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By Ajdina Halilovic When Todd Sacktor (opens a new tab) was about to turn 3, his 4-year-old sister died of leukemia. “An empty bedroom next to mine. A swing set with two seats instead of one,” he said, recalling the lingering traces of her presence in the house. “There was this missing person — never spoken of — for which I had only one memory.” That memory, faint but enduring, was set in the downstairs den of their home. A young Sacktor asked his sister to read him a book, and she brushed him off: “Go ask your mother.” Sacktor glumly trudged up the stairs to the kitchen. It’s remarkable that, more than 60 years later, Sacktor remembers this fleeting childhood moment at all. The astonishing nature of memory is that every recollection is a physical trace, imprinted into brain tissue by the molecular machinery of neurons. How the essence of a lived moment is encoded and later retrieved remains one of the central unanswered questions in neuroscience. Sacktor became a neuroscientist in pursuit of an answer. At the State University of New York Downstate in Brooklyn, he studies the molecules involved in maintaining the neuronal connections underlying memory. The question that has always held his attention was first articulated in 1984 (opens a new tab) by the famed biologist Francis Crick: How can memories persist for years, even decades, when the body’s molecules degrade and are replaced in a matter of days, weeks or, at most, months? In 2024, working alongside a team that included his longtime collaborator André Fenton (opens a new tab), a neuroscientist at New York University, Sacktor offered a potential explanation in a paper published in Science Advances. The researchers discovered that a persistent bond between two proteins (opens a new tab) is associated with the strengthening of synapses, which are the connections between neurons. Synaptic strengthening is thought to be fundamental to memory formation. As these proteins degrade, new ones take their place in a connected molecular swap that maintains the bond’s integrity and, therefore, the memory. © 2025 Simons Foundation
Keyword: Learning & Memory
Link ID: 29784 - Posted: 05.11.2025
By Katharine Gammon Picture this: You’re sitting down, engrossed in a meal, when an unfamiliar person walks by. There’s something about them—Hair? Smile? Vibes?—that instantly draws you in and makes you want to strike up a friendship. A new study suggests that it could be the scent they exude that attracts you to them. Not just the way their skin or hair smells, but the deodorant and shampoo they use, the foods they consume, even their laundry detergent. Our sense of smell tends to operate below the level of conscious awareness, says Jessica Gaby, a psychology researcher at Middle Tennessee State University and an author of the study, so our responses to it are often hidden from us. “But at the same time, it’s inescapable,” she says. “You can’t fake it.” Gaby and her colleagues, who were at Cornell University when the study was conducted, brought 40 women aged 18-30 together in a Cornell dining hall, a large, refurbished barn with café tables that doubles as a beer hall at night. The scent of popcorn, beer, and leftover dinner wafted over the room: The idea was to have a complex olfactory environment. The women all identified as heterosexual, so the researchers could focus on the type of attraction that might lead to friendship. In the first phase of the study, the participants received cotton T-shirts and were instructed to wear them for 12 hours straight without altering their daily routines, and to keep notes about their activities. One participant used spray paint in an art project, another had sex, another said she spilled a small amount of black beans on her shirt. In the second phase of the study, the participants were instructed to view photographs of different individual women, some of whom they would later meet. They then each sniffed the worn T-shirts, then had four-minute meetings, speed-dating style, with the other individual women, then sniffed their T-shirts again. After each step, they judged their friendship potential with the other women on a scale of 1 to 7. © 2025 NautilusNext Inc.,
Keyword: Chemical Senses (Smell & Taste); Emotions
Link ID: 29783 - Posted: 05.11.2025
By Calli McMurray At least six new brain donors who can do a functional MRI scan—that’s what it will take to complete the most comprehensive human brain atlas yet, project investigators say. The Human and Mammalian Brain Atlas (HMBA) aims to capture information about the identity and location of cells across the entire brain and tie it, for the first time, to the functional organization of the cortex. The atlas, one of several projects in the BRAIN Initiative Cell Atlas Network funded by the U.S. National Institutes of Health, stands to be “a quantum jump in the quality of the data and the resolution that we can analyze it,” says David Van Essen, professor of neuroscience at Washington University in St. Louis and an HMBA investigator. The first atlas, published by the Allen Institute in 2011, contains gene expression information across the brain projected onto an MRI reference space. “By today’s standards, that’s really low-resolution information,” but it’s still “used like crazy,” says Ed Lein, co-creator of the first atlas and one of the lead investigators of the HMBA project at the Allen Institute for Brain Science. Subsequent iterations mapped more of the human brain’s cellular and molecular landscape and at higher resolution. A “first draft” cell atlas, Lein says, published in a trove of papers in 2023, employed single-cell sequencing techniques to catalog thousands of cell types in the human brain. But as “exceptional” as these resources are, their utility is limited by a lack of functional information about the brain regions, says Avram Holmes, associate professor of psychiatry at Rutgers University, who is not involved with the project. © 2025 Simons Foundation
