By Liz Tormes When I first started working as a photo researcher for Scientific American MIND in 2013, a large part of my day was spent looking at brains. Lots of them. They appeared on my computer screen in various forms—from black-and-white CT scans featured in dense journals to sad-looking, grey brains sitting on the bottom of glass laboratory jars. At times they were boring, and often they could be downright disturbing. But every now and then I would come across a beautiful 3D image of strange, rainbow-colored pathways in various formations that looked like nothing I had ever seen before. I was sure it had been miscategorized somehow—no way was I looking at a brain! Through my work I have encountered countless images of multi-colored Brainbows, prismatic Diffusion Tensor Imaging (DTI), and even tiny and intricate neon mini-brains grown from actual stem cells in labs. Increasingly I have found myself dazzled, not just by the pictures themselves, but by the scientific and technological advances that have made this type of imaging possible in only the past few years. It was through my photo research that I happened upon the Netherlands Institute for Neuroscience’s (NIN) annual Art of Neuroscience contest. This exciting opportunity for neurologists, fine artists, videographers and illustrators, whose work is inspired by human and animal brains, was something I wanted to share with our readers. © 2018 Scientific American

Keyword: Brain imaging
Link ID: 24803 - Posted: 03.31.2018

By Simon Makin Neuroscientists today know a lot about how individual neurons operate but remarkably little about how large numbers of them work together to produce thoughts, feelings and behavior. What is needed is a wiring diagram for the brain—known as a connectome—to identify the circuits that underlie brain functions. The challenge is dizzying: There are around 100 billion neurons in the human brain, which can each make thousands of connections, or synapses, making potentially hundreds of trillions of connections. So far, researchers have typically used microscopes to visualize neural connections, but this is laborious and expensive work. Now in a paper published March 28 in Nature, an innovative brain-mapping technique developed at Cold Spring Harbor Laboratory (CSHL) has been used to trace the connections emanating from hundreds of neurons in the main visual area of the mouse cortex, the brain’s outer layer. The technique, which exploits the advancing speed and plummeting cost of genetic sequencing, is more efficient than current methods, allowing the team to produce a more detailed picture than previously possible at unprecedented speed. Once the technology matures it could be used to provide clues to the nature of neuro-developmental disorders such as autism that are thought to involve differences in brain wiring. The team, led by Anthony Zador at CSHL and neuroscientist Thomas Mrsic-Flogel of the University of Basel in Switzerland, verified their method by comparing it with a previous gold-standard means of identifying connections among nerve cells—a technique called fluorescent single neuron tracing. This involves introducing into cells genes that produce proteins that fluoresce with a greenish glow, so they and their axons (neurons’ output wires) can be visualized with light microscopy. © 2018 Scientific American

Keyword: Brain imaging; Schizophrenia
Link ID: 24802 - Posted: 03.30.2018

A new report says an estimated one in every 66 Canadian children and youth aged five to 17 has autism spectrum disorder. The report by the Public Health Agency of Canada, released on Thursday, is the first detailing the national prevalence of the neurodevelopmental disorder and is in line with estimates in the United States. Autism spectrum disorder is typically detected in early childhood and causes impairments in communication skills and social interactions, often combined with repetitive behaviours and restricted interests or activities. Boys are four to five times more likely to be diagnosed with autism spectrum disorder, or ASD, than girls. "Understanding trends and patterns in ASD diagnosis is essential to developing meaningful programs and services to support people living with ASD and their families," said Dr. Theresa Tam, chief public health officer, noting that the estimates establish a baseline that will help researchers determine if prevalence rates are changing over time. The report includes data from six provinces and one territory and found prevalence ranged from a high of one in 57 children in Newfoundland and Labrador, to one in 126 in Yukon. Newfoundland and Labrador, Nova Scotia, Prince Edward Island, New Brunswick, Quebec, British Columbia and Yukon all contributed data to the report, a spokesperson for the Public Health Agency of Canada said. ©2018 CBC/Radio-Canada.

