Alison Abbott The development of the human brain, with its extraordinary range of cognitive abilities, is an awe-inspiring feat of evolution. Each of its tens of billions of cells must be born at precisely the right time, migrate to the correct locations, differentiate into as many as 3,000 distinct cell types, and form exquisitely specific synaptic connections with one another. Most of this happens before birth, but development continues for nearly three more decades. None of this is easy to study. Conventionally, scientists have relied on animal models and scarce human brain tissue. But the advent of tiny laboratory-grown models of human brains called organoids has transformed their options. First created more than a decade ago, these organoids started off as very simple models. But in the past few years, scientists have refined the technology to grow more-intricate systems that represent more brain regions. Research has snowballed as scientists have used organoids to probe brain development, model neurodevelopmental conditions such as autism and schizophrenia and test new treatments for brain diseases. These tiny spheres are helping researchers to get at difficult-to-answer questions such as why the human brain develops so much more slowly than other mammalian brains do. And this year, researchers are hoping to run the first clinical trial of a brain-disorder treatment developed entirely in organoids. “The field is at an inflection point,” says developmental biologist Jürgen Knoblich at the Institute for Molecular Biotechnology in Vienna. But organoids are not without their limitations. It’s hard to sustain them in the lab for more than a few months, for instance. And they lack complexity. © 2026 Springer Nature Limited

Keyword: Development of the Brain
Link ID: 30194 - Posted: 04.08.2026

By Andrew Jacobs As researchers have sought to demonstrate the therapeutic benefits of mind-altering drugs like LSD and psilocybin “magic mushrooms,” many have struggled to explain exactly how these compounds work on the human brain. One way scientists have tried to show what these compounds do is by using functional M.R.I. machines to peer into the brains of research participants in the midst of a psychedelic experience. This has produced evocative color images that show a maelstrom of activity as the drugs disrupt patterns of connectivity between brain regions and networks. But the interpretations of those scans, published in scientific journals, have been inconsistent and even contradictory. Over the past five years, an international consortium of researchers has tried to make sense of the divergent results by bringing together the data from nearly a dozen brain imaging studies in five countries that have been published since 2012. The studies included more than 500 scans of 267 research participants on five substances: LSD, psilocybin, mescaline, DMT and ayahuasca. Their findings, published on Monday in the journal Nature Medicine, suggest that psychedelics prompt a welter of activity between regions of the brain that normally operate somewhat independently: the areas that process sensory information like vision, hearing and touch, and those involved with abstract thinking and self-reflection. The research suggests that psychedelic compounds temporarily reduce the separation between how we think and how we perceive, which could explain the neurological mechanics behind the sensory distortions, mystical experiences and ego dissolution that patients report during sessions. © 2026 The New York Times Company

Keyword: Drug Abuse; Consciousness
Link ID: 30193 - Posted: 04.08.2026

By Mac Shine The brain is arguably the most complex object in the known universe, and neuroscience—the discipline charged with understanding it—has grown to match that complexity. Today, the field spans everything from the molecular choreography of a single synapse to the large-scale network dynamics that give rise to conscious experience. It is simultaneously one of the most exciting and most disorienting fields to work in. The conceptual map that connects our different subfields hasn’t been written yet. But a new study published in Aperture Neuro in February takes a remarkable step toward drawing that map. Led by Mario Senden, a computational neuroscientist at Maastricht University, the work applies state-of-the-art text embedding and community detection algorithms to nearly half a million neuroscience abstracts published between 1999 and 2023. It carves the literature into 175 distinct research clusters, characterizing each one along dimensions ranging from spatial scale to theoretical orientation. What emerges is a portrait of a discipline that is, in many ways, healthier than it might appear from the inside. Despite its staggering diversity—clusters range from AMPA receptor trafficking to the neural underpinnings of consciousness—the field is remarkably well integrated; the vast majority of research communities actively draw on and feed into one another. The cluster of resting-state functional MRI dynamics and the molecular mechanisms of hippocampal plasticity emerge as some of the field’s great intellectual hubs, providing conceptual and methodological scaffolding for dozens of downstream communities. But the map also has its fault lines. Microscale and macroscale research communities operate in two largely separate epistemic worlds, divided by spatial scale and by the training trajectories that produce different kinds of neuroscientists. Temporal scales are integrated only pairwise, never holistically. And perhaps most provocatively: Not a single cluster in the entire 175-cluster solution is organized around a theoretical framework. The Bayesian brain, the free energy principle and predictive coding are common targets of empirical science, yet none of them anchor their own research community. Theory, it seems, is something neuroscience does around the edges of the phenomena it is really interested in. © 2026 Simons Foundation

