By GRETCHEN REYNOLDS Obesity may have harmful effects on the brain, and exercise may counteract many of those negative effects, according to sophisticated new neurological experiments with mice, even when the animals do not lose much weight. While it’s impossible to know if human brains respond in precisely the same way to fat and physical activity, the findings offer one more reason to get out and exercise. It’s been known for some time that obesity can alter cognition in animals. Past experiments with lab rodents, for instance, have shown that obese animals display poor memory and learning skills compared to their normal-weight peers. They don’t recognize familiar objects or recall the location of the exit in mazes that they’ve negotiated multiple times. But scientists hadn’t understood how excess weight affects the brain. Fat cells, they knew, manufacture and release substances into the bloodstream that flow to other parts of the body, including the heart and muscles. There, these substances jump-start biochemical processes that produce severe inflammation and other conditions that can lead to poor health. Many thought the brain, though, should be insulated from those harmful effects. It contains no fat cells and sits behind the protective blood-brain barrier that usually blocks the entry of undesirable molecules. However, recent disquieting studies in animals indicate that obesity weakens that barrier, leaving it leaky and permeable. In obese animals, substances released by fat cells can ooze past the barrier and into the brain. The consequences of that seepage became the subject of new neurological experiments conducted by researchers at Georgia Regents University in Augusta and published last month in The Journal of Neuroscience. © 2014 The New York Times Company

Keyword: Obesity
Link ID: 19323 - Posted: 03.05.2014

By BENEDICT CAREY He heard about the drug trial from a friend in Switzerland and decided it was worth volunteering, even if it meant long, painful train journeys from his native Austria and the real possibility of a mental meltdown. He didn’t have much time, after all, and traditional medicine had done nothing to relieve his degenerative spine condition. “I’d never taken the drug before, so I was feeling — well, I think the proper word for it, in English, is dread,” said Peter, 50, an Austrian social worker, in a telephone interview; he asked that his last name be omitted to protect his identity. “There was this fear that it could all go wrong, that it could turn into a bad trip.” On Tuesday, The Journal of Nervous and Mental Disease is posting online results from the first controlled trial of LSD in more than 40 years. The study, conducted in the office of a Swiss psychiatrist near Bern, tested the effects of the drug as a complement to talk therapy for 12 people nearing the end of life, including Peter. Most of the subjects had terminal cancer, and several died within a year after the trial — but not before having a mental adventure that appeared to have eased the existential gloom of their last days. “Their anxiety went down and stayed down,” said Dr. Peter Gasser, who conducted the therapy and followed up with his patients a year after the trial concluded. The new publication marks the latest in a series of baby steps by a loose coalition of researchers and fund-raisers who are working to bring hallucinogens back into the fold of mainstream psychiatry. Before research was banned in 1966 in the United States, doctors tested LSD’s effect for a variety of conditions, including end-of-life anxiety. But in the past few years, psychiatrists in the United States and abroad — working with state regulators as well as ethics boards — have tested Ecstasy-assisted therapy for post-traumatic stress; and other trials with hallucinogens are in the works. © 2014 The New York Times Company

Keyword: Depression; Drug Abuse
Link ID: 19322 - Posted: 03.04.2014

|By Roni Jacobson Modern antipsychotic drugs are increasingly prescribed to children and adolescents diagnosed with a broad variety of ailments. The drugs help to alleviate symptoms in some disorders, such as schizophrenia and bipolar disorder, but in others their effectiveness is questionable. Yet off-label prescribing is on the rise, especially in children receiving public assistance and Medicaid. Psychotic disorders typically arise in adulthood and affect only a small proportion of children and adolescents. Off-label prescriptions, however, most often target aggressive and disruptive behaviors associated with attention-deficit hyperactivity disorder (ADHD). “What's really concerning now is that a lot of this prescription is occurring in the face of emerging evidence that there are significant adverse effects that may be worse in youth than in adults,” says David Rubin, a general pediatrician and co-director of PolicyLab at Children's Hospital of Philadelphia. Here we review the evidence for the effectiveness of antipsychotic medications commonly prescribed for five childhood conditions. But do the benefits outweigh the risks? Schizophrenia Evidence from several randomized controlled trials conducted in the past 10 years strongly suggests that antipsychotics are an effective treatment for youths with schizophrenia. Indeed, the FDA has approved five medications—risperidone, aripiprazole, olanzapine, quetiapine and paliperidone—for use in adolescents aged 13 to 17. Bipolar Disorder Recent research indicates that antipsychotics may hasten the resolution of manic and mixed episodes in children with bipolar disorder and increase the likelihood that the illness will go into remission. The FDA has approved the same set of drugs for 10- to 17-year-olds with bipolar disorder as it has for youths with schizophrenia, with the exception of paliperidone. © 2014 Scientific American