Keyword: Development of the Brain; Brain imaging
Link ID: 29782 - Posted: 05.11.2025
By Jake Buehler Grunts, barks, screams and pants ring through Taï National Park in Cȏte d’Ivoire. Chimpanzees there combine these different calls like linguistic Legos to relay complex meanings when communicating, researchers report May 9 in Science Advances. Chimps can combine and flexibly rearrange pairs of sounds to convey different ideas or meanings, an ability that investigators have not documented in other nonhuman animals. This system may represent a key evolutionary transition between vocal communication strategies of other animals and the syntax rules that structure human languages. “The difference between human language and how other animals communicate is really about how we combine sounds to form words, and how we combine words to form sentences,” says Cédric Girard-Buttoz, an evolutionary biologist at CNRS in Lyon, France. Chimpanzees (Pan troglodytes) were known to have a particularly complicated vocal repertoire, with about a dozen single sounds that they can combine into hundreds of sequences. But it was unclear if the apes used multiple approaches when combining sounds to make new meanings, like in human language. In 2019 and 2020, Girard-Buttoz and his colleagues recorded 53 different adult chimpanzees living in the Taï forest. In all, the team analyzed over 4,300 sounds and described 16 different “bigrams” — short sequences of two sounds, like a grunt followed by a bark, or a panted hoo followed by a scream. The team then used statistical analyses to map those bigrams to behaviors to reveal some of the bigrams’ meanings. The result? Chimpanzees don’t combine sounds in a single, consistent way. They have at least four different methods — a first seen outside of humans. © Society for Science & the Public 2000–2025
Keyword: Language; Evolution
Link ID: 29781 - Posted: 05.11.2025
By Asher Elbein True friends, most people would agree, are there for each other. Sometimes that means offering emotional support. Sometimes it means helping each other move. And if you’re a superb starling — a flamboyant, chattering songbird native to the African savanna — it means stuffing bugs down the throats of your friends’ offspring, secure in the expectation that they’ll eventually do the same for yours. Scientists have long known that social animals usually put blood relatives first. But for a study published Wednesday in the journal Nature, researchers crunched two decades of field data to show that unrelated members of a superb starling flock often help each other raise chicks, trading assistance to one another over years in a behavior that was not previously known. “We think that these reciprocal helping relationships are a way to build ties,” said Dustin Rubenstein, a professor of ecology at Columbia University and an author of the paper. Superb starlings are distinctive among animals that breed cooperatively, said Alexis Earl, a biologist at Cornell University and an author of the paper. Their flocks mix family groups with immigrants from other groups. New parents rely on up to 16 helpers, which bring chicks extra food and help run off predators. Dr. Rubenstein’s lab has maintained a 20-year field study of the species that included 40 breeding seasons. It has recorded thousands of interactions between hundreds of the chattering birds and collected DNA to examine their genetic relationships. When Dr. Earl, then a graduate student in the lab, began crunching the data, she and her colleagues weren’t shocked to see that birds largely helped relatives, the way an aunt or uncle may swoop in to babysit and give parents a break. © 2025 The New York Times Company
Keyword: Evolution; Emotions
Link ID: 29780 - Posted: 05.10.2025
Bobbi-Jean MacKinnon A new scientific study has found no evidence of a mystery brain disease in New Brunswick, says a report published Wednesday in the Journal of the American Medical Association, known as JAMA. Instead, an independent reassessment of 25 of 222 patients diagnosed by Moncton neurologist Alier Marrero as having a "neurological syndrome of unknown cause" concluded that all of the cases were attributable to well-known conditions. These include common neurodegenerative diseases, such as Alzheimer's and Parkinson's, functional neurological disorder, traumatic brain injury, and metastatic cancer, says the report. Despite the small sample size, "when we did the statistics … the chances of any of those other individuals having a mystery disease was less than one in a million," said Dr. Anthony Lang, a senior neurologist and neuroscientist in Toronto, and one of the 13 co-authors. The researchers, affiliated with the University of Toronto, New Brunswick's Horizon Health Network and other Canadian institutions, do not believe exposure to something in the environment, such as the herbicide glyphosate or heavy metals, made the patients ill either, said Lang, director of the Edmund J Safra Program in Parkinson's Disease at the University Health Network. "The neurological problems varied a great deal. Some had neurodegenerative diseases, but others had other neurological problems and therefore a single environmental toxin … could never have explained this broad variety of neurological abnormalities." Lang, who got involved in the study because he started hearing about a mystery disease but wasn't seeing any publications in medical literature, is not surprised by the results. ©2025 CBC/Radio-Canada.