Keyword: Attention
Link ID: 30192 - Posted: 04.08.2026

By Erin Garcia de Jesús My early days of nursing a newborn felt like I’d transformed into a 24-hour diner. A demanding yet adorable customer flagged me down with piercing cries to demand milk around the clock. Unfortunately, I was also on clean-up duty, wiping spit-ups and poopy butts. Breastfeeding is hard work. But after reading science journalist Elizabeth Preston’s book The Creatures’ Guide to Caring, I’m glad I’m not a burying beetle. The critters use mouth and anal secretions to knead small dead animals into slick balls of meat. Parent beetles then bury the smothered carcasses and lay their eggs nearby. Some species even feed their brood regurgitated bits of carcass, helping the young beetles grow to 200 times their original size in just six days. “A newborn human growing at that rate would be the size of a beluga whale in less than a week,” Preston writes. Suddenly my own kid doesn’t seem so heavy. The Creatures’ Guide to Caring was born out of Preston’s growing fascination with the biology of parenting after having her first child. “If so many people have done it before you, and are doing it right now — if so many animals are doing it without books or apps or advice to heed — why is it the hardest thing you’ve ever done?” she writes. Perhaps by finding kinship in the animal world, Preston could learn something about her new role as a parent. Each chapter dissects the benefits and drawbacks of parenting, piecing together how it evolved in humans and other creatures. © Society for Science & the Public 2000–2026

Keyword: Sexual Behavior; Evolution
Link ID: 30191 - Posted: 04.08.2026

By Claudia López Lloreda A previously unrecognized population of fibroblasts seals off the base of the choroid plexus—the network of blood vessels and cerebrospinal-fluid-producing epithelial cells that line the ventricles—from the cerebrospinal fluid (CSF) and the rest of the brain, a new study in mice shows. The newly identified barrier provides an added layer of protection that is distinct from the well-known blood-brain barrier and the one that the epithelial cells form between the blood and the CSF. The findings help settle a long-standing debate about whether there was a blind spot in the choroid plexus that gave the periphery access into the brain, says Britta Engelhardt, professor of immunobiology at the University of Bern, who was not involved in the work. “Some [scientists] speculated that there is a leak, like an opening, a secret window into the brain, and others said, ‘No, there must be a barrier that we have overlooked.’ And it’s very obvious now.” Fibroblasts at the base of the choroid plexus, connected by adherens and tight junction proteins, cluster together around blood vessels and form a sealed barrier in mice, the researchers found. This structure represents a crucial component of compartmentalization in the choroid plexus, Engelhardt says. The cells were also present in human postmortem brain samples. Similar to other barriers, the seal becomes leaky in response to inflammation triggered by lipopolysaccharide, a component of the bacterial cell wall, and it may coordinate immune cell crossing from the blood into the brain, the study also showed. The work was published in February in Nature Neuroscience. © 2026 Simons Foundation