Keyword: Development of the Brain; Schizophrenia
Link ID: 19321 - Posted: 03.04.2014

The teenager's brain has a lot of developing to do: It must transform from the brain of a child into the brain of an adult. Some researchers worry how marijuana might affect that crucial process. "Actually, in childhood our brain is larger," says , director of the brain imaging and neuropsychology lab at University of Wisconsin, Milwaukee. "Then, during the teenage years, our brain is getting rid of those connections that weren't really used, and it prunes back. "It actually makes the brain faster and more efficient." The streamlining process ultimately helps the brain make judgments, think critically and remember what it has learned. Lisdahl says it's a mistake for teenagers to use cannabis. "It's the absolute worst time," she says, because the mind-altering drug can disrupt development. Think of the teen years, she says, as the "last golden opportunity to make the brain as healthy and smart as possible." Lisdahl points to a growing number of that show regular marijuana use — once a week or more — actually changes the structure of the teenage brain, specifically in areas dealing with memory and problem solving. That can affect cognition and academic performance, she says. "And, indeed, we see, if we look at actual grades, that chronic marijuana-using teens do have, on average, one grade point lower than their matched peers that don't smoke pot," Lisdahl says. ©2014 NPR

Keyword: Drug Abuse; Development of the Brain
Link ID: 19320 - Posted: 03.04.2014

by Tom Siegfried Max Planck, who shook the world with his discovery of quantum physics, also offered a warning. “One must be careful,” he said, “when using the word, real.” It was good advice. As physicists explored the quantum domain, they found that usual ideas about reality did not apply. Reality in the realm of atoms was nothing like the world of rocks and baseballs and planets, where Newton’s laws of motions ruled with rigor. Among atoms, the rules were more like Olympic ice skating judging, with unpredictable scores. Gradually physicists, engineers and even screenwriters became familiar with quantum weirdness and used it in lasers, computers and movie plots. Quantum reality might be crazy, but it’s our reality, and most scientists, anyway, have become more or less used to it. Nevertheless, Planck’s warning still applies. Perhaps the quantum picture of reality is another illusion, just like Newton’s was. Human insight into nature may not yet have penetrated reality’s ultimate veil. In other words, maybe reality always dresses itself up in Newtonian or Einsteinian or quantum clothing, and science hasn’t yet seen what reality looks like naked. And that might explain why nature has been able to protect so many of its mysteries from science’s prying eyes — mysteries like the identity of dark matter, the math describing quantum gravity, the mechanism underlying consciousness. And whether humans have free will. Maybe reality always dresses itself up in Newtonian or Einsteinian or quantum clothing, and science hasn’t yet seen what reality looks like naked. © Society for Science & the Public 2000 - 2013.

Keyword: Consciousness
Link ID: 19319 - Posted: 03.04.2014

By Deborah Kotz Glaring gaps persist in medical researchers’ efforts to understand gender differences in common diseases, two decades after the passage of pivotal legislation mandating that more women be included in government-funded clinical trials, concludes a report being released Monday at a women’s health summit in Boston. The authors said research still lags on understanding how treatments for heart disease—the number one killer of women—affect the sexes differently, because women make up only one-third of the participants in clinical trials to test new drugs and medical devices, and most of these studies don’t report results for men and women separately. Women who don’t smoke are, for unknown reasons, three times more likely than non-smoking men to get lung cancer, but they’re still less likely than men to enroll in lung cancer studies, notes the report from Brigham and Women’s Hospital. And twice as many women suffer from depression as men, but fewer than 45 percent of animal studies to better understand anxiety and depression use female lab animals. “Women are now routinely included in clinical trials, but we are far from achieving equity in biomedical research,” said report leader Dr. Paula Johnson, executive director of the Brigham’s Connors Center for Women’s Health and Gender Biology. To address research disparities, the authors recommended that government agencies, drug manufacturers, hospital review boards that approve studies, and medical journal editors institute substantial changes to make women’s health a research priority. © 2014 Boston Globe Media Partners, LLC