Keyword: Autism
Link ID: 24801 - Posted: 03.30.2018

Rachel Ehrenberg BOSTON — Getting your groove on solo with headphones on might be your jam, but it can’t compare with a live concert. Just ask your brain. When people watch live music together, their brains waves synchronize, and this brain bonding is linked with having a better time. The new findings, reported March 27 at a Cognitive Neuroscience Society meeting, are a reminder that humans are social creatures. In western cultures, performing music is generally reserved for the tunefully talented, but this hasn’t been true through much of human history. “Music is typically linked with ritual and in most cultures is associated with dance,” said neuroscientist Jessica Grahn of Western University in London, Canada. “It’s a way to have social participation.” Study participants were split into groups of 20 and experienced music in one of three ways. Some watched a live concert with a large audience, some watched a recording of the concert with a large audience, and some watched the recording with only a few other people. Each person wore EEG caps, headwear covered with electrodes that measure the collective behavior of the brain’s nerve cells. The musicians played an original song they wrote for the study. The delta brain waves of audience members who watched the music live were more synchronized than those of people in the other two groups. Delta brain waves fall in a frequency range that roughly corresponds to the beat of the music, suggesting that beat drives the synchronicity, neuroscientist Molly Henry, a member of Grahn’s lab, reported. The more synchronized a particular audience member was with others, the more he or she reported feeling connected to the performers and enjoying the show. |© Society for Science & the Public 2000 - 2018

Keyword: Hearing
Link ID: 24800 - Posted: 03.30.2018

By KAREN BARROW Creepy-crawly, itchy, tingly, aching legs — while different people may describe restless leg syndrome differently the results are the same: sleepless nights and restless days. What is it like to be diagnosed with R.L.S.? Six men and women speak about their experiences. Lynne Kaiser, an artist, believes she has had restless leg syndrome for most of her life. She recalls waking up in the middle of the night as a child to take a hot bath or fill a hot water bottle to try to relieve the prickly sensations in her legs. It wasn’t until recently that a specialist confirmed the diagnosis. Today, Mrs. Kaiser advocates for R.L.S. patients. Dopaminergic medications, as well as art and needlework, help her to “get in a tunnel” where she can be distracted from the uncomfortable sensations, she said. Mrs. Kaiser says the symptoms of R.L.S. strained her relationship with her husband. He couldn’t understand why she couldn’t just relax in bed with him, or why she would get up at night to stretch her legs or sit in a scalding hot bath. Because of R.L.S., Mrs. Kaiser finds it difficult to travel. She also knows that R.L.S. medications tend to lose their effectiveness over time, so she focuses on how good she feels today. “I really try not to think about the future,” she said. Dr. David Rye, a professor of neurology at Emory University in Atlanta, discovered that he had restless leg syndrome several years after he began researching the disease. He says that many in the medical community believe that R.L.S. is a psychological disease rather than a physical ailment. However, Dr. Rye and his colleagues were among the first to discover a gene variant linked to R.L.S. Genetic factors help to explain why R.L.S. is so much more prevalent among Caucasians than other ethnicities. © 2018 The New York Times Company

Keyword: Sleep
Link ID: 24799 - Posted: 03.29.2018

Martha Bebinger A pipe was the only sign of drug use found near Chris Bennett's body in November. But it looked like the 32-year-old Taunton, Mass. native had stopped breathing and died of an opioid overdose. Bennett's mother Liisa couldn't understand what happened. Then she saw the toxicology report. "I'm convinced he was smoking cocaine that was laced," she says. "That's what he had in his system, [it] was cocaine and fentanyl." Liisa Bennett was shocked. Chris had developed an addiction to pain pills and then heroin in his late teens but had not used opioids for at least 10 years, as far as she knew. Bennett had warned her son that if he ever used opioids again, he'd be in greater danger of an overdose because fentanyl, an opioid drug more powerful than heroin, was mixed into much of the supply. "My focus was making sure that he wasn't going to do the heroin that was laced," Bennett says. She never suspected the crack cocaine Chris smoked occasionally would kill him. "Absolutely not." The Centers for Disease Control and Prevention says fentanyl, which is up to 50 times more powerful than heroin, was found in more than half of overdose deaths last year in 10 states including Massachusetts. Now, there's concern as it creeps into cocaine. © 2018 npr