Keyword: Neuroimmunology; Drug Abuse
Link ID: 30190 - Posted: 04.04.2026

Marielle Segarra When neurosurgeon and journalist Dr. Sanjay Gupta set out to write a book about pain, it wasn't because he felt like he had all the answers. It was because he was still so often mystified by it. "Most of my patients come to me for pain. Head pain, back pain, neck pain, whatever it might be," he says. "If that's what the majority of your professional life is, you should understand it as best you can." His 2025 book, It Doesn't Have to Hurt: Your Smart Guide to a Pain-Free Life, gathers the latest developments in pain science, based on his own experience with patients and conversations with researchers and doctors. What he found may challenge your own understanding of pain and even give you the tools to help you feel better. There's evidence, for example, that just learning about pain and how it works "seems to be pain relieving" for those with chronic pain conditions, he says. Gupta, who also serves as the chief medical correspondent for CNN, explains what we still don't know about pain and shares a few effective new treatments. This interview has been edited for length and clarity. In your book, you say that one of the most significant developments emerging in pain treatment is the fact that the brain is at the center of any pain experience. Can you tell us more about why that matters? What I think has become clear — and I'm not the first person to say this — is the idea that if the brain doesn't decide you have pain, then you don't have pain. © 2026 npr

Keyword: Pain & Touch; Attention
Link ID: 30189 - Posted: 04.04.2026

By Diana Kwon Human minds often wander. Whether we’re busy at work, doing chores or exercising, our thoughts frequently shift away from the task at hand. These spontaneous thoughts sometimes turn toward sensations in the body, such as our heartbeat or breath, and that could affect our immediate emotional state and long-term mental health, researchers report March 25 in Proceedings of the National Academy of Sciences. Many studies focus on thinking about memories, events and other people, what scientists consider the cognitive aspects of mind wandering, says Micah Allen, a neuroscientist at Aarhus University in Denmark. This research suggests that mind wandering plays an important role in planning, learning, creativity and other important mental processes. It has also been linked to negative emotions and some, such as obsessively ruminating on past mistakes, may contribute to depression, attention-deficit/hyperactivity disorder and other mental illnesses. Do you share our vision for a healthier, happier world through science? But how the mind might drift to bodily sensations, what some researchers call “body wandering,” and its effects have largely been overlooked, Allen says. He and colleagues had 536 people lie still in a magnetic resonance imaging scanner and then complete a questionnaire about what was on their minds during that time. In addition to the typical content of daydreams, such as memories, plans or social interactions, participants reported paying attention to sensations in their body, such as their breathing, heartbeats and bladder. The team also found evidence of this in the MRI scans: Body wandering appeared to have a distinct brain signature from that of “cognitive” mind wandering. © Society for Science & the Public 2000–2026.

Keyword: Stress; Attention
Link ID: 30188 - Posted: 04.04.2026

By Jake Currie Ever wonder why jet lag is such a horribly uncomfortable experience? It’s because your biological clock doesn’t just regulate your sleep cycle, it affects a whole host of other bodily functions, like hormone levels, metabolism, your immune activity, and more. That means when your circadian rhythms get disrupted, it can throw a wrench into a variety of systems. It also means that time of day can be an important factor when considering medical treatments. For example, aortic valve replacements performed in the afternoon are associated with fewer adverse side effects. Unfortunately determining what “time” your internal clock reads is a little more difficult than glancing at a watch, in part because everyone’s biological clock ticks at a slightly different pace. Right now, the single most accurate test involves repeatedly measuring the levels of melatonin in the saliva during the hours leading up to bedtime, which is difficult to do outside of a laboratory or hospital environment. Now, according to new research published in the Proceedings of the National Academy of Sciences, chronobiologists have developed a way to get an accurate read of your biological clock from a simple hair sample. By measuring the transcriptional activity of clock genes in hair follicle cells and performing an analysis using artificial intelligence, they’ve been able to accurately pinpoint the biological clock’s time. “In these cells, we measure the activity of 17 genes that are part of the molecular clock or are controlled by it,” study author Achim Kramer of Charité—Universitätsmedizin Berlin explained in a statement. “Using machine learning, this pattern can be used to calculate at what point in the daily rhythm the person is currently at. A single sample is sufficient for this.”