Keyword: Sexual Behavior
Link ID: 19318 - Posted: 03.04.2014

By ANDREW POLLACK In the late 1980s, scientists at Osaka University in Japan noticed unusual repeated DNA sequences next to a gene they were studying in a common bacterium. They mentioned them in the final paragraph of a paper: “The biological significance of these sequences is not known.” Now their significance is known, and it has set off a scientific frenzy. The sequences, it turns out, are part of a sophisticated immune system that bacteria use to fight viruses. And that system, whose very existence was unknown until about seven years ago, may provide scientists with unprecedented power to rewrite the code of life. In the past year or so, researchers have discovered that the bacterial system can be harnessed to make precise changes to the DNA of humans, as well as other animals and plants. This means a genome can be edited, much as a writer might change words or fix spelling errors. It allows “customizing the genome of any cell or any species at will,” said Charles Gersbach, an assistant professor of biomedical engineering at Duke University. Already the molecular system, known as Crispr, is being used to make genetically engineered laboratory animals more easily than could be done before, with changes in multiple genes. Scientists in China recently made monkeys with changes in two genes. Scientists hope Crispr might also be used for genomic surgery, as it were, to correct errant genes that cause disease. Working in a laboratory — not, as yet, in actual humans — researchers at the Hubrecht Institute in the Netherlands showed they could fix a mutation that causes cystic fibrosis. But even as it is stirring excitement, Crispr is raising profound questions. Like other technologies that once wowed scientists — like gene therapy, stem cells and RNA interference — it will undoubtedly encounter setbacks before it can be used to help patients. © 2014 The New York Times Company

Keyword: Genes & Behavior
Link ID: 19317 - Posted: 03.04.2014

By LISA FELDMAN BARRETT CAN you detect someone’s emotional state just by looking at his face? It sure seems like it. In everyday life, you can often “read” what someone is feeling with the quickest of glances. Hundreds of scientific studies support the idea that the face is a kind of emotional beacon, clearly and universally signaling the full array of human sentiments, from fear and anger to joy and surprise. Increasingly, companies like Apple and government agencies like the Transportation Security Administration are banking on this transparency, developing software to identify consumers’ moods or training programs to gauge the intent of airline passengers. The same assumption is at work in the field of mental health, where illnesses like autism and schizophrenia are often treated in part by training patients to distinguish emotions by facial expression. But this assumption is wrong. Several recent and forthcoming research papers from the Interdisciplinary Affective Science Laboratory, which I direct, suggest that human facial expressions, viewed on their own, are not universally understood. The pioneering work in the field of “emotion recognition” was conducted in the 1960s by a team of scientists led by the psychologist Paul Ekman. Research subjects were asked to look at photographs of facial expressions (smiling, scowling and so on) and match them to a limited set of emotion words (happiness, anger and so on) or to stories with phrases like “Her husband recently died.” Most subjects, even those from faraway cultures with little contact with Western civilization, were extremely good at this task, successfully matching the photos most of the time. Over the following decades, this method of studying emotion recognition has been replicated by other scientists hundreds of times. In recent years, however, at my laboratory we began to worry that this research method was flawed. In particular, we suspected that by providing subjects with a preselected set of emotion words, these experiments had inadvertently “primed” the subjects — in effect, hinting at the answers — and thus skewed the results. © 2014 The New York Times Company