Keyword: Drug Abuse
Link ID: 24798 - Posted: 03.29.2018

By Laura Sanders U.S. deaths from opioid overdoses are mounting with breathtaking speed. These powerful drugs — including heroin, morphine and fentanyl — can relieve pain and evoke intense feelings of pleasure. But the same drugs, whether prescribed by a doctor or bought on the street, can quickly turn deadly by simultaneously messing with crucial systems in the body. Among the many rapid effects that opioids have on the body, one is particularly lethal: Breathing is restricted. “Opioids kill people by slowing the rate of breathing and the depth of breathing,” says medical toxicologist and emergency physician Andrew Stolbach of Johns Hopkins University School of Medicine. Breathing delivers fresh oxygen to the body’s cells and eliminates carbon dioxide. Opioids can interfere with that life-sustaining process in multiple, dangerous ways. Here’s how opioids kill. In the brain stem, regions called the medulla and the pons control the depth and rate of breathing. Both are loaded with opioid receptors — proteins that sit on the surface of cells and grab onto opioids. Upon activating, the receptors change the behavior of cells in ways that can slow or even stop breathing.

Keyword: Drug Abuse
Link ID: 24797 - Posted: 03.29.2018

By Catherine Offord A tadpole has a lot of growing to do to get up to the size it needs to be to metamorphose into an adult frog or toad. Now, researchers at the University of Michigan suggest that this rapid growth is made possible by a lack of inhibitory feeding controls prior to metamorphosis. The team reports the absence of these controls, along with the hormonal regulation that accompanies it, today (March 28) in Proceedings of the Royal Society B. “Our findings are consistent with the hypothesis that the strong drive to eat prior to metamorphosis is due to the absence, or the relative immaturity of hypothalamic feeding control circuits,” the authors write in their paper. This lack of inhibition helps allow “the animal to maximize growth during this critical life-history stage.” Previous work by the researchers had implicated a role for leptin, a hormone that acts as a hunger inhibitor in vertebrates, in regulating the changing feeding habits of toads during early development. To investigate how this hormone might prepare juvenile amphibians for metamorphosis, the team analyzed levels of mRNA transcripts for leptin receptor proteins and for the hormone itself in tadpoles of the African clawed frog (Xenopus laevis). The researchers found that the tadpoles were essentially unresponsive to leptin, unlike their adult counterparts, and showed minimal expression of the leptin receptor in the hypothalamus—a key brain region in the regulation of feeding behavior. Instead, these responses develop as the relevant neural circuits mature during metamorphosis, the authors write. © 1986-2018 The Scientist

Keyword: Obesity
Link ID: 24796 - Posted: 03.29.2018

by Ariana Eunjung Cha) Sally Clark lost both her infant sons shortly after their births. In 1996, 11-week-old Christopher fell unconscious after being put to bed and never woke up. Two years later, 8-week-old Harry was found dead slumped forward in his bouncy chair. Doctors initially concluded the first boy had died of sudden infant death syndrome (SIDS) — in which a seemingly healthy baby dies without warning and without an obvious cause. But after Clark's second child died, prosecutors in the United Kingdom charged her with murder and put her on trial. According to scholars analyzing the widely publicized case, Clark was wrongly convicted based on a statistic. An expert witness for the prosecution claimed the chance of two cases of SIDS, in an affluent family like hers, was astronomically high — 1 in 73 million. Her defenders said the numbers assumed that SIDS strikes at random, even though we had no idea back then whether that was true. An important study published Wednesday in the Lancet shows a link between SIDS and a rare genetic mutation that would make some families more vulnerable than others — providing a possible explanation for situations like Clark's. The research involved 278 infants who died of SIDS, also called “crib death” or “cot death,” and 729 healthy controls. Four of those who died of SIDS had a variant of a gene called SCN4A associated with an impairment of breathing muscles, while no babies in the control group had it. Authors Michael Hanna from the United Kingdom's Medical Research Council's Center for Neuromuscular Diseases and Michael Ackerman from the Mayo Clinic in the United States wrote that these mutations are typically found in fewer than 5 out of 100,000 people. © 1996-2018 The Washington Post