Keyword: Biological Rhythms; Genes & Behavior
Link ID: 30187 - Posted: 04.04.2026

By Ellen Barry When Cohen Miles-Rath walks into his father’s house, the history of his psychosis is right there in front of him. There is the place where he was standing when he received a cryptic message on his phone: The devil had entered his father’s body. There is the drawer where he spotted a knife whose handle was white — the color of God! There is the floor where, as they grappled over the knife, Cohen bit off part of his father’s earlobe, and blood spattered over both of them. There is the spot where, pinned to the floor, Cohen reached up with the knife and slashed wildly at his father’s throat. The violence lasted seconds but changed his whole life. With voices still racketing in his head, Cohen found himself in jail, facing charges of second-degree assault and criminal mischief, felonies punishable by up to 10 years in prison. Stunned and bleeding, his father had pressed charges, and taken out a restraining order against him. But Cohen hadn’t killed him. In the years that followed, he had the feeling that he had walked right up to the edge of a chasm. About 300 times a year in the United States, a child kills a parent, making up around 2 percent of all homicides. A large portion of these cases involve people like Cohen: young men with severe mental illness who are living at home. When mounting symptoms of psychosis make school or work impossible, parents are the support system of last resort. Paranoid delusions can cruelly invert that logic, turning people against the figure closest to them. © 2026 The New York Times Company

Keyword: Schizophrenia; Aggression
Link ID: 30186 - Posted: 04.01.2026

By Jennie Erin Smith For a person who may be in the early stages of Alzheimer’s disease, getting a clear diagnosis is simpler than ever. Blood tests that detect biological changes linked to the disease are now considered reliable alternatives to brain imaging and invasive spinal fluid tests. And one biomarker, called phosphorylated tau 217 (p-tau217), has risen to the top. More accurate than other blood-based measures, p-tau217 is widely used in research, and the first commercial test was approved in the United States last year. Guidance from the influential Alzheimer’s Association says a positive result in a patient with cognitive symptoms can justify starting therapy with antibody drugs recently approved for the disease. “P-tau217 is the biomarker of the day,” says Alzheimer’s researcher Lon Schneider of the University of Southern California. But its success has sparked worries among some researchers and clinicians about inappropriate use of the test. Some doctors have begun to use it in people without confirmed symptoms, and telehealth companies peddle p-tau217 testing, for as little as a few hundred dollars, to anyone concerned about their memory. A positive result doesn’t mean a person will develop cognitive impairment or dementia, Schneider and other researchers warn. And some fear the tests will be used to push people without symptoms toward pricey infusion drugs that they may not need. At the Alzheimer’s Disease and Parkinson’s Disease (AD/PD) meeting last month in Copenhagen, Denmark, scientists seemed to agree that for better or for worse, p-tau217 is poised to become a widespread screening tool for healthy people. That assumption is driving an ongoing trial called TRAILBLAZER-3, in which people with positive p-tau217 but no symptoms are taking the antiamyloid drug donanemab to see whether it delays the onset of cognitive impairment. “People keep thinking or talking about early treatment,” says neurologist Richard Mayeux of Columbia University, who is not involved with that study. “What you want to do is get to that fine area just before cognitive impairment starts to occur.” © 2026 American Association for the Advancement of Science.