Keyword: Movement Disorders; Alzheimers
Link ID: 29779 - Posted: 05.10.2025
Freda Kreier Some people can function well on little sleep.Credit: Oleg Breslavtsev/Getty Most people need around eight hours of sleep each night to function, but a rare genetic condition allows some to thrive on as little as three hours. In a study published today in the Proceedings of the National Academy of Sciences1, scientists identified a genetic mutation that probably contributes to some people’s limited sleep needs. Understanding genetic changes in naturally short sleepers — people who sleep for three to six hours every night without negative effects — could help to develop treatments for sleep disorders, says co-author Ying-Hui Fu, a neuroscientist and geneticist at the University of California, San Francisco. “Our bodies continue to work when we go to bed”, detoxifying themselves and repairing damage, she says. “These people, all these functions our bodies are doing while we are sleeping, they can just perform at a higher level than we can.” In the 2000s, Fu and her colleagues were approached by people who slept six hours or less each night. After analysing the genomes of a mother and daughter, the team identified a rare mutation in a gene that helps to regulate humans’ circadian rhythm, the internal clock responsible for our sleep–wake cycle. The researchers suggested that this variation contributed to the duo’s short sleep needs. That discovery prompted others with similar sleeping habits to contact the laboratory for DNA testing. The team now knows several hundred naturally short sleepers. Fu and her colleagues have so far identified five mutations in four genes that can contribute to the trait — although different families tend to have different mutations. Short sleeper In the latest study, the researchers searched for new mutations in the DNA of a naturally short sleeper. They found one in SIK3, a gene encoding an enzyme that, among other things, is active in the space between neurons. Researchers in Japan had previously found another mutation in Sik3 that caused mice to be unusually sleepy2. © 2025 Springer Nature Limited
Keyword: Sleep; Genes & Behavior
Link ID: 29778 - Posted: 05.07.2025
By Giorgia Guglielmi Newly formed memories change over the course of a night’s sleep, a new study in rats suggests. The results reveal that memory processing and consolidation is more complex and prolonged than previously understood, says study investigator Jozsef Csicsvari, professor of systems neuroscience at the Institute of Science and Technology Austria. Sleep has long been known to help consolidate memories, though most studies have tracked only a few hours of this process. The new work monitored memory-related brain activity patterns across almost an entire day—representing a significant step forward, says Lisa Genzel, associate professor of neuroscience at Radboud University, who wasn’t involved in the research. That’s “a heroic effort,” she says. Csicsvari and his team implanted wireless electrodes into the hippocampus of three rats and recorded neuronal activity as the animals learned to navigate a maze in search of hidden pieces of food, rested or slept for 16 to 20 hours after, and then revisited the same food locations the following day. The neurons that fired during learning became active again throughout the rest period, especially during sleep, the team found. This reactivation is a key part of memory consolidation, and it doesn’t just happen immediately after learning; instead, it continues for hours, the study shows. And while the animals slept, their brain activity patterns gradually shifted to resemble the post-sleep recall patterns—a change known as “representational drift” that likely helps the brain weave new information into what it already knows, Csicsvari says. Some neuron groups may be more involved than others in updating memories, the work showed. Some cell types remained stable, whereas others changed their activity. For example, hippocampal neurons called CA1 pyramidal cells showed distinct firing patterns during memory reactivation. And interneurons, too, appeared to play a supporting role, mirroring the changes in pyramidal cells. The team published their findings in Neuron in March. © 2025 Simons Foundation