Keyword: Sleep; Genes & Behavior
Link ID: 24795 - Posted: 03.29.2018

By NICHOLAS BAKALAR Being physically fit in midlife may reduce a woman’s risk for dementia. In 1968, Swedish researchers evaluated the cardiovascular fitness of 191 women ages 38 to 60, testing their endurance with an ergometer cycling test. Then they examined them periodically through 2012. Over the years, 44 women developed dementia. They categorized the women into three fitness groups based on peak workload in their cycling tests: low, medium and high. The incidence of all-cause dementia was 32 percent in the low fitness group, 25 percent for the medium, and 5 percent among those with a high fitness level. The average age at dementia was 11 years older in the high-fitness group than in the medium fitness group. Compared with medium fitness, high fitness decreased the risk of dementia by 88 percent. The study, in Neurology, controlled for many variables, including smoking, drinking, blood pressure and cholesterol, and the follow-up was very long. But the sample was small and the study is observational, and the authors draw no conclusions about cause and effect. Still, the senior author, Dr. Ingmar Skoog, a professor of psychiatry at the University of Gothenburg, said that women should get moving for many reasons. “If you start exercising,” he said, “you reduce your risk for cardiovascular disease, cancer and dementia. And you get immediate gratification by feeling better.” © 2018 The New York Times Company

Keyword: Alzheimers
Link ID: 24794 - Posted: 03.29.2018

Sara Reardon Jhon Kennedy was building a house for his family when he realized that his 45-year-old father was beginning to struggle with daily life. His dad tried to help with the construction project but often forgot to complete simple tasks. And he kept getting lost on the way home from work. Jhon Kennedy wasn’t surprised: his four uncles had also started to lose their memories, one by one. But their doctors in Colombia's rural Antioquia region, which is known for its mountainous terrain and coffee plantations, had never heard of early-onset dementia. It wasn’t until a cousin learned about a study of Alzheimer’s disease at the University of Antioquia in Medellín that Jhon Kennedy’s relatives understood the illness they faced. For more than three decades, researchers there have been tracking a genetic mutation — common in the region — that causes Alzheimer’s to strike people in their 40s and 50s. Later this year, a team at the university will begin scanning the brains of some Alzheimer’s-study participants with a technique that is available only in a few major medical centres worldwide. It will allow the researchers to track a protein called tau, which accumulates rapidly in the brains of people with the disease as symptoms begin to emerge. Watching tau form in real time could reveal the role it plays in Alzheimer’s, says Francisco Lopera, the neurologist who is leading the research. Many scientists have long believed that the disease is triggered by another protein, amyloid, that builds up in the brains of people with Alzheimer’s. But several drugs that reduce amyloid levels have failed to relieve the symptoms of the disease in clinical trials, increasing researchers’ interest in the role of tau. © 2018 Macmillan Publishers Limited,