Keyword: Alzheimers
Link ID: 30185 - Posted: 04.01.2026

Anne-Laure Le Cunff It’s Monday morning at the lab and I have a team presentation due in two hours. I open my laptop intending to tweak a figure, then notice a paper I’d bookmarked. That paper cites another, which leads me to one of the authors’ new preprints. Soon I find myself with 27 tabs open, three half-formed ideas scribbled in my notebook, and a new app downloaded to prototype something that has nothing to do with my presentation. I know I should stop and I can feel the time pressure building, but the pull to wander is too strong – almost physical. Just five more minutes, I promise to myself, and I’ll return my attention to the ‘real’ work. Only when my anxiety becomes impossible to ignore do I force myself to come back to the slides. This little dance isn’t unusual for me and the millions of other people who can spend hours in deep, almost joyful focus when a question grabs our attention, but who can also derail ourselves completely when we hear about a shiny new idea. For a long time, I thought this was a personal failure of discipline, a quirk I needed to manage better. It’s only when I started working at the ADHD Research Lab at King’s College London that I came to believe it might be something else entirely. I’m a cognitive neuroscientist using behavioural experiments, eye-tracking and EEG to examine how attention is drawn toward some signals and away from others. In retrospect, the irony isn’t lost on me that I spent years studying attention without applying the same analytic lens to myself. To understand why I’d dismissed my own experience for so long, it helps to look at how ADHD is officially defined. ADHD, or attention deficit hyperactivity disorder, is characterised in the current edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) as ‘a persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development.’ The emphasis is on impairment: something is not working as it should. © Aeon Media Group Ltd. 2012-2026.

Keyword: ADHD
Link ID: 30184 - Posted: 04.01.2026

By Trip Gabriel Dr. Judith L. Rapoport, a child psychiatrist who brought public awareness to obsessive-compulsive disorder with her best-selling 1989 book, “The Boy Who Couldn’t Stop Washing,” based on her groundbreaking research into the condition’s causes and treatment, died on March 7 in Washington, D.C. She was 92. Her death, at a retirement home, was from lung cancer, her husband, Stanley Rapoport, said. Dr. Rapoport’s book about obsessive-compulsive disorder, written in an engaging style for nonscientific readers, clarified that the condition was far more common than generally thought, affecting some 1 to 3 percent of the population. The disorder had long remained in the shadows because of the shame that surrounded its symptoms, which could include habits like checking and rechecking that appliances were off, performing counting rituals before doing something as simple as walking through a doorway, or scrubbing hands with soap and water until the skin was raw — any of which, uncontrollably repeated, might waste hours of the day. Dr. Rapoport showed that there was a neurological basis for obsessions, or intrusive repetitive thoughts, and also for their linked compulsions, or pointless rituals of behavior. Along with other researchers in the 1980s, she upended the received psychiatric wisdom that the disorder could be traced to emotional traumas like overly strict toilet training. Dr. Rapoport showed that obsessive-compulsive disorder is not a neurosis, but a neurological disease. She demonstrated that it ran in families, suggesting a biological origin, and she oversaw double-blind drug trials that in 1989 led the Food and Drug Administration to approve the first medication to treat the disorder, Anafranil. “People would stop her on the street and say how much she helped them,” Dr. Francisco X. Castellanos, a child psychiatrist who worked under her, said in an interview. “Her book alerted people that they could get help, that it was not their fault. It was a gigantic leap in science and also in public health.” © 2026 The New York Times Company

Keyword: OCD - Obsessive Compulsive Disorder
Link ID: 30183 - Posted: 04.01.2026

Lynne Peeples In 2021, dermatologist David Ozog was on holiday with his family in the Bahamas, when his 18-year-old son had a massive stroke. The teenager was airlifted to Florida, and then to Chicago for surgery. As his son was lying partially paralysed in a hospital bed, Ozog got a call from a colleague who had an unconventional suggestion. The colleague, a dermatologist at Harvard Medical School in Boston, Massachusetts, told Ozog about research he was conducting with the US Department of Defense. Early results hinted that red and near-infrared light applied to the head might protect neural tissue after brain injury. He urged Ozog to consider trying it on his son. Ozog stayed up until 4 a.m. that night reading scientific papers and, ultimately, ordering several panels made of red and near-infrared light-emitting diodes (LEDs). “I started sneaking them into the hospital,” says Ozog, who works at Henry Ford Health in Grand Rapids, Michigan. Today, his son is walking and back in university. Ozog cannot prove that light therapy made a difference, but he thinks that it helped. He has since become a convert to an idea that, at the time, was considered fringe. “I thought the same thing,” he says, “How could shining this thing on you possibly have any biologic effect?” But what was at the margins of medicine just a few years ago is now edging towards the mainstream. Red-light devices are increasingly appearing in dermatology offices, wellness centres, locker rooms and homes. According to some projections, the global market will surpass US$1 billion by 2030, propelled by a surge of companies promising benefits for everything from ageing skin to attention deficit hyperactivity disorder (ADHD) — claims echoed widely across social media. Experts warn that there is considerable hype about red-light therapy. But a growing body of legitimate science has been exploring the benefits for several conditions. Clinical studies have reported improvements in peripheral neuropathy1, retinal degeneration2 and certain neurological disorders3. For some indications, expert groups now recommend red-light regimens1. Researchers are also uncovering how red and near-infrared light might exert these effects. Mitochondria — the power plants of the cell — are emerging as a central piece of the puzzle. © 2026 Springer Nature Limited