Keyword: Sleep; Learning & Memory
Link ID: 29777 - Posted: 05.07.2025
By Rachel Lehmann-Haupt On a brisk January evening this year, I was speeding down I–295 in northeast Florida, under a full moon, to visit my dad’s brain. As I drove past shadowy cypress swamps, sinewy river estuaries, and gaudy-hued billboards of condominiums with waterslides and red umbrellas boasting, “Best place to live in Florida,” I was aware of the strangeness of my visit. Most people pay respects to their loved ones at memorials and grave sites, but I was intensely driven to check in on the last remaining physical part of my dad, immortalized in what seemed like the world’s most macabre library. Michael DeTure, a professor of neuroscience, stepped out of a golf cart to meet me. “Welcome to the bunker. Just 8,000 of your quietest friends in here,” he said in a melodic southern drawl, grinning in a way that told me he’s made this joke before. The bunker is an indiscriminate warehouse, part of the Mayo Clinic’s Jacksonville, Florida campus that houses its brain bank. DeTure opened the warehouse door, and I was met with a blast of cold air. In the back of the warehouse sat rows of buzzing white freezers. DeTure pointed to the freezer where my dad’s brain sat in a drawer in a plastic bag with his name written on it in black Sharpie pen. I welled up with tears and a feeling of intense fear. The room suddenly felt too cold, too sterile, too bright, and my head started to spin. I wanted to run away from this place. And then my brain escaped for me. I saw my dad on a beach on Cape Cod in 1977. He was in a bathing suit, shirtless, lying on a towel. I was 7 years old and snuggled up to him to protect myself from the wind. He was reading aloud to my mom and me from Evelyn Waugh’s novel, A Handful of Dust, whose title is from T.S. Eliot’s poem, “The Wasteland”: “I will show you fear in a handful of dust.” He was reading the part about Tony Last, an English gentleman, being imprisoned by an eccentric recluse who forces him to read Dickens endlessly. © 2025 NautilusNext Inc.,
Keyword: Language; Learning & Memory
Link ID: 29776 - Posted: 05.07.2025
By Lizzie Wade As John Rick excavated one of the many underground chambers at the ancient Peruvian site of Chavín de Huántar in 2017 his trowel hit something intriguing, and exceedingly delicate. It was a cigarette-size tube made of animal bone and packed full of sediment. The following year, his team found almost two dozen more. Rick, an archaeologist at Stanford University, suspected these bone tubes were pieces of ancient drug paraphernalia. Now, a chemical analysis of plant material preserved inside the bone tubes confirms ancient people used them to inhale snuffs made of tobacco and a hallucinogenic plant known as vilca. Rick and colleagues say the rituals involving these drugs may have helped the people of Chavín consolidate their power and influence some 2500 years ago, a time when complex social and political hierarchies were first taking shape in Peru. Although researchers have long suspected rituals at Chavín involved hallucinogenic drugs, “What’s exciting about this paper is that, for first time, we have actual evidence,” says José Capriles, an archaeologist at Pennsylvania State University who wasn’t involved in the research but has studied psychoactive drugs used by ancient people. Chavín de Huántar, which was occupied in the first millennium B.C.E., is renowned for its intricate stone carvings, often depicting animal-human hybrids or transformations of human into beast, and an extensive network of underground chambers. It also had a broad cultural reach. The site in Peru’s north-central highlands abounds with seashells and obsidian, neither found locally, and Chavín-style art shows up in many places throughout the Andes and on the Peruvian coast. “Chavín was part of the first big moment in Andean prehistory when people, ideas, and goods were circulating quite extensively,” says Dan Contreras, an archaeologist at the University of Florida and a co-author of the new paper.