Keyword: Emotions
Link ID: 19316 - Posted: 03.03.2014

by Laura Sanders It truly pains me to bring you tired parents another round of “Is this bad for my baby?” But this week, a new study suggests that some white noise machines designed for babies can produce harmful amounts of sound. Before you despair about trashing your baby’s hearing, please keep in mind that like any study, the results are limited in what they can actually claim. And this one is no exception. I learned the power of white noise when Baby V and I ventured out to meet some new mamas for lunch. As I frantically tried to reverse the ensuing meltdown, another mom came over with her phone. “Try this,” she said as she held up her phone and blasted white noise. Lo and behold, her black magic worked. Instantly, Baby V snapped to attention, stopped screaming and stared wide-eyed at the dark wizardry that is the White Noise Lite app. Since then, I learned that when all else failed, the oscillating fan setting could occasionally jolt Baby V out of a screamfest. In general, I didn’t leave the noise on for long. It was annoying, and more importantly, it stopped working after the novelty wore off. But lots of parents do rely on white noise to soothe their babies and help them sleep through the night. These machines are recommended on top parenting websites by top pediatricians, parenting bloggers and, most convincingly, all of the other parents you know. Use liberally, the Internet experts recommend. To reap the benefits, white noise machines should be played all night long for at least the entire first year, many people think. And don’t be shy: The noise should be louder than you think. © Society for Science & the Public 2000 - 2013

Keyword: Hearing; Development of the Brain
Link ID: 19315 - Posted: 03.03.2014

By Ariana Eunjung Cha, Standing in a Wisconsin State Capitol hearing room surrounded by parents hugging their seriously ill children, Sally Schaeffer began to cry as she talked about her daughter. Born with a rare chromosomal disorder, 6-year-old Lydia suffers from life-threatening seizures that doctors haven’t been able to control despite countless medications. The family’s last hope: medical marijuana. Schaeffer, 39, didn’t just ask lawmakers to legalize the drug. She begged. “If it was your child and you didn’t have options, what would you do?” she said during her testimony in Madison on Feb. 12. The representatives were so moved that they introduced a bipartisan bill to allow parents in situations similar to Schaeffer’s to use the drug on their children. Emboldened by stories circulated through Facebook, Twitter and the news media about children with seizure disorders who have been successfully treated with a special oil extract made from cannabis plants, mothers have become the new face of the medical marijuana movement. Similar scenes have been playing out in recent weeks in other states where medical marijuana remains illegal: Oklahoma, Florida, Georgia, Utah, New York, North Carolina, Alabama, Kentucky. The “mommy lobby” has been successful at opening the doors to legalizing marijuana — if only a crack, in some places — where others have failed. In the 1970s and ’80s, mothers were on the other side of the issue, successfully fending off efforts to decriminalize marijuana with heartbreaking stories about how their teenage children’s lives unraveled when they began to use the drug. © 1996-2014 The Washington Post

Keyword: Drug Abuse; Epilepsy
Link ID: 19314 - Posted: 03.03.2014

by Megan Gannon, Live Science News Editor Never before seen in biology, a state of matter called "disordered hyperuniformity" has been discovered in the eye of a chicken. This arrangement of particles appears disorganized over small distances but has a hidden order that allows material to behave like both a crystal and a liquid. The discovery came as researchers were studying cones, tiny light-sensitive cells that allow for the perception of color, in the eyes of chickens. For chickens and other birds that are most active during the daytime, these photoreceptors come in four different color varieties — violet, blue, green and red — and a fifth type for detecting light levels, researchers say. Each type of cone is a different size. These cells are crammed into a single tissue layer on the retina. Many animals have cones arranged in an obvious pattern. Insect cones, for example, are laid out in a hexagonal scheme. The cones in chicken eyes, meanwhile, appear to be in disarray. But researchers who created a computer model to mimic the arrangement of chicken cones discovered a surprisingly tidy configuration. Around each cone is a so-called exclusion region that bars other cones of the same variety from getting too close. This means each cone type has its own uniform arrangement, but the five different patterns of the five different cone types are layered on top of each other in a disorderly way, the researchers say. © 2014 Discovery Communications, LLC.

Keyword: Vision; Development of the Brain
Link ID: 19313 - Posted: 03.03.2014

|By Christie Nicholson Our memories are inaccurate, more than we’d like to believe. And now a study demonstrates one reason: we apparently add current experiences onto memories. Study subjects examined the location of objects on a computer screen against a background of an underwater ocean scene. Researchers then showed the subjects a fresh screen with a different background, this time a photo of farmland. And the subjects had to place an object in the same position it was in on the original screen. And they always placed the object in the wrong position. The researchers then presented three objects on the original ocean background. One was in the original location, another was in the location the subject just chose in the previous task and the third was in a new location. The subject was asked to pick the original location of the object in the original ocean background. And instead of choosing the original correct location, they always picked the position they had chosen. That is, they now believed the position they’d picked on the farm scene was the original position on the ocean background. The study is in the Journal of Neuroscience. [Donna J. Bridge and Joel L. Voss, Hippocampal Binding of Novel Information with Dominant Memory Traces Can Support Both Memory Stability and Change] The researchers note that recent and easily retrievable information “can overwrite what was there to begin with.” Consider that next time you hear eyewitness testimony. © 2014 Scientific American