Keyword: Stroke; Parkinsons
Link ID: 30182 - Posted: 03.28.2026

By Angie Voyles Askham The idea that some neural representations can “drift,” or change over time, even in the seeming absence of learning, is broadly accepted. But characterizing the phenomenon across the brain has proved challenging. “The interesting part is what exactly seems to be stable and what exactly seems to be drifting. That’s not an easy question,” says Tobias Rose, a group leader at the University of Bonn Medical Center, who presented findings on drift in the mouse primary visual cortex earlier this month at the Computational and Systems Neuroscience (COSYNE) annual meeting. Other new research adds nuance to the discussion: Neurons that code for head direction in the mouse post-subiculum show little drift, retaining their tuning for multiple weeks, according to a study published last month in Nature. And they differ from hippocampal place cells, which are also part of the spatial navigation system but have highly variable responses, as reported in previous research. The new findings raise questions about how stable and flexible representations interact in the brain, given that signals from the post-subiculum ultimately feed into the hippocampus, says Rose, who was not involved in the work. “It’s a rather important study,” he says. The relative stability of head direction cell tuning does not invalidate previous reports of drift elsewhere in the brain, says Adrien Peyrache, associate professor at the Montreal Neurological Institute, who led the head direction study. Instead, it may be that these invariant responses act as a “rigid backbone” onto which more flexible sensory and cognitive responses can be mapped, he says. “I find it reassuring.” Still, the low drift reported in the new work may be partially due to the study’s methods, which eliminated cells that lost their response from one day to the next, says Timothy O’Leary, professor of information engineering and neuroscience at the University of Cambridge, who was not involved in the work. © 2026 Simons Foundation

Keyword: Learning & Memory
Link ID: 30181 - Posted: 03.28.2026

Gemma Conroy Scientists have created the first atlas of specific key patterns of brain ‘chatter’ and determined how these patterns change over the entire human lifespan1. The comprehensive guide draws on brain scans from almost 3,600 people, ranging from infants to centenarians. It maps a property called functional connectivity, which describes the level of coordination between separate brain regions. The data suggest that in young adults, particular patterns of this connectivity are linked to cognitive performance. Such a guide could be useful for understanding when developmental issues and neurodegenerative conditions emerge, says Jakob Seidlitz, a neuroscientist at the University of Pennsylvania in Philadelphia, who was not involved in the research. “This is an important contribution to the field,” he adds. The findings were published today in Nature. The brain is a noisy place. Sometimes two brain regions that are far apart are active at the same time, suggesting that they work together to support the same function. Such regions are said to be functionally connected, even though they do not necessarily sit close to each other in the brain. To understand how this functional connectivity is organized, brain areas are plotted along a scale, or axis, on the basis of their connectivity patterns with the rest of the brain, says study co-author Patrick Taylor, a computer scientist at the University of North Carolina at Chapel Hill who focuses on neuroscience. There are three main functional axes. The sensory-to-association axis, for example, allows researchers to describe brain regions that lie along a continuum from those that focus mainly on processing sensory information to those that are engaged in sophisticated processes such as integrating sensory information into complex thought. The brain regions at each point along the axis have similar patterns of connectivity. © 2026 Springer Nature Limited