Keyword: Drug Abuse
Link ID: 29775 - Posted: 05.07.2025
By Susan Milius Here’s a great case of real life turning out to be stranger than fiction. From baby’s first storybook to sly adult graphic novels, the story we’re told is the same: Male frogs croak with the bottom of their mouths ballooning out in one fat, rounded bubble. Yet “that’s actually only half the species of frogs,” says herpetologist Agustín Elías-Costa of the Bernardino Rivadavia Natural Science Museum in Buenos Aires. The diversity of body parts for ribbitting is astounding. Some males serenade with a pair of separate puff-out disks like padded headphones that slipped down the frog’s neck, throbbing in brilliant blue. Some have sacs that look like balloon Mickey Mouse ears in khaki. Others ribbit with a single upright like a fat horn stub on some inflatable swimming pool toy rhino. All together, 20 basic forms for vocal sacs have evolved among frogs and toads, Elías-Costa and herpetologist Julián Faivovich report in March in the Bulletin of the American Museum of Natural History. Still, about 18 percent of the 4,358 species examined didn’t have vocal sacs at all. The team studied 777 specimens over 10 years of visiting museums around the world, including the Smithsonian’s National Museum of Natural History in Washington, D.C. “Libraries of nature,” Faivovich calls them. Just drawing a picture of something doesn’t authenticate details the way a preserved specimen does. These collections for biodiversity studies are “what makes them a science,” he says. The survey showed that vocal sacs disappeared between 146 and 196 times across the very twiggy evolutionary branchings of the frog and toad family tree. That’s “an astounding number considering their biological importance,” Elías-Costa says. Even without sacs, the animals still emit sounds because, like human speech, frog and toad ribbits originate from the larynx. Vocal sacs amplify the sound and could convey nuances of male quality and sexiness, but can also tip off eavesdropping predators. Females in a few species vocalize too, but it’s mostly a male endeavor. © Society for Science & the Public 2000–2025.
Keyword: Sexual Behavior; Hearing
Link ID: 29774 - Posted: 05.07.2025
By Carl Zimmer Consciousness may be a mystery, but that doesn’t mean that neuroscientists don’t have any explanations for it. Far from it. “In the field of consciousness, there are already so many theories that we don’t need more theories,” said Oscar Ferrante, a neuroscientist at the University of Birmingham. If you’re looking for a theory to explain how our brains give rise to subjective, inner experiences, you can check out Adaptive Resonance Theory. Or consider Dynamic Core Theory. Don’t forget First Order Representational Theory, not to mention semantic pointer competition theory. The list goes on: A 2021 survey identified 29 different theories of consciousness. Dr. Ferrante belongs to a group of scientists who want to lower that number, perhaps even down to just one. But they face a steep challenge, thanks to how scientists often study consciousness: Devise a theory, run experiments to build evidence for it, and argue that it’s better than the others. “We are not incentivized to kill our own ideas,” said Lucia Melloni, a neuroscientist at the Max Planck Institute for Empirical Aesthetics in Frankfurt, Germany. Seven years ago, Dr. Melloni and 41 other scientists embarked on a major study on consciousness that she hoped would break this pattern. Their plan was to bring together two rival groups to design an experiment to see how well both theories did at predicting what happens in our brains during a conscious experience. The team, called the Cogitate Consortium, published its results on Wednesday in the journal Nature. But along the way, the study became subject to the same sharp-elbowed conflicts they had hoped to avoid. Dr. Melloni and a group of like-minded scientists began drawing up plans for their study in 2018. They wanted to try an approach known as adversarial collaboration, in which scientists with opposing theories join forces with neutral researchers. The team chose two theories to test. © 2025 The New York Times Company
Keyword: Consciousness
Link ID: 29773 - Posted: 05.03.2025