Keyword: Alzheimers; Learning & Memory
Link ID: 24793 - Posted: 03.28.2018

By RANDI HUTTER EPSTEIN Getting a high testosterone reading offers bragging rights for some men of a certain age — and may explain in part the lure of testosterone supplements. But once you are within a normal range, does your level of testosterone, the male hormone touted to build energy, libido and confidence, really tell you that much? Probably not, experts say. Normal testosterone levels in men range from about 300 to 1,000 nanograms per deciliter of blood. Going from one number within the normal zone to another one may not pack much of a punch. “You don’t see the big improvement once men are within the normal range,” said Dr. Shalender Bhasin, an endocrinologist and professor of medicine at Harvard Medical School. The largest differences in terms of energy and sex drive are when men go from below-normal to normal levels. A 2015 study in JAMA found that sex drive improved among men who went from about 230, considered low, to 500, around the middle of what’s considered normal. There was no difference among men who moved within the normal range from 300 to 500. Testosterone does influence muscle size. The more testosterone a man takes, the larger the muscle — regardless of starting level, one reason the hormone is popular with young bodybuilders. But testosterone supplements do not seem to help frail older men walk farther or get out of chairs more easily, goals that doctors typically look for in aiding older patients. Beginning at age 30, testosterone levels drop, on average, about 1 percent a year. About 5 percent of men between the ages of 50 and 59 have low levels of testosterone along with symptoms like loss of libido and sluggishness, according to a few small studies. © 2018 The New York Times Company

Keyword: Hormones & Behavior; Sexual Behavior
Link ID: 24792 - Posted: 03.28.2018

By JAN HOFFMAN Medicare officials thought they had finally figured out how to do their part to fix the troubling problem of opioids being overprescribed to the old and disabled: In 2016, a staggering one in three of 43.6 million beneficiaries of the federal health insurance program had been prescribed the painkillers. Medicare, they decided, would now refuse to pay for long-term, high-dose prescriptions; a rule to that effect is expected to be approved on April 2. Some medical experts have praised the regulation as a check on addiction. But the proposal has also drawn a broad and clamorous blowback from many people who would be directly affected by it, including patients with chronic pain, primary care doctors and experts in pain management and addiction medicine. Critics say the rule would inject the government into the doctor-patient relationship and could throw patients who lost access to the drugs into withdrawal or even provoke them to buy dangerous street drugs. Although the number of opioid prescriptions has been declining since 2011, they noted, the rate of overdoses attributed to the painkillers and, increasingly, illegal fentanyl and heroin, has escalated. “The decision to taper opioids should be based on whether the benefits for pain and function outweigh the harm for that patient,” said Dr. Joanna L. Starrels, an opioid researcher and associate professor at Albert Einstein College of Medicine. “That takes a lot of clinical judgment. It’s individualized and nuanced. We can’t codify it with an arbitrary threshold.” Underlying the debate is a fundamental dilemma: how to curb access to the addictive drugs while ensuring that patients who need them can continue treatment. © 2018 The New York Times Company

Keyword: Pain & Touch; Drug Abuse
Link ID: 24791 - Posted: 03.28.2018

By Virginia Morell As every dog lover—and scientist—knows, man’s best friend is good at reading faces. Dogs can tell the difference between happy and not-so-happy expressions, such as anger and sadness. Like us, they watch the left sides of peoples’ faces—where emotional cues first appear. And they even seem to be able to interpret our emotions and modulate their behavior accordingly. But what are the neural mechanisms that control how dogs process human faces? To find out, scientists trained eight dogs—mostly border collies—to lie still in a functional magnetic resonance imaging scanner while viewing photos of strangers with either happy or neutral expressions. The faces matched the gender of the dogs’ chief caretakers, because dogs have been shown to score lower on tasks involving faces of the opposite sex. The results: A happy human face produces a distinctive signature in a dog’s temporal lobe and other neural regions, the scientists report online this week on the preprint server bioRxiv. In a follow-up experiment, the pooches’ brains were scanned as they looked at faces expressing happiness, anger, fear, or sadness. The happiness pattern was so distinctive that a machine learning program could pick it out from brain activity linked to all the other emotions. (A similar “happiness” signature is found in humans.) That means, the researchers say, that our human emotions are represented in our pooches’ brains—which suggests that our canine pals really do know what we’re feeling. © 2018 American Association for the Advancement of Science.