Keyword: Development of the Brain
Link ID: 30180 - Posted: 03.28.2026

By Michael S. Rosenwald Robert Trivers, a visionary, eccentric and volatile evolutionary biologist who explored the genetic reasons humans cooperate, compete and deceive each other, drawing comparisons to Charles Darwin in a career filled with intellectual highs and behavioral lows, died on March 12, in Mount Vernon, N.Y. He was 83. His death, at his daughter Natasha Trivers Howard’s home, was confirmed by his family. No cause was given. Professor Trivers was a rebellious figure in academia who joined the Black Panthers, clashed with colleagues and spoke in support of the convicted sex offender Jeffrey Epstein, from whom he accepted research money. He was often stoned and nearly always armed with a knife for self-defense. “Robert Trivers was unlike any other academic I have known,” David A. Haig, an evolutionary biologist at Harvard, wrote in a remembrance of Professor Trivers for the journal Evolution and Human Behavior. “In another life, he might have been a hoodlum.” Raised by a diplomat and a poet, and educated at Phillips Academy in Andover, Mass., and Harvard University, Professor Trivers thrived on challenging scientific orthodoxies, calling the field of psychology a “set of competing guesses.” (He also scorned physics, noting that its utility was “connected primarily to warfare.”) In the early 1970s, as a graduate student at Harvard and later as an untenured professor there, he published a series of papers applying Darwin’s theory of natural selection to social behavior, arguing that science had failed to connect evolution to an understanding of everyday life. © 2026 The New York Times Company

Keyword: Evolution
Link ID: 30179 - Posted: 03.28.2026

By Andrew Jacobs Over the past two years, Australia, a country long known for its strict drug laws, has been allowing psychiatrists to treat post-traumatic stress disorder with MDMA, the chemical compound better known as Ecstasy or molly. The early results have been striking, researchers say, with more than half of patients who received MDMA along with psychotherapy reporting significant relief from PTSD. Just as notably, Australian drug regulators have not recorded any serious adverse events among the nearly 200 patients who have been through the program, which includes up to three dosing sessions with MDMA, a synthetic stimulant that promotes empathy, emotional connection and feelings of euphoria. That data point is especially relevant given the contentious debate in the United States over the safety of MDMA — one that in 2024 helped sink the prospects for MDMA therapy at the Food and Drug Administration. “Compared to conventional treatments, the outcomes we’re seeing to date with MDMA-assisted therapy have been extraordinary,” said Dr. Ranil Gunewardene, a psychiatrist in Sydney who has treated more than 40 patients since the Australian regulators created a legal pathway for the drug. But Australia’s experiment with psychedelic medicine also highlights the limitations and constraints that the nascent field is likely to face as it gains wider attention from regulators and practitioners. Because Australia is the first country to legalize and regulate MDMA therapy, researchers have been especially eager for real-world data about a drug that has been pejoratively associated with rave culture. © 2026 The New York Times Company

Keyword: Stress; Drug Abuse
Link ID: 30177 - Posted: 03.25.2026

By Jennie Erin Smith Can a “friendly” rivalry between two artificial intelligence (AI) agents help reveal how the brain supports consciousness? That’s the suggestion coma researcher Martin Monti and his colleagues at the University of California, Los Angeles make in a paper published today in Nature Neuroscience. One of their two AI models generated realistic imitations of electrical patterns seen in conscious and unconscious brain states, from wakefulness to deep comas. Its counterpart had to identify these states. The results largely support established ideas about how the brain behaves during comas, vegetative states, and other disorders of consciousness. But they also suggest roles for a brain structure and a pattern of cell signaling not previously known to be involved in such disorders—predictions the scientists were able to test. Monti spoke with Science about how the paper’s two models, which he calls the “black box” and the “glass brain,” could reveal new ways to restore consciousness after brain injury. This interview has been edited for clarity and lengt Q: You built two AI models, with one designed to interrogate the other. Can you explain how they talk to each other? A: So here’s the game: We have two friends. One—let’s call it the black box—knows how to tell consciousness from unconsciousness. It’s been trained on 680,000 snippets of EEG [electroencephalography] data from animals and people in different states of consciousness. The other—think of it as a glass brain—is a real, biologically plausible simulation of the human brain. We tell it, “Your job is to move all of your knobs, every single parameter you’ve got, to trick the other guy—the black box—to think that you’re creating a real EEG of a conscious or unconscious state.” Now, we ask the glass brain, “Which brain parameters made the box think the EEG was unconscious?” © 2026 American Association for the Advancement of Science.