By Anil Seth On stage in New York a couple years ago, noted neuroscientist Christof Koch handed a very nice bottle of Madeira wine to philosopher David Chalmers. Chalmers had won a quarter-century-long bet about consciousness—or at least our understanding of it. Nautilus Members enjoy an ad-free experience. Log in or Join now . The philosopher had challenged the neuroscientist in 1998—with a crate of fine wine on the line—that in 25 years, science would still not have located the seat of consciousness in the brain. The philosopher was right. But not without an extraordinary—and revealing—effort on the part of consciousness researchers and theorists. Backing up that concession were the results of a long and thorough “adversarial collaboration” that compared two leading theories about consciousness, testing each with rigorous experimental data. Now we finally learn more about the details of this work in a new paper in the journal Nature. Nicknamed COGITATE, the collaboration pitted “global neuronal workspace theory” (GNWT)—an idea advocated by cognitive neuroscientist Stanislas Dehaene, which associates consciousness with the broadcast of information throughout large swathes of the brain—against “integrated information theory” (IIT)—the idea from neuroscientist Giulio Tononi, which identifies consciousness with the intrinsic cause-and-effect power of brain networks. The adversarial collaboration involved the architects of both theories sitting down together, along with other researchers who would lead and execute the project (hats off to them), to decide on experiments that could potentially distinguish between the theories—ideally supporting one and challenging the other. Deciding on the theory-based predictions, and on experiments good enough to test them, was never going to be easy. In consciousness research, it is especially hard since—as philosopher Tim Bayne and I noted—theories often make different assumptions, and attempt to explain different things even if, on the face of it, they are all theories of “consciousness.” © 2025 NautilusNext Inc.,
Keyword: Consciousness
Link ID: 29772 - Posted: 05.03.2025
By Allison Parshall ] Where in the brain does consciousness originate? Theories abound, but neuroscientists still haven’t coalesced around one explanation, largely because it’s such a hard question to probe with the scientific method. Unlike other phenomena studied by science, consciousness cannot be observed externally. “I observe your behavior. I observe your brain, if I do an intracranial EEG [electroencephalography] study. But I don’t ever observe your experience,” says Robert Chis-Ciure, a postdoctoral researcher studying consciousness at the University of Sussex in England. Scientists have landed on two leading theories to explain how consciousness emerges: integrated information theory, or IIT, and global neuronal workspace theory, or GNWT. These frameworks couldn’t be more different—they rest on different assumptions, draw from different fields of science and may even define consciousness in different ways, explains Anil K. Seth, a consciousness researcher at the University of Sussex. To compare them directly, researchers organized a group of 12 laboratories called the Cogitate Consortium to test the theories’ predictions against each other in a large brain-imaging study. The result, published in full on Wednesday in Nature, was effectively a draw and raised far more questions than it answered. The preliminary findings were posted to the preprint server bioRxiv in 2023. And only a few months later, a group of scholars publicly called IIT “pseudoscience” and attempted to excise it from the field. As the dust settles, leading consciousness researchers say that the Cogitate results point to a way forward for understanding how consciousness arises—no matter what theory eventually comes out on top. “We all are very good at constructing castles in the sky” with abstract ideas, says Chis-Ciure, who was not involved in the new study. “But with data, you make those more grounded.” © 2025 SCIENTIFIC AMERICAN,
Keyword: Consciousness
Link ID: 29771 - Posted: 05.03.2025
By Yasemin Saplakoglu In 1943, a pair of neuroscientists were trying to describe how the human nervous system works when they accidentally laid the foundation for artificial intelligence. In their mathematical framework (opens a new tab) for how systems of cells can encode and process information, Warren McCulloch and Walter Pitts argued that each brain cell, or neuron, could be thought of as a logic device: It either turns on or it doesn’t. A network of such “all-or-none” neurons, they wrote, can perform simple calculations through true or false statements. “They were actually, in a sense, describing the very first artificial neural network,” said Tomaso Poggio (opens a new tab) of the Massachusetts Institute of Technology, who is one of the founders of computational neuroscience. McCulloch and Pitts’ framework laid the groundwork for many of the neural networks that underlie the most powerful AI systems. These algorithms, built to recognize patterns in data, have become so competent at complex tasks that their products can seem eerily human. ChatGPT’s