations. © CBC 2012

Keyword: Obesity; Neurotoxins
Link ID: 17280 - Posted: 09.19.2012

Some people who are severely obese and have gastric bypass surgery may be able to keep weight off for six years, giving them reduced risks of cardiovascular problems and diabetes, a U.S. study finds. The study focused on 1,156 adults with a body mass index of 35 or higher — which is considered severely obese — and who had the bypass surgery. They were compared with 739 other severely obese people in two groups who did not get the surgery. "At six years, 96 per cent of surgical patients had maintained more than 10 per cent weight loss from baseline and 76 per cent had maintained more than 20 per cent weight loss," Ted Adams of the University of Utah School of Medicine and his co-authors wrote in Tuesday’s issue of the Journal of the American Medical Association. All cardiovascular risk factors improved or stayed the same among those who received a type of gastric bypass surgery called Roux-en-Y compared with those who did not, Adams said. Other differences at the end of the study included: Mortality rate three per cent for surgery patients, three per cent for obese patients who were evaluated and one per cent among the control group of obese adults. Diabetes remission 62 per cent for surgery, eight per cent in control group 1 and six per cent in control group 2. © CBC 2012

Keyword: Obesity
Link ID: 17279 - Posted: 09.19.2012

By GRETCHEN REYNOLDS Most people who start working out in hopes of shedding pounds wind up disappointed, a lamentable circumstance familiar to both exercisers and scientists. Multiple studies, many of them covered in this column, have found that without major changes to diet, exercise typically results in only modest weight loss at best (although it generally makes people much healthier). Quite a few exercisers lose no weight. Some gain. But there is encouraging news about physical activity and weight loss in a new study by researchers at the University of Copenhagen. It found that exercise does seem to contribute to waist-tightening, provided that the amount of exercise is neither too little nor, more strikingly, too much. To reach that conclusion, the Danish scientists rounded up a group of pudgy and sedentary young men, a segment of the population increasingly common in Denmark, as elsewhere in the world. The volunteers, most in their 20s or early 30s, visited the scientists’ lab to undergo baseline measurements of their aerobic fitness, body fat, metabolic rates and general health. None had diabetes, high blood pressure or heart disease and, while heavy, they were not obese. The men were then randomly assigned to exercise or not. The non-exercisers, who served as controls, returned to their former routines, with no change to their diets or sedentary ways. A second group began 13 weeks of almost daily moderate workouts, consisting of jogging, cycling or otherwise sweating for about 30 minutes, or until each man had burned 300 calories (based on his individual metabolic rate). Copyright 2012 The New York Times Company

Keyword: Obesity
Link ID: 17278 - Posted: 09.19.2012