Keyword: Consciousness; Robotics
Link ID: 30176 - Posted: 03.25.2026

By Sarah Scoles When George W. Maschke applied to work for the FBI in 1994, he had already held a security clearance for over 11 years. The government had deemed him trustworthy through his career in the Army. But soon, a machine and a man would not come to the same conclusion. His application to be a special agent had passed initial muster. And so, in the spring of 1995, according to his account, he found himself sitting across from an FBI polygraph examiner, answering questions about his life and loyalties. He told the truth, he said in an interview with Undark. But in a blog post on his website, he recalled the examiner told him that the polygraph machine — which measured some of Maschke’s physiological responses — indicated that he was being deceptive about keeping classified information secret, and about his contacts with foreign intelligence agencies. After a failed polygraph exam in which he says he told the truth, George Maschke eventually co-founded the advocacy website AntiPolygraph.org. “My entire career prospects were basically shattered,” said Maschke. “How could I have told the truth and failed the polygraph?” He wanted an answer. And so soon after his failed exam, he said he went to the research library to try to learn more about what had transpired between his body, that machine, and the measuring man. Further spurred by another negative polygraph experience, the resulting deep dive on polygraphs and examination methods eventually led him to co-found the advocacy website AntiPolygraph.org. “When I had my polygraph experience, I had no one to talk to,” said Maschke, who went on to work as a legal translator in the Netherlands. He hoped his public-facing website meant others wouldn’t have that experience.

Keyword: Stress
Link ID: 30175 - Posted: 03.25.2026

By Holly Barker Astrocytes—but not neurons—in the amygdala encode anxiety-like states in mice, according to a paper published today in Neuron. The findings suggest that the cells—which are altered in people with some neuropsychiatric conditions, including autism—contribute to mental health difficulties documented in such groups. “In a very sophisticated way, the [study] shows that astrocytes are these core computational cells for highly complicated behaviors,” says Michael Wheeler, assistant professor of neurology at Harvard University, who did not contribute to the new work. “Astrocytes are understanding and signaling computations in these circuits.” Violent movies and other stressful stimuli activate the amygdala, human imaging studies have shown. And in mice, neurons in the basolateral amygdala are active when the animals are placed in exposed environments, which they find aversive, previous research has found. But that neuronal activity appears to mark shifts between defensive and exploratory behaviors rather than tracking anxiety-related ones, according to a later study. The new findings suggest that astrocytes not only help neurons to regulate anxiety—as previous studies have shown—but “instruct local neurons from the top down,” says study investigator Ciaran Murphy-Royal, associate professor of neuroscience at the University of Montreal. The cells’ activity appears to function as a “safety signal,” that relays danger to other brain regions, he says. Murphy-Royal and his colleagues used calcium imaging to measure astrocytic activity in the mouse basolateral amygdala. Calcium release tracked with freezing, hesitancy and other behaviors reminiscent of anxiety as mice investigated various environments, the team found. In the elevated plus maze, for example, astrocyte activity rose when the rodents explored an open arm of the maze and surged whenever mice peeked over the edge of the suspended setup. © 2026 Simons Foundation

Keyword: Emotions; Glia
Link ID: 30174 - Posted: 03.25.2026