Keyword: Emotions; Animal Communication
Link ID: 24790 - Posted: 03.28.2018

By GINA KOLATA It was one of those findings that would change medicine, Dr. Christopher Lewandowski thought. For years, doctors had tried — and failed — to find a treatment that would preserve the brains of stroke patients. The task was beginning to seem hopeless: Once a clot blocked a blood vessel supplying the brain, its cells quickly began to die. Patients and their families could only pray that the damage would not be too extensive. But then a large federal clinical trial proved that a so-called clot-buster drug, tissue plasminogen activator (T.P.A.), could prevent brain injury after a stroke by opening up the blocked vessel. Dr. Lewandowski, an emergency medicine physician at Henry Ford Health System in Detroit and the trial’s principal investigator, was ecstatic. “We felt the data was so strong we didn’t have to explain it” in the published report, he said. He was wrong. That groundbreaking clinical trial concluded 22 years ago, yet Dr. Lewandowski and others are still trying to explain the data to a powerful contingent of doubters. The skeptics teach medical students that T.P.A.is dangerous, causing brain hemorrhages, and that the studies that found a benefit were deeply flawed. Better to just let a stroke run its course, they say. It’s a perspective with real-world consequences. Close to 700,000 patients have strokes caused by blood clots each year and could be helped by T.P.A. Yet up to 30 percent of stroke victims who arrive at hospitals on time and are perfect candidates for the clot-buster do not receive it. The result: paralysis and muscle weakness; impaired cognition, speech or vision; emotional and behavioral dysfunction; and many other permanent neurological injuries. © 2018 The New York Times Company

Keyword: Stroke
Link ID: 24789 - Posted: 03.27.2018

Rachel Ehrenberg BOSTON — Conflicting results on whether brain stimulation helps or hinders memory may be explained by the electrodes’ precise location: whether they’re tickling white matter or gray matter. New research on epilepsy patients suggests that stimulating a particular stretch of the brain’s white matter — tissue that transfers nerve signals around the brain — improves performance on memory tests. But stimulating the same region’s gray matter, which contains the brain’s nerve cells, seems to impair memory, Nanthia Suthana, a cognitive neuroscientist at UCLA, reported March 25 at a meeting of the Cognitive Neuroscience Society. A groundbreaking study by Suthana and colleagues, published in 2012 the New England Journal of Medicine, found that people performed better on a memory task if their entorhinal cortex — a brain hub for memory and navigation — was given a low jolt of electricity during the task. But subsequent studies stimulating that area have had conflicting results. Follow-up work by Suthana suggests that activating the entorhinal cortex isn’t enough: Targeting a particular path of nerve fibers matters. “It’s a critical few millimeters that can make all the difference,” said Suthana. The research underscores the complexity of investigations of and potential treatments for memory loss, said Youssef Ezzyat, a neuroscientist at the University of Pennsylvania. Many variables seem to matter. Recent work by Ezzyat and colleagues found that the kind of brain activity during stimulation is also important, as is the precise timing of the stimulation (SN: 3/31/2018, p.16). |© Society for Science & the Public 2000 - 201

Keyword: Learning & Memory
Link ID: 24788 - Posted: 03.27.2018

by Amy Ellis Nutt In the first comprehensive imaging study of attention-deficit/hyperactivity disorder in preschoolers, researchers have found evidence that structural changes in the brain are already recognizable at the age of 4. “One of our big questions was thinking about an early-onset disorder and linking it to early-onset brain anomalies,” said Lisa Jacobson, one of the researchers involved in the study, which appeared Monday in the Journal of the International Neuropsychological Society. The results “tell us that this is not just a behavioral disorder. It is a neurological disorder.” The study found widespread reductions in the volume of gray matter in the brains of children with ADHD. And the more severe their behavior, the more their brains differed from those of children who were not diagnosed with ADHD, according to Jacobson, a pediatric neuropsychologist at Johns Hopkins University and the Kennedy Krieger Institute, an affiliate of Johns Hopkins and the site of the research. The most significant differences in brain volume were seen in the temporal and prefrontal lobes, including areas associated with activity, attention and motor control. The results seen in the preschoolers mirror those of earlier research in school-age children and adolescents. “When they designed the study, even [lead author] Mark Mahone did not think he would find these differences,” said James Griffin of the National Institutes of Health, which funded the research. Griffin is the deputy chief of NIH’s Child Development and Behavior branch. “They were surprised at how early these differences were already evident in the brain.” © 1996-2018 The Washington Post