Keyword: Learning & Memory
Link ID: 19312 - Posted: 03.03.2014

by Clare Wilson More genetic mutations may be needed to give rise to autism in girls than in boys. The finding supports the notion that the female brain is somehow protected against autism, and this may in turn explain why four times as many males have autism than females. Although some cases of autism are associated with one mutation, most are thought to involve several genetic abnormalities. In the past few years, hundreds of mutations have been discovered that can make people more vulnerable to the condition. To see if the mutations affect men and women differently, Sébastien Jacquemont at the University Hospital of Lausanne in Switzerland and colleagues measured the frequency of two different kinds of mutation in 762 families that had a child with autism. Among the children with autism, one class of mutation known as a copy number variation – deletions or duplications of a large chunk of genetic material – was three times more common in girls than in boys. The team also found that substitutions of a single letter of DNA were about one-third more common in affected girls. Jacquemont says this suggests it takes more mutations for autism to arise in girls than in boys. "Females function a lot better than males with similar mutations," he says. The results reflect the "shielding" effect of being female, he says. "There's something that's protecting [their] brain development." A larger, as yet unpublished, study of about 2400 people with autism, conducted as part of the Autism Genome Project - an attempt to sequence the whole genome of 10,000 individuals affected by the condition – has produced similar results, says Joseph Buxbaum of Mount Sinai Hospital in New York. © Copyright Reed Business Information Ltd.

Keyword: Autism; Genes & Behavior
Link ID: 19311 - Posted: 03.01.2014

Sara Reardon A flipped mental switch is all it takes to make a fly fall in love — even if its object of desire is a ball of wax. A technique called thermogenetics allows researchers to control fly behaviour by activating specific neurons with heat. Combining the system with techniques that use light to trigger neurons could help to elucidate how different neural circuits work together to control complex behaviours such as courtship. Optogenetics — triggering neurons with light — has been successful in mice but has not been pursued much in flies, says Barry Dickson, a neuroscientist at the Howard Hughes Medical Institute's Janelia Farm Research Campus in Ashburn, Virginia. A fibre-optic cable embedded in a mouse’s brain can deliver light to cells genetically engineered to make light-activated proteins, but flies are too small for these fibre optics. Neither will these cells be activated when the flies are put into an illuminated box, because most wavelengths of visible light cannot penetrate a fly’s exoskeleton. Heat can penetrate the exoskeleton, however. Researchers have already studied fly behaviour by adding a heat-activated protein called TRPA1 to neural circuits that control behaviours such as mating and decision-making. When these flies are placed in a hot box, the TRPA1 neurons begin to fire within minutes and drive the fly’s actions1. But it would be better to trigger the behaviours more quickly. So Dickson’s lab has developed a system called the Fly Mind-Altering Device (FlyMAD), which uses a video camera to track the fly as it moves around in a box. The device then shines an infrared laser at the fly to deliver heat directly to the head. Dickson’s group presented the system last October at the Neurobiology of Drosophila conference at Cold Spring Harbor Laboratory in New York, and he is now submitting the work to a peer-reviewed journal. © 2014 Nature Publishing Group