text is so conversational and personal that some people are falling in love (opens a new tab). Image generators can create pictures so realistic that it can be hard to tell when they’re fake. And deep learning algorithms are solving scientific problems that have stumped humans for decades. These systems’ abilities are part of the reason the AI vocabulary is so rich in language from human thought, such as intelligence, learning and hallucination. But there is a problem: The initial McCulloch and Pitts framework is “complete rubbish,” said the science historian Matthew Cobb (opens a new tab) of the University of Manchester, who wrote the book The Idea of the Brain: The Past and Future of Neuroscience (opens a new tab). “Nervous systems aren’t wired up like that at all.” A promotional card for Quanta's AI series, which reads Science Promise and the Peril of AI, Explore the Series" When you poke at even the most general comparison between biological and artificial intelligence — that both learn by processing information across layers of networked nodes — their similarities quickly crumble. © 2025 Simons Foundation
Keyword: Consciousness; Robotics
Link ID: 29770 - Posted: 05.03.2025
By Laura Dattaro In 2012, neuroscientists Sebastian Seung and J. Anthony Movshon squared off at a Columbia University event over the usefulness of connectomes—maps of every connection between every cell in the brain of a living organism. Such a map, Seung argued, could crack open the brain’s computations and provide insight into processes such as sensory perception and memory. But Movshon, professor of neural science and psychology at New York University, countered that the relationship between structure and function was not so straightforward—that even if you knew how all of a brain’s neurons connect to one another, you still wouldn’t understand how the organ turns electrical signals into cognition and behavior. The debate in the field continues, even though Seung and his colleagues in the FlyWire Consortium completed the first connectome of a female Drosophila melanogaster in 2023, and even though a slew of new computational models built from that and other connectomes hint that structure does, in fact, reveal something about function. “This is just the beginning, and that’s what’s exciting,” says Seung, professor of neuroscience at the Princeton Neuroscience Institute. “These papers are kicking off a beginning to an entirely new field, which is connectome-based brain simulation.” A simulated fruit fly optic lobe, detailed in a September 2024 Nature paper, for example, accurately predicts which neurons in living fruit flies respond to different visual stimuli. “All the work that’s been done in the past year or two feels like the beginning of something new,” says John Tuthill, associate professor of neuroscience at the University of Washington. Tuthill was not involved in the optic lobe study but used a similar approach to identify a circuit that seems to control walking in flies. Most published models so far have made predictions about simple functions that were already understood from recordings of neural activity, Tuthill adds. But “you can see how this will build up to something that is eventually very insightful.” © 2025 Simons Foundation
Keyword: Brain imaging; Development of the Brain
Link ID: 29769 - Posted: 05.03.2025
Logan S. James It is late at night, and we are silently watching a bat in a roost through a night-vision camera. From a nearby speaker comes a long, rattling trill. The bat briefly perks up and wiggles its ears as it listens to the sound before dropping its head back down, uninterested. Next from the speaker comes a higher-pitched “whine” followed by a “chuck.” The bat vigorously shakes its ears and then spreads its wings as it launches from the roost and dives down to attack the speaker. Bats show tremendous variation in the foods they eat to survive. Some species specialize on fruits, others on insects, others on flower nectar. There are even species that catch fish with their feet. At the Smithsonian Tropical Research Institute in Panama, we’ve been studying one species, the fringe-lipped bat (Trachops cirrhosus), for decades. This bat is a carnivore that specializes in feeding on frogs. Male frogs from many species call to attract female frogs. Frog-eating bats eavesdrop on those calls to find their next meal. But how do the bats come to associate sounds and prey? We were interested in understanding how predators that eavesdrop on their prey acquire the ability to discriminate between tasty and dangerous meals. We combined our expertise on animal behavior, bat cognition and frog communication to investigate. © 2010–2025, The Conversation US, Inc.