Keyword: ADHD; Development of the Brain
Link ID: 24787 - Posted: 03.27.2018

Bruce Bower Groove patterns on the surface of modern chimpanzee brains throw a monkey wrench into proposals that some ancient southern African hominids evolved humanlike brain characteristics, a new study suggests. MRIs of eight living chimps reveal substantial variability in the shape and location of certain features on the brain surface. Some of these brains showed surface creases similar to ones that were thought to have signaled a turn toward humanlike brain organization in ancient hominids hundreds of thousands, if not millions, of years ago. Paleoanthropologist Dean Falk of Florida State University in Tallahassee and colleagues report their findings online March 13 in Brain, Behavior and Evolution. The study casts doubt on a 2014 paper by Falk that was based on casts of the inside of fossil braincases, called endocasts, which preserve impressions of these surface features. At the time, Falk argued that four endocasts from southern African hominids — three Australopithecus africanus and one Australopithecus sediba — showed folding patterns that suggested that brain reorganization was underway as early as 3 million years ago in a frontal area involved in human speech production. But MRIs of three of the chimp brains reveal comparable creases, the researchers found. Two other chimps display other frontal tissue furrows that Falk had also previously described as distinctly humanlike. |© Society for Science & the Public 2000 - 2018

Keyword: Evolution
Link ID: 24786 - Posted: 03.27.2018

by David Kohn This is a story about the importance of good timing. Two-thirds of Americans are overweight or obese. This excess weight contributes to a variety of health problems. Despite enormous effort over decades, the problem has proved extremely difficult to solve. Biologist Satchin Panda thinks we’re missing a key variable: Instead of focusing so much on what we eat, he says, we should pay more attention to when we eat. A researcher at the Salk Institute in San Diego, Panda argues that eating within a certain time window each day can help people lose weight and may help prevent illnesses including diabetes, heart disease and cancer. In animal studies, he and others have shown that limiting food intake to a period of eight to 12 hours can boost cognitive and physical performance, and may even lengthen life span. Known as time-restricted feeding, or TRF, the approach is simple: Eat more or less what you want, but don’t consume anything before or after the allotted time. Panda argues that humans’ circadian rhythm is not designed for a world with 24-7 access to food. “If you’re eating all the time, it messes up that pattern,” he says. For many if not most Americans, that pattern is deeply out of whack, and many of us eat from early morning until late at night. © 1996-2018 The Washington Post

Keyword: Obesity
Link ID: 24785 - Posted: 03.27.2018

By Abby Olena Some mouse mothers groom, lick, and nurse their babies more than others. In a study published in Science today (March 23), researchers demonstrate that this natural variation in maternal behavior is linked to the structure of pups’ genomes, specifically, the activation of one of the most common jumping genes in the genome, LINE-1. “What’s fascinating about the paper is the connection between experience, epigenetics, and restructuring of the genome,” says Moshe Szyf, a geneticist at McGill University in Montreal who did not participate in the work. “We usually think about epigenetics changes that don’t change the sequence, but here there was a connection of the maternal care, the change in methylation . . . and then restructuring.” Coauthor Tracy Bedrosian, who did the work as a postdoc at the Salk Institute and is now a scientist at Ohio-based Neurotechnology Innovations Translator, and her colleagues did not set out to study maternal behavior. Instead, they wanted to explore the effects of maternal stress and environmental enrichment on the retrotransposon LINE-1 (L1), which can copy and paste itself into new locations in the genome, in pups. To manipulate stress levels, they isolated and confined pregnant mice to a small area for a couple hours each day, and for enrichment, mice lived in groups in a large enclosure with toys and running wheels. Bedrosian says that they saw wild variations in L1 copy number between different litters of mice that didn’t seem to relate to their experimental manipulations. Perhaps, they reasoned, maternal behavior was involved. © 1986-2018 The Scientist

Keyword: Epigenetics; Sexual Behavior
Link ID: 24784 - Posted: 03.26.2018