Keyword: Sexual Behavior; Brain imaging
Link ID: 19310 - Posted: 03.01.2014

Carl Zimmer Forcing male flies into monogamy has a startling effect: After a few dozen generations, the flies become worse at learning. This discovery, published on Wednesday in the Proceedings of the Royal Society, isn’t a biological excuse for men who have strayed from their significant other. Instead, it’s a tantalizing clue about why intelligence evolved. The new study was carried out by Brian Hollis and Tadeusz J. Kawecki, biologists at the University of Lausanne in Switzerland. They investigated a fly species called Drosophila melanogaster that normally has a very un-monogamous way of life. To find a mate, the male flies seek out females on rotting pieces of fruit. They often engage in battles to chase their rivals away, and then pick a female to court. “The males will do this wing song, where they use one wing or the other to generate a song,” said Dr. Hollis. This wing song may last from 10 minutes to an hour. Virgin females usually accept the overtures. But if a female has just mated, she will reject a new male’s advances. “If a male comes at her from behind and she’s not interested, she’ll kick at him with her rear legs,” said Dr. Hollis. If a couple of days have passed since her last mating, however, the female may choose to mate again. Seven years ago, while he was a graduate student at Florida State University, Dr. Hollis set out to study how the competition among males shapes their evolution. He began breeding two groups of flies — one polygamous, the other monogamous. In 2011, he took his flies to the University of Lausanne, where he met Dr. Kawecki, an expert on learning. The two scientists wondered if the different mating habits of Dr. Hollis’s flies had altered their brains. © 2014 The New York Times Company

Keyword: Sexual Behavior; Intelligence
Link ID: 19309 - Posted: 03.01.2014

Brian Owens The distinctive aroma of goats does more than just make barnyards extra fragrant. Male goats can use their heady scent to make female goats ovulate simply by being near them. Researchers had ascribed this 'male effect' to chemicals known as primer pheromones — a chemical signal that can cause long-lasting physiological responses in the recipient. Examples of primer pheromones are rare in mammals; the male effect in goats and sheep, and a similar effect in mice and rats, where the presence of males can speed up puberty in females, are the only known cases. But exactly what substances are at work and how has remained a mystery. Now, reproductive biologist Yukari Takeuchi from the University of Tokyo and her colleagues have identified a single molecule, known as 4-ethyloctanal, in the cocktail of male goat pheromones that activates the neural pathway that regulates reproduction in females1. ”It has long been thought that pheromones have pivotal roles in reproductive success in mammals, but the mechanisms are scarcely known,” says Takeuchi. The researchers found that male goat pheromones are generally synthesized in the animal's head skin, so they designed a hat containing a material that captured their odorous molecules and placed them on the goats for a week to collect the scent. Analysis of the gases collected identified a range of compounds, many of which were unknown and were not present in castrated males. When exposed to a cocktail of 18 of these chemicals, the brains of female goats showed a sudden increase in the activity of the gonadotropin-releasing hormone (GnRH) pulse generator — the neural regulator of reproduction. © 2014 Nature Publishing Group,

Keyword: Chemical Senses (Smell & Taste); Sexual Behavior
Link ID: 19308 - Posted: 03.01.2014

A brain-training video game that improved the vision of college baseball players by as much as two lines on an eye chart has been developed by U.S. researchers. "This is something which I think could help almost anybody," said Aaron Seitz, a neuroscientist at the University of California, Riverside, who the led the research. Players on the university's baseball team improved their visual acuity by 31 per cent after training with the app. And that translated into better performance on the baseball field, where better vision improves the odds of hitting a ball travelling well over 100 km/h. "What we found is they had fewer strikeouts, they were able to create more runs," Seitz told CBC's Quirks & Quarks in an interview that airs Saturday. The players had more runs than predicted even after taking into account the natural improvement that would be expected over the course of the season. Further calculations suggest the improved performance helped the team to win four or five additional games. Following 30 sessions of training with the app, players had better vision, fewer strikeouts, more runs and more wins. But Seitz thinks the app has even more potential to help people with eye conditions such as lazy eye, glaucoma, or age-related macular degeneration. There are 100 million people around the world who have such low vision that glasses don't help, he added. "All that they have to gain is the brain training element.… For these people, there's just really big real-world benefits that could be achieved if we're able to improve their vision."