Keyword: Hearing; Development of the Brain
Link ID: 29768 - Posted: 05.03.2025
Andrew Gregory Health editor Scientists have used living human brain tissue to mimic the early stages of Alzheimer’s disease, the most common form of dementia, in a breakthrough that will accelerate the hunt for a cure. In a world first, a British team successfully exposed healthy brain tissue from living NHS patients to a toxic form of a protein linked to Alzheimer’s – taken from patients who died from the disease – to show how it damages connections between brain cells in real time. The groundbreaking move offered a rare and powerful opportunity to see dementia developing in human brain cells. Experts said the new way of studying the disease could make it easier to test new drugs and boost the chances of finding ones that work. Dementia presents a big threat to health and social care systems across the world. The number of people affected is forecast to triple to nearly 153 million by 2050, which underlines why finding new ways to study the disease and speed up the search for treatments is a health priority. In the study, scientists and neurosurgeons in Edinburgh teamed up to show for the first time how a toxic form of a protein linked to Alzheimer’s, amyloid beta, can stick to and destroy vital connections between brain cells. Tiny fragments of healthy brain tissue were collected from cancer patients while they were undergoing routine surgery to remove tumours at the Royal Infirmary of Edinburgh. Scientists dressed in scrubs were stationed in operating theatres alongside surgical teams, ready to receive the healthy brain tissue, which would otherwise have been discarded. Once the pieces of brain were retrieved, scientists put them in glass bottles filled with oxygenated artificial spinal fluid before jumping into taxis to transport the samples to their lab a few minutes away. © 2025 Guardian News & Media Limited
Keyword: Alzheimers
Link ID: 29767 - Posted: 04.30.2025
RJ Mackenzie Neuroscientists have identified a brain signal in mice that kick-starts the process of overwriting fearful memories once danger is passed — a process known as fear extinction. The research is at an early stage, but could aid the development of drugs to treat conditions, such as post-traumatic stress disorder (PTSD), that are linked to distressing past experiences. In a study published on 28 April in the Proceedings of the National Academy of Sciences1, the researchers focused on two populations of neurons in a part of the brain called the basolateral amygdala (BLA). These two types of neuron have contrasting effects: one stimulates and the other suppresses fear responses, says co-author Michele Pignatelli, a neuroscientist at Massachusetts Institute of Technology in Cambridge. Until now, scientists didn’t know what activated these neurons during fear extinction, although previous research implicated the neurotransmitter dopamine, released by a specific group of neurons in another part of the brain called the ventral tegmental area (VTA). To investigate this possibility, the authors used fluorescent tracers injected into the brains of mice to show that the VTA sends dopamine signals to the BLA, and that both pro- and anti-fear neurons in the BLA can respond to these signals. They then studied the effects of these circuits on behaviour, using mice that had been genetically modified so that dopamine activity in their brains produced fluorescent light, which allowed the researchers to record the activity of the VTA–BLA connections using fibre optics. They first placed these mice into chambers that delivered mild but unpleasant electrical shocks to their feet, which made them freeze in fear. The next day, they put the mice back in the chambers but did not give them any shocks. Although initially fearful, the mice began to relax after about 15 minutes, and the researchers saw a dopamine current surge through their ‘anti-fear’ BLA neurons. © 2025 Springer Nature Limited
Keyword: Emotions; Stress
Link ID: 29766 - Posted: 04.30.2025
Hannah Thomasy, PhD In recent decades, scientists have demonstrated that prosocial behaviors are not unique to humans, or even to primates. Rats, in particular, have proved surprisingly sensitive to the distress of conspecifics, and will often come to the aid of a fellow rat in trouble. In 2011, researchers showed that when rats were provided with a clear box containing chocolate chips, they usually opened the box and consumed all the chocolate.1 But when one box contained chocolate and another contained a trapped cagemate, the rats were more likely to open both boxes and share the chocolate. But some rats didn’t play as nicely with others. In versions of the test that did not involve chocolate, only a rat and its trapped cagemate, researchers noticed that while some rats consistently freed their compatriots, others did not. In a new Journal of Neuroscience study, neuroscientists Jocelyn Breton at Northeastern University and Inbal Ben-Ami Bartal at Tel-Aviv University explored the behaviors and neural characteristics of helpers and non-helpers.2 They found that helper rats displayed greater social interactions with their cagemates, greater activity in prosocial neural networks, and greater expression of oxytocin receptors in the nucleus accumbens (NAc), providing clues about the mechanisms that govern prosocial behaviour. “We appear to live in an increasingly polarized society where there is a gap in empathy towards others,” said Bartal in a press release. “This work helps us understand prosocial, or helpful, acts better. We see others in distress all the time but tend to help only certain individuals. The similarity between human and rat brains helps us understand the way our brain mediates prosocial decisions.” To undertake these experiments, the researchers first divided the rats into pairs and allowed them to acclimatize to their cagemates for a few weeks. Then they placed the pair in the testing arena, where they allowed one rat to roam free and restrained the other in a clear box that could only be opened from the outside. While they were not trained to open the box, more than half of the rats figured out how to free their trapped companions and did so during multiple days of consecutive testing. © 1986-2025 The Scientist.
Keyword: Emotions; Evolution
Link ID: 29765 - Posted: 04.30.2025