Keyword: Vision; Learning & Memory
Link ID: 19307 - Posted: 03.01.2014

Brendan Borrell Scientists can now take snapshots of where and how thousands of genes are expressed in intact tissue samples, ranging from a slice of a human brain to the embryo of a fly. The technique, reported today in Science1, can turn a microscope slide into a tool for creating data-rich, three-dimensional maps of how cells interact with one another — a key to understanding the origins of diseases such as cancer. The methodology also has broader applications, enabling researchers to create, for instance, unique molecular ‘barcodes’ to trace connections between cells in the brain, a stated goal of the US National Institutes of Health's Human Connectome Project. Previously, molecular biologists had a limited spatial view of gene expression, the process by which a stretch of double-stranded DNA is turned into single-stranded RNAs, which can in turn be translated into protein products. Researchers could either grind up a hunk of tissue and catalogue all the RNAs they found there, or use fluorescent markers to track the expression of up to 30 RNAs inside each cell of a tissue sample. The latest technique maps up to thousands of RNAs. Mapping the matrix In a proof-of-principle study, molecular biologist George Church of Harvard Medical School in Boston, Massachusetts, and his colleagues scratched a layer of cultured connective-tissue cells and sequenced the RNA of cells that migrated to the wound during the healing process. Out of 6,880 genes sequenced, the researchers identified 12 that showed changes in gene expression, including eight that were known to be involved in cell migration but had not been studied in wound healing, the researchers say. “This verifies that the technique could be used to do rapidly what has taken scientists years of looking at gene products one by one,” says Robert Singer, a molecular cell biologist at Albert Einstein College of Medicine in New York, who was not involved in the study. © 2014 Nature Publishing Group,

Keyword: Genes & Behavior; Brain imaging
Link ID: 19306 - Posted: 03.01.2014

Linda Carroll TODAY contributor Insomnia isn’t something that just happens at night. Researchers have now shown that insomniacs have more active brains than sound sleepers, according to a report published Friday in the journal Sleep. That means sleeplessness may, in fact, have its roots in brain wiring that affects the way our minds work, no matter what time of day it is. “We see insomnia now as more of a 24/7 disorder,” said Dr. Rachel Salas, an assistant professor of neurology at the Johns Hopkins University School of Medicine and lead author of the new study. “It’s like a light switch is continually on. So their brains are always running.” Salas originally thought that sound sleepers would be the ones with more alert and plastic brains. (Brain plasticity basically means how neural pathways can be modified by experience or that it is able to adapt or grow.) To prove the theory, Salas set up an experiment that compared 18 chronic insomniacs to 10 sound sleepers. All of the study volunteers were hooked up to a device that sends magnetic waves through the skull and into the brain. Because transcranial magnetic stimulation (TMS) can be aimed a specific site, the researchers were able to target a point in the motor cortex that controls movements of the thumb. Each magnetic pulse sparked an involuntary twitching of the digit. After 65 run-throughs with the TMS, study volunteers were asked to practice moving their thumbs on their own in a manner opposite to the one that was sparked by the TMS. So, for example, if the TMS sent volunteers’ thumbs flicking up and left, they would be asked to wiggle their digits down and right.

Keyword: Sleep
Link ID: 19305 - Posted: 03.01.2014

By STEPHEN P. HINSHAW and RICHARD M. SCHEFFLER BERKELEY, Calif. — THE writing is on the chalkboard. Over the next few years, America can count on a major expansion of early childhood education. We embrace this trend, but as health policy researchers, we want to raise a major caveat: Unless we’re careful, today’s preschool bandwagon could lead straight to an epidemic of 4- and 5-year-olds wrongfully being told that they have attention deficit hyperactivity disorder. Introducing millions of 3- to 5-year-olds to classrooms and preacademic demands means that many more distracted kids will undoubtedly catch the attention of their teachers. Sure, many children this age are already in preschool, but making the movement universal and embedding transitional-K programs in public schools is bound to increase the pressure. We’re all for high standards, but danger lurks. The American Academy of Pediatrics now endorses the idea that the diagnosis of A.D.H.D. can and should begin at age 4, before problems accumulate. In fact, Adderall and other stimulants are approved for treatment of attentional issues in children as young as 3. Early intervention for children with A.D.H.D. could provide great relief. Children who go untreated have major difficulties in school and with their peers, and they have higher-than-normal rates of accidents and physical injuries. The problem is that millions of American children have been labeled with A.D.H.D. when they don’t truly have it. Our research has revealed a worrisome parallel between our nation’s increasing push for academic achievement and increased school accountability — and skyrocketing A.D.H.D. diagnoses, particularly for the nation’s poorest children. © 2014 The New York Times Company

Keyword: ADHD; Development of the Brain
Link ID: 19304 - Posted: 02.27.2014